Results 131 to 140 of about 1,150,143 (287)

A glutamine metabolic switch supports erythropoiesis

Science
Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine synthetase (GS), one of the oldest functioning genes in evolution, is activated during erythroid
Junhua Lyu, Zhimin Gu, Yuannyu Zhang, Hieu S. Vu, Christophe Lechauve, Feng Cai, Hui Cao, Julia Keith, Valentina Brancaleoni, Francesca Granata, Irene Motta, Maria Domenica Cappellini, Lily Jun-Shen Huang, Ralph J. DeBerardinis, Mitchell J. Weiss, Min Ni, Jian Xu   +16 more
openaire   +2 more sources

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Exploring the role and regulation of mitochondrial glutamine metabolism in cancer

, 2010
Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: glucose and glutamine. The oncogenes and tumor suppressors most commonly linked to cancer development stimulate glucose uptake and metabolism, rendering ...
Wise, David Reuven
core  

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

Advanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu   +13 more
wiley   +1 more source

Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies

Genes and Diseases
As a critical metabolite in the tumor microenvironment, glutamine plays a crucial role in tumor progression, and its dual effects on promoting and inhibiting tumors have garnered increasing attention in recent years.
Zizhuo Li, Jiapeng Deng, Hai Wang, Tao Liu, Yuyang Zhou, Pei Ouyang, Xuan Liang, Xian Zhang, Songtao Qi, Yaomin Li   +9 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Targeting the crosstalk between glutamine metabolism and tumor immune microenvironment for lung cancer immunotherapy

Interdisciplinary Medicine
Lung cancer remains one of the deadliest cancers globally, which may be attributed in part to a limited understanding of its development. Therefore, exploration of the fundamental processes of lung cancer and innovative therapies is imminent.
Jingyang Li, Li Xiang, Shaohui Wang, Yingrui Zhang, Shiyi Zhao, Di Zhang, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +8 more
doaj   +1 more source

The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle

, 2016
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA–glutamine cycle (GGC). In the GGC, glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools.
Schousboe, Arne, Renata Leke, Arne Schousboe, Schousboe, A., Leke, Renata,, Leke, Renata   +5 more
core   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

MedComm
Glutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various
Mudasir A. Kumar, Sana Khurshid Baba, Inamu Rashid Khan, Mohd Shahnawaz Khan, Fohad Mabood Husain, Saheem Ahmad, Mohammad Haris, Mayank Singh, Ammira S. Al‐Shabeeb Akil, Muzafar A. Macha, Ajaz A. Bhat   +10 more
doaj   +1 more source