Results 21 to 30 of about 178,237 (260)
Glutamine Metabolism Is Required for Alveolar Regeneration during Lung Injury
Biomolecules, 2022 (1) Background: Abnormal repair after alveolar epithelial injury drives the progression of idiopathic pulmonary fibrosis (IPF). The maintenance of epithelial integrity is based on the self-renewal and differentiation of alveolar type 2 (AT2) cells, which
Sisi Wang +12 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Bone marrow mesenchymal stem cells (BMSCs) play an essential role in osteoporosis. However, the molecular mechanisms and the involvement of glutamine metabolism in osteogenic BMSCs differentiation and osteoporosis remain largely unclear.
Guangsi Shen +6 more
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Journal of Orthopaedic Surgery and Research, 2022 Background Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease; cellular glutamine metabolism in fibroblast-like synoviocytes (FLSs) of RA was known to be essential for RA pathogenesis and progression.
Mei Zhang +5 more
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Increased Ammonium Toxicity in Response to Exogenous Glutamine in Metastatic Breast Cancer Cells
Metabolites, 2022 Several cancers, including breast cancers, show dependence on glutamine metabolism. The purpose of the present study was to determine the mechanistic basis and impact of differential glutamine metabolism in nonmetastatic and metastatic murine mammary ...
Violet A. Kiesel +5 more
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Neurobiology of Disease, 2021 Alzheimer's disease (AD) leads to cerebral accumulation of insoluble amyloid-β plaques causing synaptic dysfunction and neuronal death. Neurons rely on astrocyte-derived glutamine for replenishment of the amino acid neurotransmitter pools.
Jens V. Andersen +7 more
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mTORC1 Regulates Glutamine Metabolism [PDF]
Cancer Discovery, 2013 Abstract mTORC1 stimulates glutamine metabolism by inducing glutamate dehydrogenase (GDH).
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Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism.
PLoS ONE, 2017 Liver fibrosis is the excessive accumulation of extracellular matrix proteins, which is mainly caused by accumulation of activated hepatic stellate cells (HSCs).
Jiang Li +11 more
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Glutamine Metabolism in Brain Tumors [PDF]
Cancers, 2019 Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to support their uncontrolled proliferation by taking up nutrients from the microenvironment. The amino acid glutamine is a key nutrient that fuels biosynthetic processes including ATP generation, redox homeostasis, nucleotide, protein, and lipid synthesis.
Natarajan, Siva Kumar, Venneti, Sriram
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Visualization of glutamine transporter activities in living cells using genetically encoded glutamine sensors. [PDF]
PLoS ONE, 2012 Glutamine plays a central role in the metabolism of critical biological molecules such as amino acids, proteins, neurotransmitters, and glutathione. Since glutamine metabolism is regulated through multiple enzymes and transporters, the cellular glutamine
Katrin Gruenwald +5 more
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GLUTAMINE METABOLISM OF THE BEET [PDF]
Plant Physiology, 1936 Although glutamine has long been known as a plant constituent (10), the relationship of this amide to the nitrogen metabolism of the plant has seldom been subjected to direct test. The close analogy in chemical structure with asparagine and the similarity of the conditions under which the respective amides are found have led to the view, early ...
H B, Vickery, G W, Pucher, H E, Clark
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