The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
Life, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Paul Bolay +3 more
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M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation [PDF]
Nature Communications, 2023 Glutamine synthetases (GS) play central roles in cellular nitrogen assimilation. Although GS active-site formation requires the oligomerization of just two GS subunits, all GS form large, multi-oligomeric machines.
Maria A. Schumacher +4 more
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Loss of Müller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration [PDF]
Frontiers in Neuroanatomy, 2023 IntroductionA hallmark of photoreceptor degenerations is progressive, aberrant remodeling of the surviving retinal neurons and glia following photoreceptor loss.
Hallur Reynisson +7 more
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Glutamine Synthetase Contributes to the Regulation of Growth, Conidiation, Sclerotia Development, and Resistance to Oxidative Stress in the Fungus Aspergillus flavus [PDF]
Toxins, 2022 The basic biological function of glutamine synthetase (Gs) is to catalyze the conversion of ammonium and glutamate to glutamine. This synthetase also performs other biological functions. However, the roles of Gs in fungi, especially in filamentous fungi,
Sen Wang +6 more
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Congenital Glutamine Deficiency with Glutamine Synthetase Mutations [PDF]
New England Journal of Medicine, 2005 Glutamine synthetase plays a major role in ammonia detoxification, interorgan nitrogen flux, acid-base homeostasis, and cell signaling. We report on two unrelated newborns who had congenital human glutamine synthetase deficiency with severe brain malformations resulting in multiorgan failure and neonatal death.
Annick Toutain +11 more
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Heliorhodopsin binds and regulates glutamine synthetase activity [PDF]
PLoS Biology, 2022 Photoreceptors are light-sensitive proteins found in various organisms that respond to light and relay signals into the cells. Heliorhodopsin, a retinal-binding membrane protein, has been recently discovered, however its function remains unknown. Herein,
Shin-Gyu Cho +5 more
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Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for
BMC Evolutionary Biology, 2009 Background Although the gene encoding for glutamine synthetase (glnA) is essential in several organisms, multiple glnA copies have been identified in bacterial genomes such as those of the phylum Actinobacteria, notably the mycobacterial species ...
Wiid Ian JF +2 more
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cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish [PDF]
Journal of Cardiovascular Development and DiseaseCarnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng +4 more
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Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment [PDF]
Frontiers in Oncology, 2023 IntroductionGlutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function.MethodsDifferent types of myeloid cells were cultured in the absence or ...
Robert Schoeppe +21 more
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Glutamine versus ammonia utilization in the NAD synthetase family. [PDF]
PLoS ONE, 2012 NAD is a ubiquitous and essential metabolic redox cofactor which also functions as a substrate in certain regulatory pathways. The last step of NAD synthesis is the ATP-dependent amidation of deamido-NAD by NAD synthetase (NADS).
Jessica De Ingeniis +5 more
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