Loss of Müller cell glutamine synthetase immunoreactivity is associated with neuronal changes in late-stage retinal degeneration [PDF]
Frontiers in Neuroanatomy, 2023 IntroductionA hallmark of photoreceptor degenerations is progressive, aberrant remodeling of the surviving retinal neurons and glia following photoreceptor loss.
Hallur Reynisson +7 more
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M. mazei glutamine synthetase and glutamine synthetase-GlnK1 structures reveal enzyme regulation by oligomer modulation [PDF]
Nature Communications, 2023 Glutamine synthetases (GS) play central roles in cellular nitrogen assimilation. Although GS active-site formation requires the oligomerization of just two GS subunits, all GS form large, multi-oligomeric machines.
Maria A. Schumacher +4 more
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The Distinctive Regulation of Cyanobacterial Glutamine Synthetase [PDF]
Life, 2018 Glutamine synthetase (GS) features prominently in bacterial nitrogen assimilation as it catalyzes the entry of bioavailable nitrogen in form of ammonium into cellular metabolism. The classic example, the comprehensively characterized GS of enterobacteria,
Paul Bolay +3 more
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Heliorhodopsin binds and regulates glutamine synthetase activity. [PDF]
PLoS Biology, 2022 Photoreceptors are light-sensitive proteins found in various organisms that respond to light and relay signals into the cells. Heliorhodopsin, a retinal-binding membrane protein, has been recently discovered, however its function remains unknown. Herein,
Shin-Gyu Cho +5 more
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cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish [PDF]
Journal of Cardiovascular Development and DiseaseCarnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng +4 more
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Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment [PDF]
Frontiers in Oncology, 2023 IntroductionGlutamine deficiency is a well-known feature of the tumor environment. Here we analyzed the impact of glutamine deprivation on human myeloid cell survival and function.MethodsDifferent types of myeloid cells were cultured in the absence or ...
Robert Schoeppe +21 more
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Reassimilation of Photorespiratory Ammonium in Lotus japonicus Plants Deficient in Plastidic Glutamine Synthetase. [PDF]
PLoS ONE, 2015 It is well established that the plastidic isoform of glutamine synthetase (GS2) is the enzyme in charge of photorespiratory ammonium reassimilation in plants.
Carmen M Pérez-Delgado +3 more
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Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis
Cell ReportsSummary: Glutamine homeostasis plays a crucial role in fundamental cellular processes and is often dysregulated in cancer cells; however, the underlying mechanisms governing this homeostasis remain unclear.
Siyi Li +14 more
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Toxins, 2022 The basic biological function of glutamine synthetase (Gs) is to catalyze the conversion of ammonium and glutamate to glutamine. This synthetase also performs other biological functions. However, the roles of Gs in fungi, especially in filamentous fungi,
Sen Wang +6 more
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Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform. [PDF]
PLoS ONE, 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase.
A Theron +9 more
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