Results 91 to 100 of about 92,131 (300)

Male proband with intractable seizures and a de novo start-codon-disrupting variant in GLUL

HGG Advances
Summary: Bi-allelic variants in GLUL, encoding glutamine synthetase and responsible for the conversion of glutamate to glutamine, are associated with a severe recessive disease due to glutamine deficiency.
Elizabeth Carbonell, Sarah L. Stenton, Vijay S. Ganesh, Jialan Ma, Grace E. VanNoy, Lynn Pais, John N. Gaitanis, Melanie C. O’Leary, Heidi L. Rehm, Anne O’Donnell-Luria   +9 more
doaj   +1 more source

Effects of CO2 enrichment on photosynthesis, growth, and nitrogen metabolism of the seagrass Zostera noltii [PDF]

, 2012
Seagrass ecosystems are expected to benefit from the global increase in CO2 in the ocean because the photosynthetic rate of these plants may be C-i-limited at the current CO2 level.
Alexandre, Alexandre, Amthor, Andría, Beer, Beer, Cabaço, Caldeira, Corzo, Cousins, Duarte, Duarte, Feely, Fonseca, Furbank, Gao, Gao, García-Sánchez, Gattuso, Genty, Gordillo, Guinotte, Hall-Spencer, Hemminga, Invers, IPCC (Intergovernmental Panel on Climate Change), Jassby, Jiang, Liu, Magnusson, Marschner, Mercado, Mercado, Palacios, Parsons, Pelletier, Peralta, Porzio, Pörtner, Riebesell, Sagi, Santos, Semesi, Silva, Silva, Stitt, Taiz, Thom, Touchette, Ullrich, Vessey, Xu, Yelle, Zieman, Zimmerman, Zimmerman, Zou   +56 more
core   +1 more source

Astrocytes and Glutamine Synthetase in Epileptogenesis [PDF]

Journal of Neuroscience Research, 2018
AbstractThe cellular, molecular, and metabolic mechanisms that underlie the development of mesial temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes in epilepsy development (a.k.a. epileptogenesis), particularly astrocyte pathologies related to: aquaporin 4, the inwardly rectifying potassium channel Kir4.1 ...
Tore Eid, Tih‐Shih W. Lee, Peter Patrylo, Hitten P. Zaveri   +3 more
openaire   +2 more sources

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source

Importance of the ammonia assimilation by Penicillium purpurogenum in amino derivative Monascus pigment, PP-V, production [PDF]

, 2013
A fungal strain, Penicillium purpurogenum IAM 15392, produced the azaphilone Monascus pigment homolog when cultured in a medium composed of soluble starch, ammonium nitrate, yeast extract, and citrate buffer, pH 5.0. One of the typical features of violet
Jun Kato, Jun Ogihara, Kasumi Koganei, Ryo Kojima, Sara Umemura, Takafumi Kasumi, Teppei Arai   +6 more
core   +1 more source

Higher‐Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation

Advanced Science, EarlyView.
Solution structures of a series of cyclic lipodepsipeptides from Pseudomonas reveal that these specialized metabolites adopt left‐handed alpha helical conformations of only two types, being either ‘stapled’ or ‘catch‐pole’ helix. The particular modular distribution of the biosynthetic gene clusters is found to determine the extent of their conserved ...
Benjámin Kovács, Durga Prasad, Vic De Roo, Matthias Vanheede, Penthip Muangkaew, Annemieke Madder, Monica Höfte, René De Mot, Niels Geudens, José C. Martins   +9 more
wiley   +1 more source

Nitrogen assimilation in Citrus based on CitEST data mining

Genetics and Molecular Biology, 2007
Assimilation of nitrate and ammonium are vital procedures for plant development and growth. From these primary paths of inorganic nitrogen assimilation, this metabolism integrates diverse paths for biosynthesis of macromolecules, such as amino acids and ...
Ester Wickert, Jackson Marcondes, Manoel Victor Lemos, Eliana G.M. Lemos   +3 more
doaj   +1 more source

Blood glutamine synthetase signaling in alcohol use disorder and racial disparity [PDF]

, 2022
Lailun Nahar, Sarah E. Kaufman, Patrick G. Davis, Stephanie L. Saunders, Elizabeth A. Disbrow, James C. Patterson, Hyung Wook Nam   +6 more
openalex   +1 more source

Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 Ȃ resolution [PDF]

, 2006
Copyright @ 2006 International Union of CrystallographyThe PII signal transduction proteins GlnB and GlnK are implicated in the regulation of nitrogen assimilation in Escherichia coli and other enteric bacteria.
Alderton, D, Berrow, NS, Nichols, CE, Owens, RJ, Sainsbury, S, Saunders, NJ, Stammers, DK   +6 more
core   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source