Results 91 to 100 of about 216,468 (357)
Angewandte Chemie, EarlyView.A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski +7 more
wiley +2 more sources
Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production
Biomedicines, 2020 Ambient temperature can regulate the immune response and affect tumor growth. Although thermoneutral caging reduces tumor growth via immune activation, little attention has been paid to the tumorigenic effect of low temperature.
Eun-Ji Lee +8 more
doaj +1 more source
Novel Glutamate–Putrescine Ligase Activity in Haloferax mediterranei: A New Function for glnA-2 Gene
Biomolecules, 2021 The genome of the halophilic archaea Haloferax mediterranei contains three ORFs that show homology with glutamine synthetase (GS) (glnA-1, glnA-2, and glnA-3).
Verónica Rodríguez-Herrero +5 more
doaj +1 more source
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
core +4 more sources
Journal of Experimental Botany, 2015 Highlight The five HvGS1 and five HvASN genes identified in the barley genome are differentially expressed in barley leaves depending on senescence, nitrogen regime, and dark exposure.
Liliana Avila-Ospina +4 more
semanticscholar +1 more source
New perspectives on glutamine synthetase in grasses [PDF]
Journal of Experimental Botany, 2010 Members of the glutamine synthetase (GS) gene family have now been characterized in many crop species such as wheat, rice, and maize. Studies have shown that cytosolic GS isoforms are involved in nitrogen remobilization during leaf senescence and emphasized a role in seed production particularly in small grain crop species.
Swarbreck, S. M. +4 more
openaire +3 more sources
Advanced Science, EarlyView.Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal +15 more
wiley +1 more source
Advanced Science, EarlyView.Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan +9 more
wiley +1 more source
Glutamine synthetase gene evolution in bacteria. [PDF]
Molecular Biology and Evolution, 1995 The evolution of the prokaryotic glutamine synthase (GS) genes, namely the GSI and GSII isoforms, has been investigated using the second codon positions, which have previously proven to behave as a good molecular clock. Our data confirm the early divergence between prokaryotic and eukaryotic GSII before the splitting between plants and animals.
PESOLE, Graziano +3 more
openaire +4 more sources
Advanced Science, EarlyView.Polarization‐sensitive holotomography (PS‐HT) enables label‐free 3D imaging and quantitative analysis of lipid droplets by exploiting their intrinsic birefringence. Applied to prostate cell models, PS‐HT reveals glucose‐induced lipid accumulation in cancer cells and achieves near‐perfect classification of healthy and cancerous states.
Hossein Khadem +4 more
wiley +1 more source