Results 101 to 110 of about 216,468 (357)

Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity

Advanced Science, EarlyView.
In superficial second‐degree burn wounds, Gb3 turns on genes related to papillary cells through the FGF2 signaling pathway. This increases the ability of cells to break down fibrin and decreases fibrosis, which ultimately prevents scar formation in burn injuries.
Sujie Xie, Runzhi Huang, Weijin Qian, Xinran Ding, Wei Zhang, Yixu Li, Jianyu Lu, Hanlin Sun, Yifan Liu, Yuntao Yao, Bingnan Lu, Minjuan Wu, Zhaofan Xia, Shizhao Ji   +13 more
wiley   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus [PDF]

, 2016
Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of ...
Alonso-Carrion, Francisco Jose, Castilla, Laura, García-Bonilla, María, García-Martín, María Luisa, Gutierrez-Perez, Antonia, Jimenez-Lara, Antonio Jesus, Muñoz, Carmen, Márquez-Gómez, Javier, Peñalver, Ana, Shumilov, Kirill   +9 more
core  

Effects of CO2 enrichment on photosynthesis, growth, and nitrogen metabolism of the seagrass Zostera noltii [PDF]

, 2012
Seagrass ecosystems are expected to benefit from the global increase in CO2 in the ocean because the photosynthetic rate of these plants may be C-i-limited at the current CO2 level.
Alexandre, Alexandre, Amthor, Andría, Beer, Beer, Cabaço, Caldeira, Corzo, Cousins, Duarte, Duarte, Feely, Fonseca, Furbank, Gao, Gao, García-Sánchez, Gattuso, Genty, Gordillo, Guinotte, Hall-Spencer, Hemminga, Invers, IPCC (Intergovernmental Panel on Climate Change), Jassby, Jiang, Liu, Magnusson, Marschner, Mercado, Mercado, Palacios, Parsons, Pelletier, Peralta, Porzio, Pörtner, Riebesell, Sagi, Santos, Semesi, Silva, Silva, Stitt, Taiz, Thom, Touchette, Ullrich, Vessey, Xu, Yelle, Zieman, Zimmerman, Zimmerman, Zou   +56 more
core   +1 more source

Importance of the ammonia assimilation by Penicillium purpurogenum in amino derivative Monascus pigment, PP-V, production [PDF]

, 2013
A fungal strain, Penicillium purpurogenum IAM 15392, produced the azaphilone Monascus pigment homolog when cultured in a medium composed of soluble starch, ammonium nitrate, yeast extract, and citrate buffer, pH 5.0. One of the typical features of violet
Jun Kato, Jun Ogihara, Kasumi Koganei, Ryo Kojima, Sara Umemura, Takafumi Kasumi, Teppei Arai   +6 more
core   +1 more source

Astrocytes and glutamate homoeostasis in Alzheimer's disease: a decrease in glutamine synthetase, but not in glutamate transporter-1, in the prefrontal cortex

ASN Neuro, 2013
Astrocytes control tissue equilibrium and hence define the homoeostasis and function of the CNS (central nervous system). Being principal homoeostatic cells, astroglia are fundamental for various forms of neuropathology, including AD (Alzheimer's disease)
Magdalena Kulijewicz-Nawrot, E. Sykova, A. Chvátal, A. Verkhratsky, Jose Julio Rodriguez   +4 more
semanticscholar   +1 more source

Glutamine Synthetase and Glutamine Synthetase‐Like Protein from Human Brain [PDF]

Journal of Neurochemistry, 2000
Abstract: Glutamine synthetase (GS; EC 6.3.1.2), a key enzyme ofglutamate metabolism, and another enzyme possessing highhydroxylamine‐L‐glutamine transferase activity comparable to that of GS andtermed GS‐like protein (GSLP) were purified from human brain concurrently.
Gulnur Sh. Burbaeva, E B Tereshkina, I. S. Boksha   +2 more
openaire   +3 more sources

Balancing Cell Growth and Product Synthesis for Efficient Microbial Cell Factories

Advanced Science, EarlyView.
This review presents state‐of‐the‐art metabolic engineering strategies to balance microbial cell growth and product synthesis in biorefineries. It surveys pathway engineering, dynamic genetic circuits, orthogonal control systems, synthetic microbial consortia, and fermentation optimization, alongside integrative modeling approaches.
Linxia Liu, Dongqin Ding, Huiying Wang, Xinyi Ren, Sang Yup Lee, Dawei Zhang   +5 more
wiley   +1 more source

Male proband with intractable seizures and a de novo start-codon-disrupting variant in GLUL

HGG Advances
Summary: Bi-allelic variants in GLUL, encoding glutamine synthetase and responsible for the conversion of glutamate to glutamine, are associated with a severe recessive disease due to glutamine deficiency.
Elizabeth Carbonell, Sarah L. Stenton, Vijay S. Ganesh, Jialan Ma, Grace E. VanNoy, Lynn Pais, John N. Gaitanis, Melanie C. O’Leary, Heidi L. Rehm, Anne O’Donnell-Luria   +9 more
doaj   +1 more source

Glutamine Synthetase

Journal of Biological Chemistry, 1972
Glutamine synthetase (EC 6.3.1.2) was localized in the mitochondrial fractions of liver from three uricotelic species. These were chicken (Gallus domesticus), pigeon (Columba livia), and snake (Thamnophis elegans). In rat liver, glutamine synthetase is an extramitochondrial enzyme being mainly associated with microsomes during cellular fractionation ...
James W. Campbell, Jean E. Vorhaben
openaire   +3 more sources