Results 11 to 20 of about 91,004 (324)
The glutamine synthetase gene family in
BMC Plant Biology, 2011 Background Glutamine synthetase (GS; EC: 6.3.1.2, L-glutamate: ammonia ligase ADP-forming) is a key enzyme in ammonium assimilation and metabolism of higher plants.
Cánovas Francisco M +5 more
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A revised view on the evolution of glutamine synthetase isoenzymes in plants. [PDF]
Plant J, 2022 Valderrama-Martín JM +6 more
europepmc +3 more sources
Congenital glutamine deficiency with glutamine synthetase mutations [PDF]
New England Journal of Medicine, 2006 Jalan, Rajiv, Rose, Christopher
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Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform. [PDF]
PLoS ONE, 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase.
A Theron +9 more
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Glutamine Synthetase Sensitivity to Oxidative Modification during Nutrient Starvation in Prochlorococcus marinus PCC 9511. [PDF]
PLoS ONE, 2015 Glutamine synthetase plays a key role in nitrogen metabolism, thus the fine regulation of this enzyme in Prochlorococcus, which is especially important in the oligotrophic oceans where this marine cyanobacterium thrives.
Guadalupe Gómez-Baena +4 more
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Visualized Cancer Medicine, 2023 A recent report published in Nature Metabolism identified that glutamine synthetase (GS), the only enzyme in mammals to produce glutamine from glutamate, can directly control cancer cell mitosis by governing the APC/C complex via a metabolism-independent
Zhao Jiang-Sha +3 more
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Frontiers in Molecular Biosciences, 2022 Cellular glutamine synthesis is thought to be an important resistance factor in protecting cells from nutrient deprivation and may also contribute to drug resistance.
Șafak Bayram +10 more
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Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase. [PDF]
Proceedings of the National Academy of Sciences, 1975 We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of
F, Foor, K A, Janssen, B, Magasanik
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Astrocytes and Glutamine Synthetase in Epileptogenesis [PDF]
Journal of Neuroscience Research, 2018 AbstractThe cellular, molecular, and metabolic mechanisms that underlie the development of mesial temporal lobe epilepsy are incompletely understood. Here we review the role of astrocytes in epilepsy development (a.k.a. epileptogenesis), particularly astrocyte pathologies related to: aquaporin 4, the inwardly rectifying potassium channel Kir4.1 ...
Tore Eid +3 more
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Bone Research, 2022 Ammonia plays an important role in cellular metabolism. However, ammonia is considered a toxic product. In bone marrow-derived mesenchymal stem cells, multipotent stem cells with high expression of glutamine synthetase (GS) in bone marrow, ammonia and ...
Yu Liu +12 more
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