Results 21 to 30 of about 92,131 (300)

Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase. [PDF]

Proceedings of the National Academy of Sciences, 1975
We have examined three mutants of Klebsiella aerogenes whose genetic lesions (glnB, glnD, and glnE) are in loci unlinked to the structural gene for glutamine sythetase (glnA) and in which the control of both the level and state of adenylylation of glutamine synthetase is altered. Each mutation alters a different component of the adenylylation system of
F, Foor, K A, Janssen, B, Magasanik
openaire   +2 more sources

Pea Leaf Glutamine Synthetase [PDF]

Plant Physiology, 1975
Of a variety of purine and pyrimidine nucleotides tested, only ADP and 5'AMP significantly inhibited the Mg(2+)-dependent activity of pea leaf glutamine synthetase. They were less effective inhibitors where Mn(2+) replaced Mg(2+). They were competitive inhibitors with respect to ATP, with inhibition constant (Ki) values of 1.2 and 1.8 mm, respectively.
T D, O'neal, K W, Joy
openaire   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Possibility of medicinal correction of disorders in metabolic cycle of neurotoxic transmitter glutamate in retina with neurotropic drugs during experimental glaucoma

Patologìâ, 2012
Adult rabbits with experimental glaucoma were used in this study. We studied glutamate and glutamine levels and glutamine synthetase, glutamate oxidase and glutaminase activity in the eye tissue during glaucoma process.
V. M. Serdyuk
doaj   +1 more source

New isoforms and assembly of glutamine synthetase in the leaf of wheat (Triticum aestivum L.). [PDF]

, 2015
Glutamine synthetase (GS; EC 6.3.1.2) plays a crucial role in the assimilation and re-assimilation of ammonia derived from a wide variety of metabolic processes during plant growth and development.
Ma, Xinming, Shi, Lanxin, Theg, Steven M, Wang, Xiaochun, Wei, Yihao   +4 more
core   +1 more source

Glutamine versus ammonia utilization in the NAD synthetase family. [PDF]

PLoS ONE, 2012
NAD is a ubiquitous and essential metabolic redox cofactor which also functions as a substrate in certain regulatory pathways. The last step of NAD synthesis is the ATP-dependent amidation of deamido-NAD by NAD synthetase (NADS).
Jessica De Ingeniis, Marat D Kazanov, Konstantin Shatalin, Mikhail S Gelfand, Andrei L Osterman, Leonardo Sorci   +5 more
doaj   +1 more source

Genes for asparagine metabolism in Lotus japonicus : differential expression and interconnection with photorespiration [PDF]

, 2017
Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability.
Betti, Marco, Credali, Alfredo, García Calderón, Margarita, Márquez Cabeza, Antonio José, Pérez Delgado de Torres, Carmen María, Vega Piqueres, José María   +5 more
core   +1 more source

Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase

Cell Reports, 2019
Summary: Glutamate has been implicated in a wide range of brain pathologies and is thought to be metabolized via the astrocyte-specific enzyme glutamine synthetase (GS).
Wendy Xin, Yevgeniya A. Mironova, Hui Shen, Rosa A.M. Marino, Ari Waisman, Wouter H. Lamers, Dwight E. Bergles, Antonello Bonci   +7 more
doaj   +1 more source

Glutamine Synthetase and Glutamine Synthetase‐Like Protein from Human Brain [PDF]

Journal of Neurochemistry, 2000
Abstract: Glutamine synthetase (GS; EC 6.3.1.2), a key enzyme ofglutamate metabolism, and another enzyme possessing highhydroxylamine‐L‐glutamine transferase activity comparable to that of GS andtermed GS‐like protein (GSLP) were purified from human brain concurrently.
I S, Boksha, E B, Tereshkina, G S, Burbaeva   +2 more
openaire   +2 more sources

Dexamethasone enhances glutamine synthetase activity and reduces N-methyl-D-aspartate neurotoxicity in mixed cultures of neurons and astrocytes

AIMS Molecular Science, 2015
Astrocytes are claimed to protect neurons against excitotoxicity by clearing glutamate from the extracellular space and rapidly converting it into glutamine.
Edith Debroas, Carine Ali, Dominique Duval   +2 more
doaj   +1 more source