Results 41 to 50 of about 78,410 (212)

PHOSPHO1 Suppresses Ferroptosis in Retinal Pigment Epithelial Cells by Reducing the Levels of Phosphatidylethanolamine Molecular Species

Advanced Science, EarlyView.
Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen, Xiaoman Zhu, Michael Mingze Lu, Qingjian Ou, Xueying Wang, Zhenzhen Zhao, Qi Shen, Qian Wang, Zhe Wang, Jing‐Ying Xu, Caixia Jin, Furong Gao, Juan Wang, Jingfa Zhang, Jieping Zhang, Xiaoliang Jin, Yanlong Bi, Lixia Lu, Guo‐Tong Xu, Haibin Tian   +19 more
wiley   +1 more source

Delaying chloroplast turnover increases water-deficit stress tolerance through the enhancement of nitrogen assimilation in rice. [PDF]

, 2017
Abiotic stress-induced senescence in crops is a process particularly affecting the photosynthetic apparatus, decreasing photosynthetic activity and inducing chloroplast degradation.
Blumwald, Eduardo, Rubio Wilhelmi, Maria Del Mar, Sade, Nir, Umnajkitikorn, Kamolchanok, Wang, Songhu, Wright, Matthew   +5 more
core   +1 more source

Glutamine synthetase gene evolution in bacteria. [PDF]

Molecular Biology and Evolution, 1995
The evolution of the prokaryotic glutamine synthase (GS) genes, namely the GSI and GSII isoforms, has been investigated using the second codon positions, which have previously proven to behave as a good molecular clock. Our data confirm the early divergence between prokaryotic and eukaryotic GSII before the splitting between plants and animals.
PESOLE, Graziano, GISSI, CARMELA, LANAVE C, SACCONE C.   +3 more
openaire   +4 more sources

Benefit from Biomass Boiler Emissions to Increase Greenhouse CO2 Levels for Optimal Growth and Yield in Tomato, Cucumber, and Strawberry

Advanced Energy and Sustainability Research, EarlyView.
Using CO2‐rich polluting gases in greenhouse plant cultivation has proven to be a promising technique for stimulating plants while reducing emissions to the atmosphere. The use of an experimental biofilter proves to be effective in retaining most of the toxic particles. The alteration of physiological and metabolic parameters shows an adaptation of the
Alberto Martinez‐Alonso, Jose Fermoso, Francisco Verdugo, Micaela Carvajal   +3 more
wiley   +1 more source

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase

Biotechnology Progress, EarlyView.
Abstract We present the first use of a bioengineered mammalian transposase system derived from Myotis lucifugus (bMLT) for integration of expression vectors into the CHO genome, focusing on GFP and trastuzumab production. Initially, CHO‐K1 cells are transfected with a GFP reporter and varying amounts of bMLT DNA or mRNA.
Nicolas Marx, Anna‐Maria Otte, Klaus Leitner, Rehmadanta Sitepu, Thomas Berger, Veronika Schäpertöns, Christian G. Huber, Quan Zhu, Sandeep Nema, Joseph J. Higgins, Nicole Borth   +10 more
wiley   +1 more source

Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster? [PDF]

, 2019
Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production.
Jiang, Jie, Srivastava, Sankalp, Zhang, Ji   +2 more
core   +1 more source

Improving outcomes in intensified processing via optimization of the cell line development workflow

Biotechnology Progress, EarlyView.
Abstract As the industry continues to explore the benefits of continuous and intensified manufacturing, it is important to assure that the cell line development (CLD) workflows in practice today are well suited to generate clones that meet the unique challenges associated with these processes. Most cell lines used in intensified processes are currently
Vincent Balassi, Mary Otto, Corey Kretzmer, Amber Petersen, Channing McLaurin, Jana Mahadevan, Jason Gustin, Trissa Borgschulte, David Razafsky   +8 more
wiley   +1 more source

Effect of Ammonium-supplemented Seawater on Glutamine Synthetase and Glutamate Dehydrogenase Activities in Host Tissue and Zooxanthellae of Pocillopora damicornis and on Ammonium Uptake Rates of the Zooxanthellae [PDF]

, 1994
Host glutamine synthetase activity decreases in Pocillopora damicornis (Linnaeus) following exposure of the coral to seawater containing elevated ammonium (20 uM).
Fitt, W.K., Rees, TAV, Yellowlees, D.
core  

N‐1 semi‐continuous transient perfusion in shake flask for ultra‐high density seeding of CHO cell cultures in benchtop bioreactors

Biotechnology Progress, EarlyView.
Abstract One strategy to enhance the production of biological therapeutics is using transient perfusion in the preculture (N‐1 stage) to seed the production culture (N stage) at ultra‐high cell densities (>10 x 106 viable cells/mL). This very high seeding density improves cell culture performance by shortening the timeline and/or achieving higher final
Lucas Lemire, Sebastian‐Juan Reyes, Yves Durocher, Robert Voyer, Olivier Henry, Phuong Lan Pham   +5 more
wiley   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources