New isoforms and assembly of glutamine synthetase in the leaf of wheat (Triticum aestivum L.). [PDF]
, 2015 Glutamine synthetase (GS; EC 6.3.1.2) plays a crucial role in the assimilation and re-assimilation of ammonia derived from a wide variety of metabolic processes during plant growth and development.
Ma, Xinming +4 more
core +1 more source
A glutamine riboswitch is a key element for the regulation of glutamine synthetase in cyanobacteria
Nucleic Acids Research, 2018 As the key enzyme of bacterial nitrogen assimilation, glutamine synthetase (GS) is tightly regulated. In cyanobacteria, GS activity is controlled by the interaction with inactivating protein factors IF7 and IF17 encoded by the genes gifA and gifB ...
Stephan Klähn +7 more
semanticscholar +1 more source
Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase
Cell Reports, 2019 Summary: Glutamate has been implicated in a wide range of brain pathologies and is thought to be metabolized via the astrocyte-specific enzyme glutamine synthetase (GS).
Wendy Xin +7 more
doaj +1 more source
Reduced glutamine synthetase activity alters the fecundity of female Bactrocera dorsalis (Hendel) [PDF]
, 2019 Glutamine synthetase (GS) is a key enzyme in glutamine synthesis and is associated with multiple physiological processes in insects, such as embryonic development, heat shock response, and fecundity regulation.
Smagghe, Guy +5 more
core +2 more sources
AIMS Molecular Science, 2015 Astrocytes are claimed to protect neurons against excitotoxicity by clearing glutamate from the extracellular space and rapidly converting it into glutamine.
Edith Debroas +2 more
doaj +1 more source
Leukemia Cells Resistant to Glutamine Deprivation Express Glutamine Synthetase Protein
Turkish Journal of Hematology, 2022 Objective: Low glutamine levels have been shown in tumor environments for several cancer subtypes. Therefore, it has been suggested that cancer cells rewire their metabolism to adopt low nutrient levels for survival and proliferation.
Burcu Yücel, Saniye Ada
doaj +1 more source
In vitro suppression of inflammatory cytokine response by methionine sulfoximine
Journal of Inflammation, 2018 Background The glutamine synthetase inhibitor methionine sulfoximine (MSO), shown previously to prevent death caused by an inflammatory liver response in mice, was tested on in vitro production of cytokines by mouse peritoneal macrophages triggered with ...
Tyler J. Peters +2 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Glutamate is the main excitatory amino acid acting at the level of pre and postsynaptic neurons, as well as in glial cells. It is involved in the coordinated modulation of energy metabolism, glutamine synthesis, and ammonia detoxification.
Catya Jiménez-Torres +5 more
doaj +1 more source
Genes for asparagine metabolism in Lotus japonicus : differential expression and interconnection with photorespiration [PDF]
, 2017 Background: Asparagine is a very important nitrogen transport and storage compound in plants due to its high nitrogen/carbon ratio and stability.
Betti, Marco +5 more
core +1 more source
Glutamine metabolic reprogramming in hepatocellular carcinoma
Frontiers in Molecular Biosciences, 2023 Hepatocellular carcinoma (HCC) is a lethal disease with limited management strategies and poor prognosis. Metabolism alternations have been frequently unveiled in HCC, including glutamine metabolic reprogramming.
Yanyan Ye +6 more
doaj +1 more source