Results 121 to 130 of about 821 (130)

Computational evidence for the catalytic mechanism of glutaminyl cyclase. A DFT investigation

Proteins: Structure, Function, and Bioinformatics, 2008
AbstractThe results of a DFT theoretical investigation on the catalytic mechanism of the QC enzyme are presented. A rather large model‐system is used. It includes the most important residues that are believed to play a key‐role in the catalysis.
CALVARESI, MATTEO, GARAVELLI, MARCO, BOTTONI, ANDREA   +2 more
openaire   +2 more sources

Glutaminyl Cyclases

2013
Holger Cynis, Stephan Schilling, Hans-Ulrich Demuth   +2 more
openaire   +1 more source

Hybrid descriptors–conjoint indices: a case study on imidazole-thiourea containing glutaminyl cyclase inhibitors for design of novel anti-Alzheimer’s candidates

SAR and QSAR in Environmental Research, 2023
Parvin Kumar
exaly  

Crystal Structure and Functional Analysis of the Glutaminyl Cyclase from Xanthomonas campestris

Journal of Molecular Biology, 2010
Andrew H -J Wang, Tzu-Ping Ko, Kai-Fa Huang   +2 more
exaly  

Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice

International Immunopharmacology, 2019
Zhigang Liu, Zhen-Dan He, Haiqiang Wu
exaly  

The Development of Small Molecule Inhibitors of Glutaminyl Cyclase and Isoglutaminyl Cyclase for Alzheimer's Disease

ChemistrySelect, 2019
Ying Qu, Jing-De Wu
exaly  

Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

Bioorganic and Medicinal Chemistry, 2013
Phuong-Thao Tran, Van-Hai Hoang, Jihyae Ann   +2 more
exaly  

Absence of an essential thiol in human glutaminyl cyclase: Implications for mechanism

Korean Journal of Biological Sciences, 1998
Robert C Bateman Jr
exaly  

Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: A single zinc metalloenzyme

Protein Expression and Purification, 2005
Kai-Fa Huang, Andrew H -J Wang
exaly  

Improved determination of bovine glutaminyl cyclase activity using precolumn derivatization and reversed-phase high-performance liquid chromatography with ultraviolet detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2004
exaly