Results 101 to 110 of about 821 (130)
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Snake venom glutaminyl cyclase
Toxicon, 2006Glutaminyl cyclase (QC) catalyzes N-terminal glutamine cyclization of many endocrine peptides and is typically abundant in brain tissue. As three-finger toxins in the venoms of colubrid snakes Boiga dendrophila and Boiga irregularis contain N-terminal pyroglutamate, we searched for QC in venom glands of both snakes.
R Manjunatha Kini
exaly +3 more sources
Inhibitory effect of flavonoids on human glutaminyl cyclase
Bioorganic and Medicinal Chemistry, 2016Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4' (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC ...
Xi Yu, Zhen-Dan He, Haiqiang Wu
exaly +3 more sources
Glutaminyl-Cyclase Expression in the Bovine/Porcine Hypothalamus and Pituitary
Journal of Neuroendocrinology, 1995AbstractThe expression of the glutaminyl cyclase (QC), an enzyme responsible for the post‐translational modification of N‐terminal pyroglutamyl residues of neuropeptide precursors, was examined in bovine/porcine hypothalamic and pituitary tissue by means of immunocytochemistry and in situ hybridization.
T M, Böckers, M R, Kreutz, T, Pohl
exaly +3 more sources
Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain
International Journal of Developmental Neuroscience, 2009AbstractGlutaminyl cyclase (QC) converts N‐terminal glutaminyl residues into pyroglutamate (pE), thereby stabilizing these peptides/proteins. Recently, we demonstrated that QC also plays a pathogenic role in Alzheimer's disease by generating the disease‐associated pE‐Abeta from N‐terminally truncated Abeta peptides in vivo.
Holger Cynis +2 more
exaly +3 more sources
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
Nature Medicine, 2008Because of their abundance, resistance to proteolysis, rapid aggregation and neurotoxicity, N-terminally truncated and, in particular, pyroglutamate (pE)-modified Abeta peptides have been suggested as being important in the initiation of pathological cascades resulting in the development of Alzheimer's disease. We found that the N-terminal pE-formation
Stephan Schilling +2 more
exaly +3 more sources
Glutaminyl Cyclase, Diseases, and Development of Glutaminyl Cyclase Inhibitors
Journal of Medicinal Chemistry, 2021Pyroglutamate (pE) modification, catalyzed mainly by glutaminyl cyclase (QC), is prevalent throughout nature and is particularly important in mammals including humans for the maturation of hormones, peptides, and proteins. In humans, the upregulation of QC is involved in multiple diseases and conditions including Alzheimer's disease, Huntington's ...
Chenshu Xu, Yi-nan Wang, Haiqiang Wu
openaire +2 more sources
Journal of Molecular Biology, 2006
Glutaminyl cyclases (QCs) (EC 2.3.2.5) catalyze the intramolecular cyclization of protein N-terminal glutamine residues into pyroglutamic acid with the concomitant liberation of ammonia. QCs may be classified in two groups containing, respectively, the mammalian enzymes, and the enzymes from plants, bacteria, and parasites. The crystal structure of the
Wintjens, René +7 more
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Glutaminyl cyclases (QCs) (EC 2.3.2.5) catalyze the intramolecular cyclization of protein N-terminal glutamine residues into pyroglutamic acid with the concomitant liberation of ammonia. QCs may be classified in two groups containing, respectively, the mammalian enzymes, and the enzymes from plants, bacteria, and parasites. The crystal structure of the
Wintjens, René +7 more
openaire +2 more sources
Continuous Spectrometric Assays for Glutaminyl Cyclase Activity
Analytical Biochemistry, 2002The enzymatic conversion of one chromogenic substrate, l-glutamine-p-nitroanilide, and two fluorogenic substrates, l-glutaminyl-2-naphthylamide and l-glutaminyl-4-methylcoumarinylamide, into their respective pyroglutamic acid derivatives by glutaminyl cyclase (QC) was estimated by introducing a new coupled assay using pyroglutamyl aminopeptidase as the
Stephan, Schilling +5 more
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Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase
Biological Chemistry, 2021Abstract Porphyromonas gingivalis is a bacterial species known to be involved in the pathogenesis of chronic periodontitis, that more recently has been as well associated with Alzheimer’s disease. P. gingivalis expresses a glutaminyl cyclase (PgQC) whose human ortholog is known to participate in the beta amyloid ...
Sebastiaan Lamers +7 more
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Glutaminyl cyclases, the potential targets of cancer and neurodegenerative diseases
European Journal of Pharmacology, 2022Glutaminyl cyclases (QC) catalyze the cyclization of proteins and turn N-terminal glutamine or glutamic acid into N-terminal pyroglutamate, resulting in protection of proteins from aminopeptidases and an increase of their stabilities. The aberrant N-terminal pyroglutamate has been found in various diseases, including Alzheimer's disease (AD ...
Yidan Zhang +6 more
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