Results 81 to 90 of about 821 (130)

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. [PDF]

Nat Med, 2019
Logtenberg MEW, Jansen JHM, Raaben M, Toebes M, Franke K, Brandsma AM, Matlung HL, Fauster A, Gomez-Eerland R, Bakker NAM, van der Schot S, Marijt KA, Verdoes M, Haanen JBAG, van den Berg JH, Neefjes J, van den Berg TK, Brummelkamp TR, Leusen JHW, Scheeren FA, Schumacher TN.   +20 more
europepmc   +1 more source

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis. [PDF]

Cell Res, 2019
Wu Z, Weng L, Zhang T, Tian H, Fang L, Teng H, Zhang W, Gao J, Hao Y, Li Y, Zhou H, Wang P.   +11 more
europepmc   +1 more source

Synthesis and Evaluation of a Novel PET Radioligand for Imaging Glutaminyl Cyclase Activity as a Biomarker for Detecting Alzheimer's Disease. [PDF]

ACS Sens
Behof WJ, Haynes JR, Whitmore CA, Cheung YY, Tantawy MN, Peterson TE, Wijesinghe P, Matsubara JA, Pham W.   +8 more
europepmc   +1 more source

Varoglutamstat: Inhibiting Glutaminyl Cyclase as a Novel Target of Therapy in Early Alzheimer's Disease. [PDF]

J Alzheimers Dis
Feldman HH, Messer K, Qiu Y, Sabbagh M, Galasko D, Turner RS, Lopez O, Smith A, Durant J, Lupo JL, Revta C, Balasubramanian A, Kuehn-Wache K, Wassmann T, Schell-Mader S, Jacobs DM, Salmon DP, Léger G, DeMarco ML, Weber F, ADCS VIVA-MIND Study Group.   +20 more
europepmc   +1 more source

Structure, Mechanism and Inhibition of the human Glutaminyl Cyclase [PDF]

, 2022
openaire   +1 more source

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects. [PDF]

Alzheimers Dement (N Y), 2015
Lues I, Weber F, Meyer A, Bühring U, Hoffmann T, Kühn-Wache K, Manhart S, Heiser U, Pokorny R, Chiesa J, Glund K.   +10 more
europepmc   +1 more source

Glutaminyl cyclase inhibition reduces Alzheimer disease pathology and symptoms [PDF]

Nature Clinical Practice Neurology, 2009
openaire   +1 more source

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. [PDF]

Acta Crystallogr F Struct Biol Commun, 2015
DiPisa F, Pozzi C, Benvenuti M, Andreini M, Marconi G, Mangani S.   +5 more
europepmc   +1 more source

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion. [PDF]

Neurodegener Dis, 2014
Cynis H, Funkelstein L, Toneff T, Mosier C, Ziegler M, Koch B, Demuth HU, Hook V.   +7 more
europepmc   +1 more source

Synthesis and evaluation of [¹¹C]PBD150, a radiolabeled glutaminyl cyclase inhibitor for the potential detection of Alzheimer's disease prior to amyloid β aggregation. [PDF]

Medchemcomm, 2015
Brooks AF, Jackson IM, Shao X, Kropog GW, Sherman P, Quesada CA, Scott PJ.   +6 more
europepmc   +1 more source