Glutaminyl cyclase - Open Access .click

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Structural Impact of N‐terminal Pyroglutamate in an Amyloid‐β(3‐42) Fibril Probed by Solid‐State NMR Spectroscopy

Chemistry – A European Journal, Volume 30, Issue 10, February 16, 2024.
Solid state NMR spectroscopy on fibrils of recombinant, pyroglutamylated [U‐13C,15N]‐ pEAβ(3‐42) show highly similar β‐strand positions and a conserved turn region around V24 comparable to LS‐shaped Aβ(1‐42) fibrils. Due to missing D1‐A2 and pE3 formation a salt bridge of K28‐D1' is absent in pEAβ(3‐42) fibrils.
Luis Gardon +3 more
wiley +1 more source

Increased QPCT gene expression by the hepatitis B virus promotes HBV replication.

PLoS ONE
Glutamine cyclase, an enzyme involved in posttranslational modifications, is encoded by the glutaminyl-peptide cyclotransferase (QPCT) gene. Gene microarray analysis revealed that the QPCT gene was highly expressed in HepG2.2.15 cells compared with that ...
Conghui Zhang +7 more
doaj +1 more source

Baricitinib and tofacitinib off‐target profile, with a focus on Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 10, Issue 1, January‐March 2024.
Abstract INTRODUCTION Janus kinase (JAK) inhibitors were recently identified as promising drug candidates for repurposing in Alzheimer's disease (AD) due to their capacity to suppress inflammation via modulation of JAK/STAT signaling pathways. Besides interaction with primary therapeutic targets, JAK inhibitor drugs frequently interact with unintended,
Maria L. Faquetti +8 more
wiley +1 more source

A novel strategy for the management of non-productive cough: mechanisms, efficacy, safety. A review

Терапевтический архив
Cough, as a protective reflex, can become hypersensitive under pathological conditions (e.g. acute respiratory viral infections, acute bronchitis, asthma), significantly impairing patients’ quality of life.
Oleg V. Kalyuzhin, Andrey G. Malyavin
doaj +1 more source

Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions. [PDF]