Results 51 to 60 of about 821 (130)

Monogalactosyldiacylglycerol and Sulfolipid Synthesis in Microalgae

Marine Drugs, 2020
Microalgae, due to their huge taxonomic and metabolic diversity, have been shown to be a valuable and eco-friendly source of bioactive natural products.
Gennaro Riccio, Daniele De Luca, Chiara Lauritano   +2 more
doaj   +1 more source

Primary structure and functional expression of a glutaminyl cyclase. [PDF]

Proceedings of the National Academy of Sciences, 1991
A glutaminyl cyclase (QC) that is probably involved in the biosynthesis of pyroglutamyl peptides such as gonadotropin-releasing hormone and thyrotropin-releasing hormone has been purified to homogeneity from bovine anterior pituitary. On the basis of N-terminal sequence analysis, a 2088-base-pair cDNA clone was isolated from a bovine anterior pituitary
T, Pohl, M, Zimmer, K, Mugele, J, Spiess
openaire   +2 more sources

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site

Biology Direct, 2020
Background The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal propeptide with a defined sequence ...
Chinh Tran-To Su, Swati Sinha, Birgit Eisenhaber, Frank Eisenhaber   +3 more
doaj   +1 more source

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

The VIVA‐MIND study: Topline Results from Phase 2 RCT of Varoglutamstat in Early AD

Alzheimer's &Dementia, Volume 21, Issue S5, December 2025.
Abstract Background Varoglutamstat (PQ912) is an oral small molecule inhibitor of glutaminyl cyclases which reduces the pyroglutamate formation of Aβ and CCL2. Preclinical and Ph1 trials support this Ph2 evaluation in early AD. Our objectives included selecting the highest safe and well‐tolerated dose of varoglutamstat with futility analysis at 24 ...
Howard H. Feldman, Karen Messer, Jing Zhang, Natalie E Quach, Gabriel C Leger, Diane M. Jacobs, Steven D Edland, Jasmin Duehring, Andrew MacKelfresh, Alessandra Pol, Carolyn Revta, Jody‐Lynn Lupo, Archana Balasubramanian, Nicola Lama, Tanja Wassmann, Michael Schaeffer, Antje Meyer, Sylvia Schell‐Mader, Christine Wenzkowski, Frank Weber, ADCS VIVA‐MIND Study Group   +20 more
wiley   +1 more source

Quantitative N‐ or C‐Terminal Labelling of Proteins with Unactivated Peptides by Use of Sortases and a d‐Aminopeptidase

Angewandte Chemie, Volume 136, Issue 8, February 19, 2024.
A generalised coupling strategy to enable quantitative N‐ and C‐terminal labelling of proteins using unmodified peptides and readily produced catalysts is described. For C‐terminal labelling, a small excess of the labelling peptide is required, but for N‐terminal labelling, equimolar quantities of labelling reagents can be used to achieve quantitative ...
Zoe L. P. Arnott, Holly E. Morgan, Kristian Hollingsworth, Charlotte M. E. Stevenson, Lawrence J. Collins, Alexandra Tamasanu, Darren C. Machin, Jonathan P. Dolan, Tomasz P. Kamiński, Gemma C. Wildsmith, Daniel J. Williamson, Isabelle B. Pickles, Stuart L. Warriner, W. Bruce Turnbull, Michael E. Webb   +14 more
wiley   +2 more sources

Continuous assays of glutaminyl cyclase: from development to application [PDF]

Journal of Spectroscopy, 2004
Glutaminyl cyclase (QC, EC 2.3.2.5) catalyses the formation of pyroglutamyl residues from glutamine at the N‐terminus of peptides and proteins. In previously applied assays, QC activity was determined by either analysing the products formed using HPLC coupled with photometric or fluorometric detection, radioimmunoassay, or by detecting the release of ...
Stephan Schilling, Hans-Ulrich Demuth
openaire   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source