Results 41 to 50 of about 821 (130)

A MD Simulation Prediction for Regulation of N-Terminal Modification on Binding of CD47 to CD172a in a Force-Dependent Manner

Molecules, 2023
Cancer cells can evade immune surveillance through binding of its transmembrane receptor CD47 to CD172a on myeloid cells. CD47 is recognized as a promising immune checkpoint for cancer immunotherapy inhibiting macrophage phagocytosis.
Yang Zhao, Liping Fang, Pei Guo, Ying Fang, Jianhua Wu   +4 more
doaj   +1 more source

Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA

Marine Drugs, 2023
The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Yanli Liu, Zitong Zhao, Yunyang Song, Yifeng Yin, Fanghui Wu, Hui Jiang   +5 more
doaj   +1 more source

Venomics and antivenomics of the poorly studied Brazil’s lancehead, Bothrops brazili (Hoge, 1954), from the Brazilian State of Pará [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: The Brazil’s lancehead, Bothrops brazili, is a poorly studied pit viper distributed in lowlands of the equatorial rainforests of southern Colombia, northeastern Peru, eastern Ecuador, southern and southeastern Venezuela, Guyana, Suriname ...
Libia Sanz, Alicia Pérez, Sarai Quesada-Bernat, Rafaela Diniz-Sousa, Leonardo A. Calderón, Andreimar M. Soares, Juan J. Calvete, Cleópatra A. S. Caldeira   +7 more
doaj   +1 more source

Cellular response to β‐amyloid neurotoxicity in Alzheimer's disease and implications in new therapeutics

Animal Models and Experimental Medicine, 2023
β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD). Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions.
Haolin Zhang, Xianghua Li, Xiaoli Wang, Jiayu Xu, Felice Elefant, Juan Wang   +5 more
doaj   +1 more source

The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates

Frontiers in Microbiology, 2018
Bacteroidetes feature prominently in the human microbiome, as major colonizers of the gut and clinically relevant pathogens elsewhere. Here, we reveal a new Bacteroidetes specific feature in the otherwise widely conserved Sec/SPI (Sec translocase/signal ...
Matthias Bochtler, Matthias Bochtler, Danuta Mizgalska, Florian Veillard, Magdalena L. Nowak, John Houston, Paul Veith, Eric C. Reynolds, Jan Potempa, Jan Potempa   +9 more
doaj   +1 more source

Increased glutaminyl cyclase activity in brains of Alzheimer’s disease individuals

Journal of Neurochemistry, 2020
AbstractGlutaminyl cyclases (QC) catalyze the formation of neurotoxic pGlu‐modified amyloid‐β peptides found in the brains of people with Alzheimer's disease (AD). Reports of several‐fold increases in soluble QC (sQC) expression in the brain and peripheral circulation of AD individuals has prompted the development of QC inhibitors as potential AD ...
Adam P. Gunn, Bruce X. Wong, Catriona McLean, Chris Fowler, Peter J. Barnard, James A. Duce, Blaine R. Roberts   +6 more
openaire   +4 more sources

Glutaminyl Cyclases as Novel Targets for the Treatment of Septic Arthritis [PDF]

The Journal of Infectious Diseases, 2012
Septic arthritis is a severe and rapidly debilitating disease mainly caused by Staphylococcus aureus. Here, we assess the antiarthritic efficiency of glutaminyl cyclase (QC) inhibitors.Mice were inoculated with an arthritogenic amount of S. aureus intravenously or by local administration into the knee joint.
A. Hellvard, K. Maresz, S. Schilling, S. Graubner, U. Heiser, R. Jonsson, H. Cynis, H.-U. Demuth, J. Potempa, P. Mydel   +9 more
openaire   +3 more sources

Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death

Neurobiology of Disease, 2014
Disruption of neuronal networks in the Alzheimer-afflicted brain is increasingly recognized as a key correlate of cognitive and memory decline in Alzheimer patients.
H. Lison, M.F.K. Happel, F. Schneider, K. Baldauf, S. Kerbstat, B. Seelbinder, J. Schneeberg, M. Zappe, J. Goldschmidt, E. Budinger, U.H. Schröder, F.W. Ohl, S. Schilling, H.-U. Demuth, H. Scheich, K.G. Reymann, R. Rönicke   +16 more
doaj   +1 more source

Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers

Bioorganic Chemistry, 2015
Phosphate ions and glutaminyl cyclase (QC) both catalyze the formation of pyroglutamate (pE, pGlu) from N-terminal glutamine residues of peptides and proteins. Here, we studied the mechanism of glutamine cyclization using kinetic secondary deuterium and solvent isotope effects.
Franziska Seifert, Hans-Ulrich Demuth, Teresa Weichler, Hans-Henning Ludwig, Kai Tittmann, Stephan Schilling   +5 more
openaire   +3 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source