Results 61 to 70 of about 821 (130)

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, Volume 157, Issue 7, Page 1304-1315, 1 October 2025.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin, Chang Che, Aimin Jiang, Chang Qi, Antonino Glaviano, Zhijie Zhao, Zhirou Zhang, Zaoqu Liu, Ziyao Zhou, Quan Cheng, Shuofeng Yuan, Peng Luo   +11 more
wiley   +1 more source

A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology.

PLoS ONE, 2020
CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα. Biologics, including humanized CD47 monoclonal antibodies and decoy SIRPα receptors, that block the SIRPα-CD47
Teresa L Burgess, Joshua D Amason, Jeffrey S Rubin, Damien Y Duveau, Laurence Lamy, David D Roberts, Catherine L Farrell, James Inglese, Craig J Thomas, Thomas W Miller   +9 more
doaj   +1 more source

Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches

Journal of Neuroscience Research, Volume 103, Issue 5, May 2025.
ABSTRACT Alzheimer's disease (AD) is a devastating form of dementia, with the number of affected individuals rising sharply. The main hallmarks of the disease include amyloid‐beta plaque deposits and neurofibrillary tangles consisting of hyperphosphorylated tau protein, besides other pathological features that contribute to the disease's complexity ...
Sally Kelliny, Xin‐Fu Zhou, Larisa Bobrovskaya   +2 more
wiley   +1 more source

Natural pigments derived from plants and microorganisms: classification, biosynthesis, and applications

Plant Biotechnology Journal, Volume 23, Issue 2, Page 592-614, February 2025.
Summary Pigments, as coloured secondary metabolites, endow the world with a rich palette of colours. They primarily originate from plants and microorganisms and play crucial roles in their survival and adaptation processes. In this article, we categorize pigments based on their chemical structure into flavonoids, carotenoids, pyrroles, quinones ...
Qian Tang, Zhibo Li, Ningxin Chen, Xiaozhou Luo, Qiao Zhao   +4 more
wiley   +1 more source

Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice

Molecular Metabolism
Objectives: Aggregation and misfolding of amyloid beta (Aβ) and tau proteins, suggested to arise from post-translational modification processes, are thought to be the main cause of Alzheimer's disease (AD).
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Pazenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler   +15 more
doaj   +1 more source

Post‐translational modifications in the Protein Data Bank

Acta Crystallographica Section D, Volume 80, Issue 9, Page 647-660, September 2024.
This review explores the importance of post‐translational modifications (PTMs) in the Protein Data Bank and identifies examples of well modelled PTMs.Proteins frequently undergo covalent modification at the post‐translational level, which involves the covalent attachment of chemical groups onto amino acids.
Lucy C. Schofield, Jordan S. Dialpuri, Garib N. Murshudov, Jon Agirre   +3 more
wiley   +1 more source

Alzheimer's disease drug development pipeline: 2024

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 10, Issue 2, April‐June 2024.
Abstract INTRODUCTION New therapies to prevent or delay the onset of symptoms, slow progression, or improve cognitive and behavioral symptoms of Alzheimer's disease (AD) are needed. METHODS We interrogated clinicaltrials.gov including all clinical trials assessing pharmaceutical therapies for AD active in on January 1, 2024.
Jeffrey Cummings, Yadi Zhou, Garam Lee, Kate Zhong, Jorge Fonseca, Feixiong Cheng   +5 more
wiley   +1 more source

Overcoming the egress block of Plasmodium sporozoites expressing fluorescently tagged circumsporozoite protein

Molecular Microbiology, Volume 121, Issue 3, Page 565-577, March 2024.
Mosquitoes infected with Plasmodium parasites transmit malaria. The parasites grow in a cyst in the mosquito gut and leave this cyst when developed. Previously, visualizing the main surface protein of the parasite, the circumsporozoite protein (CSP), has blocked exit. We explore novel strategies to bypass the exit block and visualize CSP.
Carolina Thieleke‐Matos, Kevin Walz, Friedrich Frischknecht, Mirko Singer   +3 more
wiley   +1 more source

Cerebral Amyloid Angiopathy like pathology accompanied by intense gliosis in T2D‐induced APPxhQC mice [PDF]

Alzheimers Dement
Abstract Background Cerebral Amyloid Angiopathy (CAA), characterized by the presence of amyloid β (Aβ) deposits in cerebral blood vessels has been associated with cognitive impairment and Alzheimer’s disease (AD). Vascular risk factors, such as type 2 diabetes (T2D), are known to affect vascular pathology and CAA‐like depositions.
Babalola J, Neddens J, Leitinger G, Hutter‐Paier B, Hoefler G.   +4 more
europepmc   +2 more sources