Results 161 to 170 of about 107,521,968 (199)
Effect of peroxynitrite on glutaredoxin
Human and Experimental Toxicology, 2001 Glutaredoxin is an important enzyme in thiol homeostasis. As a thioltransferase, it reduces oxidized thiols. It also has dehydroascorbate reductase (DHAR) activity to reduce dehydroascorbate (DHA) to ascorbic acid.
G Aykaç-Toker
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Expression of Glutaredoxin-1 in Nasal Polyps and Airway Epithelial Cells
American Journal of Rhinology & Allergy, 2009Background Glutaredoxins (GRX)-1 is glutathione-dependent oxidoreductase. However, the role of these enzymes remains unknown in airway inflammatory diseases. Therefore, we aimed to establish the expression pattern of GRX-1 in the nasal polyps (NPs) and to assess the regulatory mechanisms associated with GRX-1 ...
Hyun-Jae, Woo +5 more
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Abstract 21314: Glutaredoxin-1: An Endothelial Protector in Hyperlipidemia
Circulation, 2017Background: Hypercholesterolemia (HC) dominates the risk factors for atherosclerosis. Sustained oxidative stress is a central mechanism driving endothelial dysfunction (ED) in HC. But the underlying redox mechanism remains unclear.
Jingyan Han, Huijie Fan, Naomi Hamburg
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Hypoxia-Inducible Factor 1α Stability Modified by Glutaredoxin-1 in Necrotizing Enterocolitis
Journal of Surgical Research, 2022Hypoxia-inducible factor (HIF) 1α is essential for the pathogenesis of necrotizing enterocolitis (NEC). HIF-1α is stabilized by glutaredoxin-1 (Grx1) deletion. The precise role of HIF-1α in the intestinal microcirculation in NEC is not well defined. We aimed to determine the role of HIF-1α in the regulation of the intestinal microcirculation during the
Yunfei Zhang +4 more
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Glutaredoxin-1 control on liver fibrosis in aged mice
Free Radical Biology and Medicine, 2017Objective Glutaredoxin-1 (Glrx) is a cytosolic enzyme which removes glutathione (GSH) adducts of protein thiols (S-glutathionylation), and controls protein functions including cellular signaling and gene transcription. We previously showed that Glrx knockout middle-aged mice developed liver steatosis and Glrx replenishment by viral gene transfer ...
Yuko Tsukahara +4 more
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In vivo quantitative measurement of oxidation repair of glutaredoxin‐1
Acta Ophthalmologica, 2010Abstract Purpose Quantitative determination of the impact of glutaredoxin‐1 on sensitivity to oxidative stress induced by in vivo exposure to ultraviolet radiation in the 300 nm wavelength region. Methods Altogether, 20 glutredoxin‐1 knockout mice (Grx1 ‐/‐) and 20 wild type C57BL/6, bred on the same background were in vivo exposed unilaterally to ...
PG SÖDERBERG +3 more
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Monocytic Glutaredoxin 1 Protects Mice against Obesity, Hyperglycemia and Atherosclerosis
Free Radical Biology and Medicine, 2016We previously reported that glutaredoxin 1 (Grx1) protects monocytes from metabolic-stress induced priming, dysregulation and hypersensitization to chemokines. To address the role of monocytic Grx1 in mice and in the development of atherogenesis and obesity, we transplanted bone marrow (BM) from either wild-type (WT) or Grx1-/- (Grx1Leuko -/-) donor ...
Reto Asmis +4 more
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Journal of Molecular and Cellular Cardiology, 2008
This study examined if glutaredoxin-1 (Glrx1), a redox-regulator of thioredoxin superfamily, plays any role in the redox signaling of ischemic myocardium. The hearts were subjected to 30 min of coronary occlusion followed by 24 h of reperfusion. Another group of hearts was rendered tolerant to ischemia (preconditioned, PC) by four cyclic episodes of 5 ...
Gautam, Malik +4 more
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This study examined if glutaredoxin-1 (Glrx1), a redox-regulator of thioredoxin superfamily, plays any role in the redox signaling of ischemic myocardium. The hearts were subjected to 30 min of coronary occlusion followed by 24 h of reperfusion. Another group of hearts was rendered tolerant to ischemia (preconditioned, PC) by four cyclic episodes of 5 ...
Gautam, Malik +4 more
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Glutaredoxin-1 levels in plasma can predict future events in patients with cardiovascular diseases
Free Radical Biology and Medicine, 2021Reactive oxygen species that increase during cardiovascular disease (CVD) react with protein cysteine residues to form a glutathione adduct by S-glutathionylation, which is selectively removed by glutaredoxin-1 (Glrx). We previously showed that S-glutathionylation and Glrx play important roles in mouse models of CVD, such as heart failure and ...
Yosuke Watanabe +10 more
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Exploration of glutaredoxin-1 oxidative modification in carbon nanomaterial-induced hepatotoxicity
The AnalystGraphene oxide can increase the levels of intracellular H 2 O 2 and ˙OH, and cause the irreversible oxidative modification. This leads to the activation of the JNK/p38 signaling pathway and promote hepatocyte apoptosis.
Wen Gao +7 more
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