Results 141 to 150 of about 9,840 (178)
Study of the involvement of glutaredoxin 1 in copper homeostasis in neuroblastoma cells
, 2013 Copper (Cu) is a redox transition metal existing in two ionic forms, Cu+ and Cu++. In biological systems the electrochemical properties of copper ions make it an important cofactor for many enzymes that catalyze a wide range of biochemical processes such as oxidative phosphorylation, antioxidant defense, catecholamine synthesis, iron homeostasis and ...
DE BENEDETTO, MARIA LISA
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Expression of Glutaredoxin-1 in Nasal Polyps and Airway Epithelial Cells
American Journal of Rhinology & Allergy, 2009Background Glutaredoxins (GRX)-1 is glutathione-dependent oxidoreductase. However, the role of these enzymes remains unknown in airway inflammatory diseases. Therefore, we aimed to establish the expression pattern of GRX-1 in the nasal polyps (NPs) and to assess the regulatory mechanisms associated with GRX-1 ...
Hyun-Jae, Woo +5 more
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Glutaredoxin-1 control on liver fibrosis in aged mice
Free Radical Biology and Medicine, 2017Objective Glutaredoxin-1 (Glrx) is a cytosolic enzyme which removes glutathione (GSH) adducts of protein thiols (S-glutathionylation), and controls protein functions including cellular signaling and gene transcription. We previously showed that Glrx knockout middle-aged mice developed liver steatosis and Glrx replenishment by viral gene transfer ...
Yuko Tsukahara +4 more
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In vivo quantitative measurement of oxidation repair of glutaredoxin‐1
Acta Ophthalmologica, 2010Abstract Purpose Quantitative determination of the impact of glutaredoxin‐1 on sensitivity to oxidative stress induced by in vivo exposure to ultraviolet radiation in the 300 nm wavelength region. Methods Altogether, 20 glutredoxin‐1 knockout mice (Grx1 ‐/‐) and 20 wild type C57BL/6, bred on the same background were in vivo exposed unilaterally to ...
PG SÖDERBERG +3 more
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Hypoxia-Inducible Factor 1α Stability Modified by Glutaredoxin-1 in Necrotizing Enterocolitis
Journal of Surgical Research, 2022Hypoxia-inducible factor (HIF) 1α is essential for the pathogenesis of necrotizing enterocolitis (NEC). HIF-1α is stabilized by glutaredoxin-1 (Grx1) deletion. The precise role of HIF-1α in the intestinal microcirculation in NEC is not well defined. We aimed to determine the role of HIF-1α in the regulation of the intestinal microcirculation during the
Yunfei Zhang +4 more
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Fish and Shellfish Immunology, 2012 Glutaredoxin (abbreviated as Grx) is an important ubiquitous disulfide reductase, which can protect organisms against oxidative stresses. In the present study, a monothiol glutaredoxin gene (named as VpGrx1) and a dithiol glutaredoxin gene (named as ...
Changkao Mu, Qing Wang, Chunlin Wang
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Abstract 21314: Glutaredoxin-1: An Endothelial Protector in Hyperlipidemia
Circulation, 2017Background: Hypercholesterolemia (HC) dominates the risk factors for atherosclerosis. Sustained oxidative stress is a central mechanism driving endothelial dysfunction (ED) in HC. But the underlying redox mechanism remains unclear.
Jingyan Han, Huijie Fan, Naomi Hamburg
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Journal of Molecular and Cellular Cardiology, 2008
This study examined if glutaredoxin-1 (Glrx1), a redox-regulator of thioredoxin superfamily, plays any role in the redox signaling of ischemic myocardium. The hearts were subjected to 30 min of coronary occlusion followed by 24 h of reperfusion. Another group of hearts was rendered tolerant to ischemia (preconditioned, PC) by four cyclic episodes of 5 ...
Gautam, Malik +4 more
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This study examined if glutaredoxin-1 (Glrx1), a redox-regulator of thioredoxin superfamily, plays any role in the redox signaling of ischemic myocardium. The hearts were subjected to 30 min of coronary occlusion followed by 24 h of reperfusion. Another group of hearts was rendered tolerant to ischemia (preconditioned, PC) by four cyclic episodes of 5 ...
Gautam, Malik +4 more
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Exploration of glutaredoxin-1 oxidative modification in carbon nanomaterial-induced hepatotoxicity
The AnalystGraphene oxide can increase the levels of intracellular H2O2 and ˙OH, and cause the irreversible oxidative modification. This leads to the activation of the JNK/p38 signaling pathway and promote hepatocyte apoptosis.
Wen Gao +7 more
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The role of glutaredoxin-1 in pulmonary inflammation induced by diesel exhaust particles
European Respiratory Journal, 2013Rationale: Inhalation of diesel exhaust particles (DEP) is associated with an oxidative and inflammatory response in the lung (Provoost et al., J Allergy Clin Immunol., 2012, 129: 483-491). Glutaredoxin-1 (GRX1) is a cytosolic enzyme that can regulate redox-dependent signalling cascades and pro-inflammatory ...
Sharen Provoost +6 more
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