Results 121 to 130 of about 107,521,968 (199)

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. [PDF]

Sci Adv, 2021
Xi Y, Li Y, Xu P, Li S, Liu Z, Tung HC, Cai X, Wang J, Huang H, Wang M, Xu M, Ren S, Li S, Zhang M, Lee YJ, Huang L, Yang D, He J, Huang Z, Xie W.   +19 more
europepmc   +1 more source

Preparation, Characterization, and Complete Heteronuclear NMR Resonance Assignments of the Glutaredoxin (C14S)−Ribonucleotide Reductase B1 737−761 (C754S) Mixed Disulfide^†

, 2016
The first committed step in de novo DNA biosynthesis involves the conversion of ribonucleotides to the corresponding deoxyribonucleotides catalyzed by the enzyme ribonucleotide reductase.
John H. Bushweller (1272324), Marcelo J. Berardi (2949942), Cynthia L. Pendred (2949939)   +2 more
core   +1 more source

Characterization of a major polysaccharide from Sagittaria trifolia L. and its protective effects on cataract

Journal of Agriculture and Food Research
The objective of this study was to isolate and characterize polysaccharides from Sagittaria trifolia L. tubers and to investigate their potential protective effects against cataract.
Jian-bin Sun, Man-yu Zhou, Bi-sui Yang, Xiao-li Mei, Liang-ke Zhang, Wei-zao Luo, Yan Liao   +6 more
doaj   +1 more source

Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity

, 2007
Oxidative stress, excitotoxicity and mitochondrial dysfunction play synergistic roles in neurodegeneration. Maintenance of thiol homeostasis is important for normal mitochondrial function and dysregulation of protein thiol homeostasis by oxidative stress
Kenchappa, Rajappa S., Diwakar, Latha, Annepu, Jayasree, Ravindranath, Vijayalakshmi   +3 more
core   +1 more source

Glutaredoxin-1 [PDF]

, 2020
openaire   +1 more source

GLUTATHIONE AND GLUTAREDOXIN IN ROSCOVITINE-MEDIATED INHIBITION OF BREAST CANCER CELL PROLIFERATION

, 2017
Background: Breast tumors are number one cause of cancer morbidity and mortality among women around the world, and Russia is not an exception. Many proteins that control proliferation of immortalized cells are redox-regulated, which is essential for ...
E. V. Rudikov, E. A. Stepovaya, O. L. Nosareva, E. V. Shakhristova, V. V. Novitsky   +4 more
core   +1 more source

Redox homeostasis and inflammation in fibroblasts of patients with Friedreich Ataxia: a possible cross talk

Frontiers in Molecular Neuroscience
Redox homeostasis is impaired in Friedreich’s Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial protein frataxin.
Andrea Quatrana, Sara Petrillo, Caterina Torda, Eleonora De Santis, Enrico Bertini, Fiorella Piemonte   +5 more
doaj   +1 more source

Structural and dynamic analysis of human glutaredoxin 3

Human glutaredoxin (Grx3) is an essential protein associated with biological functions including embryonic development and immune response, and is involved in human disease such as lung, colon cancer and cardiovascular disorder.
Andrésen, Cecilia,, Sunnerhagen, Maria,, Lundström, Patrik,   +2 more
core  

Prediction of thioredoxin and glutaredoxin target proteins by identifying reversibly oxidized cysteinyl residues.

, 2010
Lee H-M, Dietz K-J, Hofestädt R. Prediction of thioredoxin and glutaredoxin target proteins by identifying reversibly oxidized cysteinyl residues. Journal of Integrative Bioinformatics (Special Issue).
Dietz, Karl-Josef, Hofestädt, Ralf, Lee Hang-mao, Ralf Hofestädt, Hofestädt Ralf, Karl Josef Dietz, Lee, Hang-Mao, Dietz Karl Josef, Hang-mao Lee   +8 more
core   +1 more source

Mechanistic insight provided by glutaredoxin within a fusion to redox-sensitive yellow fluorescent protein

, 2006
Udgivelsesdato: 2006-Feb-21Redox-sensitive yellow fluorescent protein (rxYFP) contains a dithiol disulfide pair that is thermodynamically suitable for monitoring intracellular glutathione redox potential.
Winther, Jakob R, Østergaard, Henrik, Björnberg, Olof   +2 more
core   +1 more source