Results 101 to 110 of about 107,521,968 (199)

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Dynamics of the glutathione/glutaredoxin system. [PDF]

, 2014
M. Sc. University of KwaZulu-Natal, Pietermaritzburg 2014.The glutathione/glutaredoxin system is made up of glutaredoxins, glutathione (GSH) and glutathione reductase (GLR).
Mashamaite, Lefentse Nelly.
core   +1 more source

Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems

, 2003
Our studies in yeast show that there is an essential requirement for either an active thioredoxin or an active glutathione (GSH)-glutaredoxin system for cell viability.
Eleanor W Trotter, Grant, Chris M., Chris M Grant, Trotter, Eleanor W.   +3 more
core   +1 more source

Double Alkynylation of Quinoline-5,8-diones and their In-silico and Antimicrobial Studies

Journal of Applied Sciences and Environmental Management, 2018
A double alkynylation of quinoline-5,8-dione to furnished bis-alkynylquinoline-5,8-dione in good yields and their in silico and antimicrobial studies is described.
MA Ezeokonkwo, JA Ezugwu, SN Okafor, EA Onoabedje, EU Godwin-Nwakwasi, FN Ibeanu   +5 more
doaj   +1 more source

Utilizing redox-sensitive GFP fusions to detect in vivo redox changes in a genetically engineered prokaryote

Redox Biology, 2019
Understanding the in vivo redox biology of cells is a complex albeit important biological problem. Studying redox processes within living cells without physical disruption or chemical modifications is essential in determining the native redox states of ...
Wilhad Hans Reuter, Thorsten Masuch, Na Ke, Marine Lenon, Meytal Radzinski, Vu Van Loi, Guoping Ren, Paul Riggs, Haike Antelmann, Dana Reichmann, Lars I. Leichert, Mehmet Berkmen   +11 more
doaj   +1 more source

Engineering functional artificial hybrid proteins between poplar peroxiredoxin II and glutaredoxin or thioredoxin

, 2006
International audienceThe existence of natural peroxiredoxin–glutaredoxin hybrid enzymes in several bacteria is in line with previous findings indicating that poplar peroxiredoxin II can use glutaredoxin as an electron donor.
Gans, Pierre, Rouhier, Nicolas,, Wingsle, Gunnar, Jacquot, Jean-Pierre, Rouhier, Nicolas, Gama, Filipe, Gelhaye, Éric, Rouhier, N, Gama, F, Jacquot, J-P, Swedish University of Agricultural Sciences., Wingsle, Gunnar,, Gelhaye, E, Gans, P   +13 more
core   +1 more source

Utility of Synechocystis sp. PCC glutaredoxin A as a platform to study high-resolution mutagenesis of proteins. [PDF]

, 2013
Glutaredoxin from the cyanobacterium Synechocystis sp. PCC 6803 is a small protein, containing only 88 amino acids, that participates in a large number of redox reactions, serving both as an electron donor for enzyme-catalyzed reductions and as a ...
David B Knaff, Roger Bryan Sutton, Knaff, David B., Roger B. Sutton, David B. Knaff, Sutton, Roger B.   +5 more
core   +1 more source

Iron-sulfur glutaredoxin 2 protects oligodendrocytes against damage induced by nitric oxide release from activated microglia

, 2017
Demyelinated brain lesions, a hallmark of autoimmune neuroinflammatory diseases like multiple sclerosis, result from oligodendroglial cell damage. Activated microglia are considered a major source of nitric oxide and subsequent peroxynitrite-mediated ...
Hildebrandt, T., Arne Holmgren, Lawrence Steinman, Klaudia Lepka, Natalia Rios, Thomas Hildebrandt, Volbracht, K., Berndt, C., Reiner Schneider, Lillig, C., Steinman, L., Ingwersen, J., Rafael Radi, Hartung, H., Orhan Aktas, Katrin Volbracht, Eckhard Bill, Schneider, R., Lepka, K., Holmgren, A., Bill, E., Prozorovski, T., Jack van Horssen, Carsten Berndt, Rios, N., van Horssen, J., Christopher Horst Lillig, Aktas, O., Timur Prozorovski, Jens Ingwersen, Hans-Peter Hartung, Radi, R., Prozorovski, T, Volbracht, K, Schneider, R, van, Horssen J, Rios, N, Hildebrandt, T, Bill, E, Lepka, K, Ingwersen, J, Lillig, CH   +41 more
core   +1 more source

Regulatation of hepatic lipid metabolism by glutaredoxin‐1 and protein glutathione‐adducts

The FASEB Journal, 2015
Objective Oxidants can contribute to cellular signaling via glutathione‐(GSH) adducts, which are reversible post‐translational modifications of proteins that alter their function. Glutaredoxin‐1 (Glrx) is an enzyme that specifically removes these GSH‐adducts and modulates enzyme activity ...
Di Shao, Jingyan Han, Xiuyun Hou, Jessica Fry, Jessica Behring, Chunxiang Yao, Xiang Weng, David Pimentel, Michelle Long, Hemant Roy, Francesca Seta, Richard Cohen, Reiko Matsui, Markus Bachschmid   +13 more
openaire   +1 more source