Results 81 to 90 of about 9,840 (178)

Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2

Antioxidants, 2019
Our group recently published a study demonstrating that deleting the gene encoding the matrix thiol oxidoreductase, glutaredoxin-2 (GRX2), alters the bioenergetics of mitochondria isolated from male C57BL/6N mice.
Sarah Mallay, Robert Gill, Adrian Young, Ryan J. Mailloux   +3 more
doaj   +1 more source

Genetic dissection and transcriptomic analysis of a novel high‐tillering phenotype in rice derived from weedy rice (Hapcheonaengmi3) and Tongil‐type Rice (Milyang23)

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Rice (Oryza sativa L.) tillering is a critical determinant of grain yield, yet the genetic mechanisms underlying non‐productive tillers remain poorly understood. Here, we report a novel high‐tillering (HT) phenotype derived from a cross between the elite cultivar Milyang23 and weedy rice Hapcheonaengmi3. The HT phenotype was absent in parental
Kyu‐Chan Shim, Donghyun Jeon, Yun‐A Jeon, Cheryl Adeva, Hyun‐Sook Lee, Ju‐Won Kang, Sa‐Eun Park, Sang‐Nag Ahn, Inkyu Park   +8 more
wiley   +1 more source

Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis

, 2018
Glutaredoxin-1 (Grxl) catalyzes deglutathionylation with glutathione as a cofactor. Accumulating evidence indicates important roles for Grxl and S-glutathionylation in the aging process; however, further exploration of Grxl-regulated cellular processes ...
Liu, Yan, Wang, Qjngtao, Yan Liu, Hu, Yadong, Meiqi Yi, Yadong Hu, Yang, Fan, Qingtao Wang, Yi, Meiqi, Haiteng Deng, Deng, Haiteng, Fan Yang   +11 more
core   +1 more source

Redox regulation of ischemic limb neovascularization – What we have learned from animal studies

Redox Biology, 2017
Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to ...
Reiko Matsui, Yosuke Watanabe, Colin E. Murdoch   +2 more
doaj   +1 more source

Genetic identification and characterization of novel loci for flag leaf morphology traits in Chinese endemic wheat

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Flag leaf morphology (FLM) is a critical determinant of wheat (Triticum aestivum L.) photosynthetic efficiency and grain yield. Chinese endemic wheat, a unique genetic reservoir formed by long‐term adaptation to diverse and heterogeneous environments in China, harbors abundant, untapped allelic variation for traits related to environmental ...
Md Nahibuzzaman Lohani, Longxing Su, Lu Lu, Li Yin, Yanlin Liu, Qiang Xu, Yunfeng Jiang, Qiantao Jiang, Guoyue Chen, Yuming Wei, Chunji Liu, Quan Xie, Jian Ma   +12 more
wiley   +1 more source

Cytokinin downregulates Photosystem II photochemistry during prolonged darkness in a phytochrome B‐dependent manner

New Phytologist, Volume 250, Issue 6, Page 3846-3866, June 2026.
Cytokinin–phyB signaling modulates PSII photochemistry during prolonged darkness. Summary Cytokinins (CKs) delay dark‐induced senescence, but how they tune photosynthetic function in darkness remains unclear. We investigated the effects of classical aromatic CK benzylaminopurine and CK‐derived compound 1‐(2‐methoxyethyl)‐3‐(1,2,3‐thiadiazol‐5‐yl)urea ...
Veronika Kábrtová, Zuzana Kučerová, Ivo Chamrád, René Lenobel, Pavel Roudnický, Jan Skalák, Martin Hudeček, Filip Zavadil Kokáš, Marek Rác, Tereza Vánská, Jaroslav Nisler, Jan Hejátko, Miroslav Strnad, Martina Špundová, Ondřej Plíhal   +14 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, Volume 600, Issue 10, Page 1420-1443, May 2026.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, Volume 19, Issue 5, May 2026.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation.

, 2011
Protein S-glutathionylation (PSSG), a reversible posttranslational modification of reactive cysteines, recently emerged as a regulatory mechanism that affects diverse cell-signaling cascades.
Ho, Y.S., Kuipers, I., Ye-Shih Ho, Janssen-Heininger, Y.M.W., Aesif, S.W., Amy S. Guala, Scott W. Aesif, Reiss, J.N., Ine Kuipers, Yvonne M. W. Janssen-Heininger, Vikas Anathy, Anathy, V., Guala, A.S., Jessica N. Reiss   +13 more
core   +1 more source