Results 71 to 80 of about 9,840 (178)

In vitro and in silico assessment of new beta amino ketones with antiplasmodial activity

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: Based on the current need for new drugs against malaria, our study evaluated eight beta amino ketones in silico and in vitro for potential antimalarial activity.
Gabriela Camila Krombauer, Karla de Sena Guedes, Felipe Fingir Banfi, Renata Rachide Nunes, Amanda Luisa da Fonseca, Ezequias Pessoa de Siqueira, Jéssica Côrrea Bezerra Bellei, Kézia Katiani Gorza Scopel, Fernando de Pilla Varotti, Bruno Antônio Marinho Sanchez   +9 more
doaj   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Lidwina Hasberg, Viktoria Katharina Lauterbach, Torsten Ochsenreiter, Jan Riemer   +3 more
wiley   +1 more source

Deciphering Cold Stress Resilience: Multiomics Insights in Contrasting Wheat Genotypes From the Western Himalayas

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4577-4598, July 2026.
ABSTRACT Cold stress threatens wheat productivity, particularly in regions with extreme climatic conditions. To elucidate the molecular mechanisms underlying wheat's response to cold stress, we performed a multiomics analysis integrating lipidomics, transcriptomics, proteomics and metabolomics.
Sofora Jan, Farkhandah Jan, Mukesh Rathore, Yogita Singh, Prexha Kapoor, Palak Chaturvedi, Arindam Ghatak, Palakurthi Ramesh, Upendra Kumar, Manoj Prasad, Sundeep Kumar, Sachin Rustgi, Wolfram Weckwerth, Sanjay Kalia, Rajeev Kumar Varshney, Reyazul Rouf Mir   +15 more
wiley   +1 more source

Monothiol Glutaredoxin-1 Is an Essential Iron-Sulfur Protein in the Mitochondrion of African Trypanosomes [PDF]

Journal of Biological Chemistry, 2008
African trypanosomes encode three monothiol glutaredoxins (1-C-Grx). 1-C-Grx1 occurs exclusively in the mitochondrion, and 1-C-Grx2 and -3 are predicted to be mitochondrial and cytosolic proteins, respectively. All three 1-C-Grx are expressed in both the mammalian bloodstream and the insect procyclic form of Trypanosoma brucei, with the highest levels ...
Marcelo A, Comini, Jochen, Rettig, Natalie, Dirdjaja, Eva-Maria, Hanschmann, Carsten, Berndt, R Luise, Krauth-Siegel   +5 more
openaire   +2 more sources

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Under the Cover of Darkness: A Transcriptomic Exploration of Clubroot During the Night

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Plasmodiophora brassicae (Phytomyxea, Rhizaria) is the etiological agent of clubroot disease, one of the most important diseases of Brassicaceae crops. Alteration of metabolism and hormone homeostasis leads to the formation of tumor‐like galls in the roots of affected plants.
Andrea Garvetto, Susann Auer, Freia Benade, Michaela Hittorf, Jutta Ludwig‐Müller, Sigrid Neuhauser   +5 more
wiley   +1 more source

Sketching microprotein portraits

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The illustrations of intricate molecular machineries inside cells created by David Goodsell continue to inspire the scientific community. Here, we aim to extend his artworks to include microproteins, a newly recognized class of small proteins with less than 100 amino acids, encoded by small open reading frames.
Gabriel Diaz, Philippe Valenti, Marc Gueroult, Simon Marques‐Prieto, Kenza Benachenhou, Jennifer Zanet, Matthieu Chavent   +6 more
wiley   +1 more source

The Protective Role of Glutaredoxin‐1 in Endothelial Barrier Regulation and Atherosclerosis

The FASEB Journal, 2015
Vascular oxidative stress is widely invoked as an important pathogenic mechanism for atherosclerosis (AS). Protein S‐glutathionylation (P‐SSG), the prevalent post‐translational oxidative modification, is emerging as a critical redox signaling mechanism in cardiovascular diseases. However, its role in AS is not clear yet.
Jingyan Han, Richard Cohen, Reiko Matsui
openaire   +1 more source

Glutaredoxin-1 Is up-regulated in preeclampsia and increases soluble Flt-1 expression

, 2015
Introduction: Preeclampsia is a vascular disorder in pregnancyand is biochemical characterization by high soluble Flt-1 and lowplacenta growth factor as well as an imbalance in redox homeostasis.During conditions of high oxidative stress, cysteine ...
Georgiadou, Athina, Bartkeviciute, Milda, Murdoch, Colin E.; id_orcid, Broadway-Stringer, Sophie, Ahmed, Asif   +4 more
core   +1 more source