Results 61 to 70 of about 9,840 (178)

Irreversible Inactivation of Glutaredoxins 1 and 2 by Peroxynitrite

Bulletin of the Korean Chemical Society, 2007
who showedthat rat liver cytosolic fractions lose glutaredoxin activitywhen treated with peroxynitrite. Considering the potentialrole of S-glutathionylation in signaling, inactivation ofglutaredoxins by reactive nitrogen species deserves detailedstudy.We report here that peroxynitrite among the nitric oxidecongeners is a very effective inactivator of ...
openaire   +2 more sources

In situ detection of S-glutathionylated proteins following glutaredoxin-1 catalyzed cysteine derivatization

, 2006
S-glutathionylation is rapidly emerging as an important post-translational modification, responsible for transducing oxidant signals. However, few approaches are available that allow visualization of glutathione mixed disulfides in intact cells.
van der Vliet, A., Wouters, E.F., Reynaert, N.L., Ckless, K., Guala, A.S., Janssen-Heininger, Y.M.   +5 more
core   +1 more source

Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

eLife, 2020
Antioxidant systems, such as the thioredoxin-1 (Trx1) pathway, ensure cellular redox homeostasis. However, how such systems regulate development and function of myeloid cells is barely understood.
Jonathan Muri, Helen Thut, Qian Feng, Manfred Kopf   +3 more
doaj   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source

The Thioltransferase (Glutaredoxin) 1 Gene of Fission Yeast Is Regulated by Atf1 and Pap1

Molecules and Cells, 2003
We previously isolated a gene encoding thioltransferase (TTase1) from the fission yeast Schizosaccharomyces pombe. Using a TTase-lacZ fusion plasmid, carrying a 666 bp region upstream of the translation initiation point, we found that expression of TTase1 was enhanced by metal ions, diamide and NO-generating S-nitroso-N-acetylpenicillamine (SNAP).
Chang-Jin, Lim, Young-Wook, Cho, Sung-Min, Hong, Hye-Won, Lim, Eun-Hee, Park   +4 more
openaire   +2 more sources

The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function

Experimental Eye Research, 2023
Glutaredoxins (Grx1 and Grx2) are thiol-repair antioxidant enzymes that play vital roles in cellular redox homeostasis and various cellular processes. This study aims to evaluate the functions of the glutaredoxin (Grx) system, including glutaredoxin 1 (Grx1) and glutaredoxin 2 (Grx2), using Grx1/Grx2 double knockout (DKO) mice as a model.
Jinmin, Zhang, Yu, Yu, Terry, Dang, Kevin, Lal, Hongli, Wu   +4 more
openaire   +2 more sources

Systemic remodeling of the redox regulatory network due to RNAi perturbations of glutaredoxin 1, thioredoxin 1, and glucose-6-phosphate dehydrogenase

, 2011
Background Cellular clearance of reactive oxygen species is dependent on a network of tightly coupled redox enzymes; this network rapidly adapts to oxidative conditions such as aging, viral entry, or inflammation.
Shukla, Shreya, Melissa L Kemp, Kippner, Linda E, Linda E Kippner, Finn, Nnenna A, Shreya Shukla, Nnenna A Finn, Kemp, Melissa L   +7 more
core   +2 more sources

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, Volume 49, Issue 8, Page 5849-5865, August 2026.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

Involvement of glutaredoxin-1 and thioredoxin-1 in β-amyloid toxicity and Alzheimer's disease [PDF]

Cell Death & Differentiation, 2005
Strong evidence indicates oxidative stress in the pathogenesis of Alzheimer's disease (AD). Amyloid beta (Abeta) has been implicated in both oxidative stress mechanisms and in neuronal apoptosis. Glutaredoxin-1 (GRX1) and thioredoxin-1 (TRX1) are antioxidants that can inhibit apoptosis signal-regulating kinase (ASK1).
S, Akterin, R F, Cowburn, A, Miranda-Vizuete, A, Jiménez, N, Bogdanovic, B, Winblad, A, Cedazo-Minguez   +6 more
openaire   +2 more sources

Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice

Redox Biology, 2016
Selenium participates in the antioxidant defense mainly through a class of selenoproteins, including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea.
Ruixia Dong, Dongxu Wang, Xiaoxiao Wang, Ke Zhang, Pingping Chen, Chung S. Yang, Jinsong Zhang   +6 more
doaj   +1 more source