Results 41 to 50 of about 9,840 (178)

Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization. [PDF]

Proc Natl Acad Sci U S A, 2016
Reactive oxygen species (ROS) are increased in ischemic tissues and necessary for revascularization; however, the mechanism remains unclear. Exposure of cysteine residues to ROS in the presence of glutathione (GSH) generates GSH-protein adducts that are ...
Watanabe Y, Murdoch CE, Sano S, Ido Y, Bachschmid MM, Cohen RA, Matsui R.   +6 more
europepmc   +3 more sources

Inhibition of myeloid HDAC2 upregulates glutaredoxin 1 expression, improves protein thiol redox state and protects against high-calorie diet-induced monocyte dysfunction and atherosclerosis

, 2021
Background and aims: The thiol transferase glutaredoxin 1 controls redox signaling and cellular functions by regulating the S-glutathionylation status of critical protein thiols.
Wang, Luxi, Ahn, Yong Joo, Asmis, Reto
core   +1 more source

Pramipexole enhances levodopa's therapeutic efficacy in Parkinson's disease: Role of glutaredoxin-1 (GRX1), peroxiredoxin3 (PRX3), thioredoxin (TRX), 8-hydroxy-2 -deoxyguanosine (8-OHDG), and neurosteroid dehydroepiandrosterone sulfate (DHEA-S) [PDF]

Journal of Medical Biochemistry
Background: Parkinson's disease (PD) is characterised by progressive neurodegeneration and dopamine deficiency. Levodopa remains a cornerstone treatment, but its longterm use is associated with motor complications and reduced efficacy.
Shu Yu, Qian Jinjun
doaj   +1 more source

Lack of the antioxidant glutathione peroxidase-1 does not increase atherosclerosis in C57BL/J6 mice fed a high-fat diet

Journal of Lipid Research, 2006
Oxidative stress is thought to contribute to the initiation and progression of atherosclerosis. As glutathione peroxidase-1 (Gpx1) is an antioxidant enzyme that detoxifies lipid hydroperoxides, we tested the impact of Gpx1 deficiency on atherosclerotic ...
Judy B. de Haan, Paul K. Witting, Nada Stefanovic, Josefa Pete, Michael Daskalakis, Ismail Kola, Roland Stocker, Joseph J. Smolich   +7 more
doaj   +1 more source

Evidence for the dimerization-mediated catalysis of methionine sulfoxide reductase A from Clostridium oremlandii. [PDF]

PLoS ONE, 2015
Clostridium oremlandii MsrA (CoMsrA) is a natively selenocysteine-containing methionine-S-sulfoxide reductase and classified into a 1-Cys type MsrA. CoMsrA exists as a monomer in solution.
Eun Hye Lee, Kitaik Lee, Geun-Hee Kwak, Yeon Seung Park, Kong-Joo Lee, Kwang Yeon Hwang, Hwa-Young Kim   +6 more
doaj   +1 more source

Atomic Sulfur: An Element for Adaptation to an Oxidative Environment

Molecules, 2017
During the period of rising oxygen concentration in the Earth’s atmosphere (Figure 1), sulfur atoms were incorporated into proteins as redox-active cysteine residues [1] and antioxidant molecules such as thioredoxin, glutathione, and glutaredoxin ...
Noryuki Nagahara, Maria Wróbel
doaj   +1 more source

Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Redox Biology, 2017
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for ...
Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho   +6 more
doaj   +1 more source

Glutaredoxin-1 overexpression enhances neovascularization and diminishes ventricular remodeling in chronic myocardial infarction. [PDF]

PLoS ONE, 2012
Oxidative stress plays a critical role in the pathophysiology of cardiac failure, including the modulation of neovascularization following myocardial infarction (MI).
Ram Sudheer Adluri, Mahesh Thirunavukkarasu, Lijun Zhan, Nageswara Rao Dunna, Yuzo Akita, Vaithinathan Selvaraju, Hajime Otani, Juan A Sanchez, Ye-Shih Ho, Nilanjana Maulik   +9 more
doaj   +1 more source

Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling

Antioxidants, 2023
This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was designed to collect review articles and original research studies focused on advancing the current understanding of the roles of the GSH/Grx system in cellular homeostasis
Yuh-Cherng Chai, John J. Mieyal
doaj   +1 more source

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses.

, 2019
Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance.
Helen Thut, Krüger, Caroline C., Thut, H., Krueger, Caroline C., Heer, S., Martin F. Bachmann, Bornkamm, G.W., Muri, J., Kopf, Manfred, Georg W. Bornkamm, Thut, Helen, Kopf, M., Jonathan Muri, Sebastian Heer, Caroline C. Krueger, Bachmann, Martin F., Muri, Jonathan, Bornkamm, Georg W., Bachmann, M.F., Bornkamm, Georg W, Manfred Kopf, Heer, Sebastian, Krueger, C.C.   +22 more
core   +1 more source