Results 21 to 30 of about 9,840 (178)

Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1. [PDF]

J Enzyme Inhib Med Chem, 2013
Glutaredoxins (GRX) are involved in the regulation of thiol redox state. GRX-1 is a cytosolic enzyme responsible for the catalysis of deglutathionylation of proteins. To date, very few inhibitors of GRX-1 have been reported.The objective of this paper is to report 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethyl-sulfanylthiocarbonylamino ...
Sadhu SS, Callegari E, Zhao Y, Guan X, Seefeldt T.   +4 more
europepmc   +4 more sources

Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. [PDF]

Antioxid Redox Signal, 2020
Significance: Over the past several years, oxidative post-translational modifications of protein cysteines have been recognized for their critical roles in physiology and pathophysiology.
Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM.   +7 more
europepmc   +4 more sources

Making HEDS or tails of glutaredoxin catalysis: Direct reduction of bis(2-hydroxyethyl) disulfide as a non-glutathione disulfide substrate [PDF]

Redox Biology
The bis(2-hydroxyethyl) disulfide (HEDS) steady-state assay is the most commonly used assay to measure the activity and kinetic parameters of glutaredoxins.
Lukas Lang, Cedric Diaz, Erik Matonia, Marcel Deponte   +3 more
doaj   +2 more sources

Glutaredoxin-1 Mediates NADPH-Dependent Stimulation of Calcium-Dependent Insulin Secretion [PDF]

Molecular Endocrinology, 2009
Nicotinamide adenine dinucleotide phosphate (NADPH) enhances Ca(2+)-induced exocytosis in pancreatic beta-cells, an effect suggested to involve the cytosolic redox protein glutaredoxin-1 (GRX-1). We here detail the role of GRX-1 in NADPH-stimulated beta-cell exocytosis and glucose-stimulated insulin secretion.
Thomas M, Reinbothe, Rosita, Ivarsson, Dai-Qing, Li, Omid, Niazi, Xingjun, Jing, Enming, Zhang, Lena, Stenson, Ulrika, Bryborn, Erik, Renström   +8 more
core   +4 more sources

Knockdown of cytosolic glutaredoxin 1 leads to loss of mitochondrial membrane potential: implication in neurodegenerative diseases. [PDF]

PLoS ONE, 2008
Mitochondrial dysfunction including that caused by oxidative stress has been implicated in the pathogenesis of neurodegenerative diseases. Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein ...
Uzma Saeed, Lalitha Durgadoss, R Khader Valli, Dinesh C Joshi, Preeti G Joshi, Vijayalakshmi Ravindranath   +5 more
doaj   +3 more sources

The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region [PDF]

Scientific Reports, 2018
Glutaredoxins (Grx) are small proteins conserved throughout all the kingdoms of life that are engaged in a wide variety of biological processes and share a common thioredoxin-fold.
Mattia Sturlese, Bruno Manta, Andrea Bertarello, Mariana Bonilla, Moreno Lelli, Barbara Zambelli, Karin Grunberg, Stefano Mammi, Marcelo A. Comini, Massimo Bellanda   +9 more
doaj   +2 more sources

Cigarette Smoke Targets Glutaredoxin 1, Increasing S-Glutathionylation and Epithelial Cell Death [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2011
Abstract It is established that cigarette smoke (CS) causes irreversible oxidations in lung epithelial cells, and can lead to their death. However, its impact on reversible and physiologically relevant redox-dependent protein modifications remains to be investigated.
Kuipers, I., Guala, A.S., Aesif, S.W., Konings, G.F.J., Bouwman, F.G., Mariman, E.C., Wouters, E.F.M., Janssen Heininger, Y.M., Reynaert, N.L.   +8 more
openaire   +3 more sources

Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. [PDF]

Antioxid Redox Signal, 2017
Aims: Nonalcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity, and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolism cause NAFL.
Shao D, Han J, Hou X, Fry J, Behring JB, Seta F, Long MT, Roy HK, Cohen RA, Matsui R, Bachschmid MM.   +10 more
europepmc   +4 more sources

Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. [PDF]

Antioxid Redox Signal, 2016
Aims: Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts ...
Gorelenkova Miller O, Behring JB, Siedlak SL, Jiang S, Matsui R, Bachschmid MM, Zhu X, Mieyal JJ.   +7 more
europepmc   +4 more sources

Increased glutaredoxin-1 and decreased protein S-glutathionylation in sputum of asthmatics. [PDF]

Eur Respir J, 2013
To the Editor: Total reduced glutathione (GSH), the main pulmonary antioxidant, is increased in asthma patients and, in some studies, increased amounts of oxidised glutathione (GSSG) were also found. In addition, enzymes that regulate the GSH redox cycle are altered in asthmatics (reviewed in [1]).
Kuipers I, Louis R, Manise M, Dentener MA, Irvin CG, Janssen-Heininger YM, Brightling CE, Wouters EF, Reynaert NL.   +8 more
europepmc   +5 more sources