Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1 [PDF]
Molecules, 2023 Trypanosoma brucei is a species of kinetoplastid causing sleeping sickness in humans and nagana in cows and horses. One of the peculiarities of this species of parasites is represented by their redox metabolism. One of the proteins involved in this redox
Annagiulia Favaro +5 more
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Sputum Glutaredoxin 1 and Protein S-Glutathionylation in COPD [PDF]
AntioxidantsAlterations in glutathione and its metabolism contribute to oxidative stress in COPD, but the role of S-glutathionylation (PSSG) and its major regulator glutaredoxin 1 (Grx1) remains unclear.
Ine Kuipers +7 more
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Glutaredoxin 1 regulates macrophage polarization through mediating glutathionylation of STAT1 [PDF]
Thoracic Cancer, 2020 Background Macrophage polarization affects tumor growth, metabolism, and many other tumor processes. M1 macrophages can promote antitumor immunity response.
Lijuan Guo +13 more
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Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis [PDF]
Antioxidants, 2022 Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging.
Yuko Tsukahara +6 more
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Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites [PDF]
Journal of Pharmaceutical Analysis, 2023 Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF).
Ying Xu +12 more
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Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway [PDF]
Clinical and Translational Medicine, 2023 Background Lymphangioleiomyomatosis (LAM) is a female‐predominant interstitial lung disease, characterized by progressive cyst formation and respiratory failure.
Ya Feng +10 more
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Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner [PDF]
Nature Communications, 2022 High-calorie diet promotes thiol oxidative stress and the reprogramming of blood monocytes, giving rise to obesogenic and proatherogenic macrophages.
Yong Joo Ahn +5 more
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Glutaredoxin 1 Deficiency Leads to Microneme Protein-Mediated Growth Defects in Neospora caninum [PDF]
Frontiers in Microbiology, 2020 Neospora caninum is an obligate intracellular protozoan parasite that infects a wide range of mammalian species and causes spontaneous abortion in cattle. N. caninum is exposed to oxidative stress during its life cycle.
Xingju Song +13 more
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Pramipexole enhances levodopa's therapeutic efficacy in Parkinson's disease: Role of glutaredoxin-1 (GRX1), peroxiredoxin3 (PRX3), thioredoxin (TRX), 8-hydroxy-2 -deoxyguanosine (8-OHDG), and neurosteroid dehydroepiandrosterone sulfate (DHEA-S) [PDF]
Journal of Medical BiochemistryBackground: Parkinson's disease (PD) is characterised by progressive neurodegeneration and dopamine deficiency. Levodopa remains a cornerstone treatment, but its longterm use is associated with motor complications and reduced efficacy.
Shu Yu, Qian Jinjun
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Glutaredoxin-1 modulates the NF-κB signaling pathway to activate inducible nitric oxide synthase in experimental necrotizing enterocolitis [PDF]
Molecular Therapy: Methods & Clinical DevelopmentInducible nitric oxide synthase (iNOS), regulated by nuclear factor kappa B (NF-κB), is crucial for intestinal inflammation and barrier injury in the progression of necrotizing enterocolitis (NEC). The NF-κB pathway is inhibited by S-glutathionylation of
Yunfei Zhang +10 more
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