Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1 [PDF]
Molecules, 2023 Trypanosoma brucei is a species of kinetoplastid causing sleeping sickness in humans and nagana in cows and horses. One of the peculiarities of this species of parasites is represented by their redox metabolism. One of the proteins involved in this redox
Annagiulia Favaro +5 more
doaj +4 more sources
Sputum Glutaredoxin 1 and Protein S-Glutathionylation in COPD [PDF]
AntioxidantsAlterations in glutathione and its metabolism contribute to oxidative stress in COPD, but the role of S-glutathionylation (PSSG) and its major regulator glutaredoxin 1 (Grx1) remains unclear.
Ine Kuipers +7 more
doaj +3 more sources
Glutaredoxin 1 regulates macrophage polarization through mediating glutathionylation of STAT1 [PDF]
Thoracic Cancer, 2020 Background Macrophage polarization affects tumor growth, metabolism, and many other tumor processes. M1 macrophages can promote antitumor immunity response.
Lijuan Guo +13 more
doaj +5 more sources
IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages. [PDF]
PLoS ONE, 2019 Interleukin (IL)-33 is an interleukin-1 like cytokine that enhances Th2 responses and mediates mucosal immunity and allergic inflammation but the mechanism regulating endogenous IL-33 production are still under investigation.
Ellen O Weinberg +6 more
doaj +6 more sources
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. [PDF]
PLoS ONE, 2017 Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates.
Olga Gorelenkova Miller +8 more
doaj +5 more sources
Temporal changes in glutaredoxin 1 and protein s-glutathionylation in allergic airway inflammation. [PDF]
PLoS ONE, 2015 Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation.
Kanako Maki +5 more
doaj +6 more sources
Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis [PDF]
Antioxidants, 2022 Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging.
Yuko Tsukahara +6 more
doaj +2 more sources
Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. [PDF]
Int J Mol Sci, 2020 Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to increase, discovering mechanisms and therapeutic targets become increasingly important. An underlying cause of most cardiovascular diseases is believed to be excess reactive oxygen or nitrogen species. Glutathione, the most abundant cellular antioxidant, plays an
Burns M +7 more
europepmc +4 more sources
Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites [PDF]
Journal of Pharmaceutical Analysis, 2023 Excessive N-acetyl-p-benzoquinone imine (NAPQI) formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen (APAP) overdose caused acute liver failure (ALF).
Ying Xu +12 more
doaj +2 more sources
Glutaredoxin 1 controls monocyte reprogramming during nutrient stress and protects mice against obesity and atherosclerosis in a sex-specific manner [PDF]
Nature Communications, 2022 High-calorie diet promotes thiol oxidative stress and the reprogramming of blood monocytes, giving rise to obesogenic and proatherogenic macrophages.
Yong Joo Ahn +5 more
doaj +2 more sources