Results 11 to 20 of about 9,840 (178)

A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer. [PDF]

Int J Mol Sci
Glutaredoxin 1 (Grx1) is an essential enzyme that regulates redox signal transduction and repairs protein oxidation by reversing S-glutathionylation, an oxidative modification of protein cysteine residues. Grx1 removes glutathione from proteins to restore their reduced state (protein-SH) and regulate protein-SSG levels in redox signaling networks. Thus,
Brzozowa-Zasada M, Piecuch A, Bajdak-Rusinek K, Gołąbek K, Michalski M, Matysiak N, Czuba Z.   +6 more
europepmc   +4 more sources

Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway [PDF]

Clinical and Translational Medicine, 2023
Background Lymphangioleiomyomatosis (LAM) is a female‐predominant interstitial lung disease, characterized by progressive cyst formation and respiratory failure.
Ya Feng, Tianjiao Li, Yin Li, Zhoujun Lin, Xiao Han, Xiaolin Pei, Yupeng Zhang, Fei Li, Juan Yang, Di Shao, Chenggang Li   +10 more
doaj   +3 more sources

Glutaredoxin-1 modulates the NF-κB signaling pathway to activate inducible nitric oxide synthase in experimental necrotizing enterocolitis [PDF]

Molecular Therapy: Methods & Clinical Development
Inducible nitric oxide synthase (iNOS), regulated by nuclear factor kappa B (NF-κB), is crucial for intestinal inflammation and barrier injury in the progression of necrotizing enterocolitis (NEC). The NF-κB pathway is inhibited by S-glutathionylation of
Yunfei Zhang, Mei Yan, Yingying Xia, Yingbin Yue, Shuli Wang, Yuhui Hu, Genjian Lai, Quanjiang Wu, Qianyang Liu, Xin Ding, Chunbao Guo   +10 more
doaj   +3 more sources

Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease. [PDF]

Biochemistry, 2016
Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidative modification of DJ-1 has been reported to regulate the protective activity of DJ-1 in vitro ...
Johnson WM, Golczak M, Choe K, Curran PL, Miller OG, Yao C, Wang W, Lin J, Milkovic NM, Ray A, Ravindranath V, Zhu X, Wilson MA, Wilson-Delfosse AL, Chen SG, Mieyal JJ.   +15 more
europepmc   +6 more sources

Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification [PDF]

Redox Biology, 2023
Oxidative stress drives protein S-glutathionylation, which regulates the structure and function of target proteins and is implicated in the pathogenesis of many diseases.
Chenshuang Li, Xi Chen, Siqi Zhang, Chen Liang, Xiaopan Ma, Ruixue Zhang, Hong Yan   +6 more
doaj   +3 more sources

Glutaredoxin 1 Deficiency Leads to Microneme Protein-Mediated Growth Defects in Neospora caninum [PDF]

Frontiers in Microbiology, 2020
Neospora caninum is an obligate intracellular protozoan parasite that infects a wide range of mammalian species and causes spontaneous abortion in cattle. N. caninum is exposed to oxidative stress during its life cycle.
Xingju Song, Xingju Song, Xu Yang, Xu Yang, Yangfei Xue, Yangfei Xue, Congshan Yang, Congshan Yang, Kaijian Wu, Kaijian Wu, Jing Liu, Jing Liu, Qun Liu, Qun Liu   +13 more
doaj   +2 more sources

Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B.
De Benedetto, M, CAPO, CONCETTA ROSA, Ferri, A, Valle, C, Polimanti, R, CARRI', MARIA TERESA, ROSSI, LUISA   +6 more
openaire   +5 more sources

Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling [PDF]

Free Radical Biology and Medicine, 2011
The transcription factor nuclear factor κB (NF-κB) is a critical regulator of inflammation and immunity and is negatively regulated via S-glutathionylation. The inhibitory effect of S-glutathionylation is overcome by glutaredoxin-1 (Grx1), which under physiological conditions catalyzes deglutathionylation and enhances NF-κB activation.
Aesif, S.W., Kuipers, I., van der Velden, J., Tully, J. E., Guala, A.S., Anathy, V., Sheely, J. I., Reynaert, N.L., Wouters, E.F.M., van der Vliet, A., Janssen-Heininger, Y.M.W.   +10 more
openaire   +3 more sources

Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease [PDF]

Redox Biology
Protein S-glutathionylation (PSSG), a redox-sensitive post-translational modification, regulates protein conformation and activity, potentially resulting in cell death.
Tiantian Zhang, Xiaofen Zhang, Huimei Cai, Mengli Yu, Qichen Liu, Xin Song, Bingru Lin, Linjie Xu, Lan Li, Zhe Shen, Chaohui Yu, Jie Zhang   +11 more
doaj   +2 more sources

Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice [PDF]

Movement Disorders, 2020
AbstractBackgroundParkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell death and cell survival signaling pathways in these neurons.
Aditi Verma, Ajit Ray, Deepti Bapat, Latha Diwakar, Reddy Peera Kommaddi, Bernard L. Schneider, Etienne C. Hirsch, Vijayalakshmi Ravindranath   +7 more
openaire   +4 more sources