IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages. [PDF]
PLoS ONE, 2019 Interleukin (IL)-33 is an interleukin-1 like cytokine that enhances Th2 responses and mediates mucosal immunity and allergic inflammation but the mechanism regulating endogenous IL-33 production are still under investigation.
Ellen O Weinberg +6 more
doaj +6 more sources
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. [PDF]
PLoS ONE, 2017 Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates.
Olga Gorelenkova Miller +8 more
doaj +5 more sources
Temporal changes in glutaredoxin 1 and protein s-glutathionylation in allergic airway inflammation. [PDF]
PLoS ONE, 2015 Asthma is a chronic inflammatory disorder of the airways, involving oxidative stress. Upon oxidative stress, glutathione covalently binds to protein thiols to protect them against irreversible oxidation.
Kanako Maki +5 more
doaj +6 more sources
Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease [PDF]
Redox BiologyProtein S-glutathionylation (PSSG), a redox-sensitive post-translational modification, regulates protein conformation and activity, potentially resulting in cell death.
Tiantian Zhang +11 more
doaj +2 more sources
Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification [PDF]
Redox Biology, 2023 Oxidative stress drives protein S-glutathionylation, which regulates the structure and function of target proteins and is implicated in the pathogenesis of many diseases.
Chenshuang Li +6 more
doaj +2 more sources
The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein
Neurology Research International, 2021 Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani +4 more
doaj +2 more sources
Making HEDS or tails of glutaredoxin catalysis: Direct reduction of bis(2-hydroxyethyl) disulfide as a non-glutathione disulfide substrate [PDF]
Redox BiologyThe bis(2-hydroxyethyl) disulfide (HEDS) steady-state assay is the most commonly used assay to measure the activity and kinetic parameters of glutaredoxins.
Lukas Lang +3 more
doaj +2 more sources
Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides.
CARRI', MARIA TERESA +9 more
core +5 more sources
The lineage-specific, intrinsically disordered N-terminal extension of monothiol glutaredoxin 1 from trypanosomes contains a regulatory region [PDF]
Scientific Reports, 2018 Glutaredoxins (Grx) are small proteins conserved throughout all the kingdoms of life that are engaged in a wide variety of biological processes and share a common thioredoxin-fold.
Mattia Sturlese +9 more
doaj +2 more sources
Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. [PDF]
Int J Mol Sci, 2020 Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to increase, discovering mechanisms and therapeutic targets become increasingly important. An underlying cause of most cardiovascular diseases is believed to be excess reactive oxygen or nitrogen species. Glutathione, the most abundant cellular antioxidant, plays an
Burns M +7 more
europepmc +4 more sources