Results 31 to 40 of about 9,840 (178)
Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity. [PDF]
PLoS ONE, 2017 The onset and progression of diabetes mellitus type 2 is highly contingent on the amount of functional beta-cell mass. An underlying cause of beta-cell decay in diabetes is oxidative stress, which markedly affects the insulin producing pancreatic cells ...
Sebastian Friedrich Petry +3 more
doaj +2 more sources
The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. [PDF]
Sci Adv, 2021 Activation of the hepatic stellate cells (HSCs) is a key pathogenic event in liver fibrosis. Protein S-glutathionylation (PSSG) of cysteine residues is a distinct form of oxidative response that modifies protein structures and functions.
Xi Y +19 more
europepmc +3 more sources
Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B. [PDF]
Sci Rep, 2020 Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble metallochaperones that participate in Cu exchange through highly tuned protein-protein interactions. Recently, the human enzyme
Maghool S +4 more
europepmc +3 more sources
Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice. [PDF]
Am J Respir Cell Mol Biol, 2016 Protein S-glutathionylation (PSSG) is an oxidant-induced post-translational modification of protein cysteines that impacts structure and function. The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutathionylation and ...
Hoffman SM +24 more
europepmc +2 more sources
Frontiers in Microbiology, 2023 The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be.
Stefanie S. Eben, James A. Imlay
doaj +1 more source
The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein
Neurology Research International, 2021 Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani +4 more
doaj +1 more source
Redox Biology, 2023 Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state.
Maria J. Ferreira +6 more
doaj +1 more source
Antioxidants, 2023 In premature infants receiving parenteral nutrition, oxidative stress is a trigger for the development of bronchopulmonary dysplasia, which is an important factor in the development of adult lung diseases. Neonatal vitamin C and glutathione deficiency is
Vitor Teixeira +2 more
doaj +1 more source
Modulation of Glutaredoxin-1 Expression in a Mouse Model of Allergic Airway Disease [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2007 Abstract Glutaredoxins (GRX) are antioxidant enzymes that preferentially catalyze the reduction of protein-glutathione mixed disulfides. The formation of mixed disulfides with GSH is known as S-glutathionylation, a post-translational modification that is emerging as an important mode of redox signaling.
Reynaert, N.L. +2 more
openaire +3 more sources
Antioxidants, 2022 Hypoxia is a major environmental stressor that can damage the oxidation metabolism of crustaceans. Glutaredoxin (Grx) is a key member of the thioredoxin superfamily and plays an important role in the host’s defense against oxidative stress.
Yu-Kun Jie +6 more
doaj +1 more source