Results 31 to 40 of about 107,521,968 (199)
Redox Biology, 2023 Despite the large amounts of H2O2 generated in mammalian peroxisomes, cysteine residues of intraperoxisomal proteins are maintained in a reduced state.
Maria J. Ferreira +6 more
doaj +1 more source
Activation of the glutaredoxin-1 gene by nuclear factor κB enhances signaling [PDF]
Free Radical Biology and Medicine, 2011 The transcription factor nuclear factor κB (NF-κB) is a critical regulator of inflammation and immunity and is negatively regulated via S-glutathionylation. The inhibitory effect of S-glutathionylation is overcome by glutaredoxin-1 (Grx1), which under physiological conditions catalyzes deglutathionylation and enhances NF-κB activation.
Aesif, S.W. +10 more
openaire +2 more sources
Antioxidants, 2023 In premature infants receiving parenteral nutrition, oxidative stress is a trigger for the development of bronchopulmonary dysplasia, which is an important factor in the development of adult lung diseases. Neonatal vitamin C and glutathione deficiency is
Vitor Teixeira +2 more
doaj +1 more source
Modulation of Glutaredoxin-1 Expression in a Mouse Model of Allergic Airway Disease [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2007 Abstract Glutaredoxins (GRX) are antioxidant enzymes that preferentially catalyze the reduction of protein-glutathione mixed disulfides. The formation of mixed disulfides with GSH is known as S-glutathionylation, a post-translational modification that is emerging as an important mode of redox signaling.
Reynaert, N.L. +2 more
openaire +3 more sources
Intracellular glutathione pools are heterogeneously concentrated [PDF]
, 2013 Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana +12 more
core +1 more source
Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. [PDF]
Antioxid Redox Signal, 2017 Aims: Nonalcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity, and diabetes that is rising in prevalence worldwide. Various molecular perturbations of key regulators and enzymes in hepatic lipid metabolism cause NAFL.
Shao D +10 more
europepmc +4 more sources
Antioxidants, 2022 Hypoxia is a major environmental stressor that can damage the oxidation metabolism of crustaceans. Glutaredoxin (Grx) is a key member of the thioredoxin superfamily and plays an important role in the host’s defense against oxidative stress.
Yu-Kun Jie +6 more
doaj +1 more source
Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. [PDF]
Antioxid Redox Signal, 2016 Aims: Neuroinflammation and redox dysfunction are recognized factors in Parkinson's disease (PD) pathogenesis, and diabetes is implicated as a potentially predisposing condition. Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts ...
Gorelenkova Miller O +7 more
europepmc +4 more sources
Journal of Lipid Research, 2006 Oxidative stress is thought to contribute to the initiation and progression of atherosclerosis. As glutathione peroxidase-1 (Gpx1) is an antioxidant enzyme that detoxifies lipid hydroperoxides, we tested the impact of Gpx1 deficiency on atherosclerotic ...
Judy B. de Haan +7 more
doaj +1 more source
Redox Biology, 2017 Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for ...
Vasco Branco +6 more
doaj +1 more source