Results 51 to 60 of about 107,521,968 (199)

RETRACTED: PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease

Molecules, 2021
Parkinson’s disease (PD) is characterized mainly by the loss of dopaminergic neurons in the substantia nigra (SN) mediated via oxidative stress. Although glutaredoxin-1 (GLRX1) is known as one of the antioxidants involved in cell survival, the effects of
Yeon Joo Choi, Dae Won Kim, Min Jea Shin, Hyeon Ji Yeo, Eun Ji Yeo, Lee Re Lee, Yejin Song, Duk-Soo Kim, Kyu Hyung Han, Jinseu Park, Keun Wook Lee, Jong Kook Park, Won Sik Eum, Soo Young Choi   +13 more
doaj   +1 more source

OxyR senses sulfane sulfur and activates the genes for its removal in Escherichia coli

Redox Biology, 2019
Sulfane sulfur species including hydrogen polysulfide and organic persulfide are newly recognized normal cellular components, and they participate in signaling and protect cells from oxidative stress.
Ningke Hou, Zhenzhen Yan, Kaili Fan, Huanjie Li, Rui Zhao, Yongzhen Xia, Luying Xun, Huaiwei Liu   +7 more
doaj   +1 more source

Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases

, 2022
Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease.
A., Haseena P., Diwakar, Latha, Vijayalakshmi Ravindranath, Haseena P. A., Latha Diwakar, Ravindranath, Vijayalakshmi, Haseena, P. A.   +6 more
core   +1 more source

Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation

Antioxidants, 2022
Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have shown ...
David A. Davis, Haydar Bulut, Prabha Shrestha, Hiroaki Mitsuya, Robert Yarchoan   +4 more
doaj   +1 more source

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Glutaredoxine reduzieren schnell Glutathionhydroper‐ und Glutathionpolysulfide

Angewandte Chemie, EarlyView.
Glutaredoxine (Grx) reduzieren Glutathionpolysulfide (GSSnSG) schnell zu Glutathionhydroper/polysulfiden (GSSnH) oder GSSnH zu Wasserstoff(poly)sulfiden (H2Sn). Die Reduktion glutathionylierter Grx durch reduziertes Glutathion (GSH) liefert Glutathiondisulfid (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

Glutaredoxin genes differentially expressed between the transgenic C4 plants and the transgenic Gfp control plants.

, 2022
Glutaredoxin genes differentially expressed between the transgenic C4 plants and the transgenic Gfp control plants.
Yi Zheng (113896), Andrea Gilliard (9948815), Kai-Shu Ling (163844), Zhangjun Fei (14143), Jennifer R. Wilson (10843124), Md Shamimuzzaman (6449240), Chellappan Padmanabhan (12536663)   +6 more
core   +1 more source

Involvement of glutaredoxin-1 and thioredoxin-1 in β-amyloid toxicity and Alzheimer's disease [PDF]

Cell Death & Differentiation, 2005
Strong evidence indicates oxidative stress in the pathogenesis of Alzheimer's disease (AD). Amyloid beta (Abeta) has been implicated in both oxidative stress mechanisms and in neuronal apoptosis. Glutaredoxin-1 (GRX1) and thioredoxin-1 (TRX1) are antioxidants that can inhibit apoptosis signal-regulating kinase (ASK1).
S, Akterin, R F, Cowburn, A, Miranda-Vizuete, A, Jiménez, N, Bogdanovic, B, Winblad, A, Cedazo-Minguez   +6 more
openaire   +2 more sources

Glutaredoxins Rapidly Reduce Glutathione Hydroper‐ and Polysulfides

Angewandte Chemie International Edition, EarlyView.
Glutaredoxins (Grx) rapidly reduce glutathione polysulfides (GSSnSG) to glutathione hydroper/polysulfides (GSSnH) or GSSnH to hydrogen (poly)sulfides (H2Sn). Reduction of glutathionylated glutaredoxins by reduced glutathione (GSH) yields glutathione disulfide (GSSG).
Philipp Reinert, Seiryo Ogata, Laura Leiskau, Sernur Sena Yildiz, Takaaki Akaike, Uladzimir Barayeu, Marcel Deponte   +6 more
wiley   +1 more source

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses. [PDF]

, 2019
Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance.
Helen Thut, Krüger, Caroline C., Thut, H., Krueger, Caroline C., Heer, S., Martin F. Bachmann, Bornkamm, G.W., Muri, J., Kopf, Manfred, Georg W. Bornkamm, Thut, Helen, Kopf, M., Jonathan Muri, Sebastian Heer, Caroline C. Krueger, Bachmann, Martin F., Muri, Jonathan, Bornkamm, Georg W., Bachmann, M.F., Bornkamm, Georg W, Manfred Kopf, Heer, Sebastian, Krueger, C.C., Krueger CC, Thut H, Muri J, Heer S, Bachmann MF, Bornkamm GW, Kopf M   +29 more
core   +2 more sources