Insights into the Multifaceted Roles of Thioredoxin-1 System: Exploring Knockout Murine Models
BiologyRedox balance is increasingly identified as a major player in cellular signaling. A fundamentally simple reaction of oxidation and reduction of cysteine residues in cellular proteins is the central concept in this complex regulatory mode of protein ...
Tetiana Shcholok, Eftekhar Eftekharpour
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, 2007 Glutaredoxin and glutathione play a role in regulating the activity of the copper transporting ATPases, ATP7A and ...
M Cater (13694599) +5 more
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Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B. [PDF]
Sci Rep, 2020 Maghool S +4 more
europepmc +1 more source
, 2008 Glutaredoxin and glutathione play a role in regulating the activity of the copper transporting ATPases, ATP7A and ...
M Cater (13694599) +5 more
core
Monothiol and dithiol glutaredoxin-1 from <i>Clostridium oremlandii</i>: identification of domain-swapped structures by NMR, X-ray crystallography and HDX mass spectrometry. [PDF]
IUCrJ, 2020 Lee K +12 more
europepmc +1 more source
Isoforms of mammalian glutaredoxin 2
, 2009 Iron-sulfur proteins are characterized by the presence of iron-sulfur clusters containing sulfide linked iron centers in variable oxidation states. Glutaredoxins (Grx) are, among other redoxins, increasingly recognized to be involved at the interface ...
Christoph Hudemann (9593570)
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Paradoxical enhancement of oxidative stress-induced DNA damage and impaired redox homeostasis by Glutaredoxin 1 overexpression in human HeLa cells. [PDF]
J Radiat ResZhao T +4 more
europepmc +1 more source
Glutaredoxin-1 attenuates transactive response DNA-binding protein 43-induced neurotoxicity by suppressing oxidative stress and transactive response DNA-binding protein 43 aggregation. [PDF]
NeuroreportLee JM, Bok E, Kim SR, Kim J.
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