Results 21 to 30 of about 3,189 (173)
Antioxidants, 2020 The thioredoxin family consists of a small group of redox proteins present in all organisms and composed of thioredoxins (TRXs), glutaredoxins (GLRXs) and peroxiredoxins (PRDXs) which are found in the extracellular fluid, the cytoplasm, the mitochondria ...
Marta Seco-Cervera +4 more
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Silver Binding to Bacterial Glutaredoxins Observed by NMR
Biophysica, 2021 Glutaredoxins (GRXs) are a class of enzymes used in the reduction of protein thiols and the removal of reactive oxygen species. The CPYC active site of GRX is a plausible metal binding site, but was previously theorized not to bind metals due to its cis ...
Stephanie M. Bilinovich +8 more
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Molecular basis for the distinct functions of redox-active and FeS-transfering glutaredoxins
Nature Communications, 2020 Glutaredoxins are a family of essential enzymes divided into two major classes with either a CGFS or a CxxC active site, of which only the latter exhibits oxidoreductase activity.
Daniel Trnka +14 more
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BMC Plant Biology, 2022 Background We previously identified six drought-inducible CC-type glutaredoxins in cassava cultivars, however, less is known about their potential role in the molecular mechanism by which cassava adapted to abiotic stress.
Meng-Bin Ruan +4 more
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Memorias do Instituto Oswaldo Cruz, 2012 To cope with oxidative stress, Candida albicans possesses several enzymes involved in a number of biological processes, including superoxide dismutases (Sods) and glutaredoxins (Grxs). The resistance of C.
Guilherme Maranhão Chaves +1 more
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The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function
Experimental Eye Research, 2023 Glutaredoxins (Grx1 and Grx2) are thiol-repair antioxidant enzymes that play vital roles in cellular redox homeostasis and various cellular processes. This study aims to evaluate the functions of the glutaredoxin (Grx) system, including glutaredoxin 1 (Grx1) and glutaredoxin 2 (Grx2), using Grx1/Grx2 double knockout (DKO) mice as a model.
Jinmin, Zhang +4 more
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Cloning, Overexpression, and Characterization of Glutaredoxin 2, An Atypical Glutaredoxin from Escherichia coli [PDF]
Journal of Biological Chemistry, 1997 Glutaredoxin 2 (Grx2) from Escherichia coli catalyzes GSH-disulfide oxidoreductions via two redox-active cysteine residues, but in contrast to glutaredoxin 1 (Grx1) and glutaredoxin 3 (Grx3), is not a hydrogen donor for ribonucleotide reductase. To characterize Grx2, a chromosomal fragment containing the E.
A, Vlamis-Gardikas +4 more
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Glutaredoxin catalysis requires two distinct glutathione interaction sites
Nature Communications, 2017 Glutaredoxins have important roles in redox processes. Here the authors show that the enzymatic activity of glutaredoxins requires two distinct glutathione interactions sites, one recognizing the glutathione disulfide substrate and one activating ...
Patricia Begas +4 more
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Is There a Role for Glutaredoxins and BOLAs in the Perception of the Cellular Iron Status in Plants?
Frontiers in Plant Science, 2019 Glutaredoxins (GRXs) have at least three major identified functions. In apoforms, they exhibit oxidoreductase activity controlling notably protein glutathionylation/deglutathionylation.
Pascal Rey +4 more
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Glutaredoxins and thioredoxins in plants
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2008 During the 70s and 80s two plant thioredoxin systems were identified. The chloroplastic system is composed of a ferredoxin-dependent thioredoxin, with two thioredoxin types (m and f) regulating the activity of enzymes implicated in photosynthetic carbon assimilation. In the cytosol of heterotrophic tissues, an NADP dependent thioredoxin reductase and a
Meyer, Yves +5 more
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