Results 91 to 100 of about 122,606 (315)

Mitochondrial thiol-disulfide system under acute hypoxia and hypoxic-hyperoxic adaptation [PDF]

The Ukrainian Biochemical Journal, 2014
The authors investigated the state of mitochondrial glutathione pool (reduced and oxidized glutathione, protein-GSH mixed disulfides), content of carbonyl groups and free sulfhydryl groups of proteins, protein expression of key mitochondrial antioxidant ...
O. A. Gonchar, I. N. Mankovska
doaj   +1 more source

GPx4 is bound to peroxidized membranes by a hydrophobic anchor [PDF]

Ferroptosis is a form of cell death discovered in recent years, induced by excessive peroxidation of phospholipids. Glutathione peroxidase 4 (GPx4) is an intracellular enzyme that can repair the peroxidized phospholipids on membranes, thus regulating ferroptosis.
arxiv   +1 more source

Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization [PDF]

, 2017
We previously demonstrated that the nuclear form of Glutathione peroxidase 4 (nGPx4) has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome and that sperm lacking nGPx4 are more prone to decondensation in vitro. In this
Boitani, Carla, Esposito, Valentina, Fiorenza, Maria T., Fuso, Andrea, Lucarelli, Marco, Mangia, Franco, Mularoni, Valentina, Pipolo, Simona, Puglisi, Rossella   +8 more
core   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Glutathione, glutathione peroxidase and some hematological parameters of HIV-seropositive subjects attending clinic in University of Calabar teaching hospital, Calabar, Nigeria

BMC Infectious Diseases, 2019
Background Despite the numerous intervention programmes, HIV still remains a public health concern with a high impact in Sub-Saharan Africa region. Oxidative stress has been documented in HIV subjects as viral infection promotes prolonged activation of ...
Stephen Bassey Coco-Bassey, Enosakhare A. Asemota, Henshaw Uchechi Okoroiwu, Joyce E. Etura, Esienanwan Esien Efiong, Imeobong J. Inyang, Emmanuel K. Uko   +6 more
doaj   +1 more source

Dimethyl Fumarate Alleviates Dextran Sulfate Sodium-Induced Colitis, through the Activation of Nrf2-Mediated Antioxidant and Anti-inflammatory Pathways. [PDF]

, 2020
Oxidative stress and chronic inflammation play critical roles in the pathogenesis of ulcerative colitis (UC) and inflammatory bowel diseases (IBD). A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium ...
Farzaneh, Ted, Ichii, Hirohito, Lau, Hien, Li, Shiri, Robles, Lourdes, Stamos, Michael J, Takasu, Chie, Vaziri, Nosratola D, Vo, Kelly   +8 more
core   +2 more sources

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Immunohistochemical pitfalls in the demonstration of insulin-degrading enzyme in normal and neoplastic human tissues [PDF]

arXiv, 2007
Previously, we have identified the cytoplasmic zinc metalloprotease insulin-degrading enzyme(IDE) in human tissues by an immunohistochemical method involving no antigen retrieval (AR) by pressure cooking to avoid artifacts by endogenous biotin exposure and a detection kit based on the labeled streptavidin biotin (LSAB) method. Thereby, we also employed
arxiv  

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source