Results 31 to 40 of about 151,919 (337)

Remote ischemic conditioning improves rat brain antioxidant defense in a time-dependent mechanism

Acta Cirúrgica Brasileira, 2021
Purpose To clarify the best protocol for performing remote ischemic conditioning and to minimize the consequences of ischemia and reperfusion syndrome in brain, the present study aimed to evaluate different time protocols and the relation of the organs ...
Andrew Moraes Monteiro, Rodrigo Paracampo Couteiro, Dora Fonseca da Silva, Sérgio Cunha Trindade Júnior, Renata Cunha Silva, Luís Fernando Freitas de Sousa, Deivid Ramos dos Santos, Jofre Jacob da Silva Freitas, Marcus Vinícius Henriques Brito   +8 more
doaj   +1 more source

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Effect of ochratoxin A and buthionine sulfoximine on proteome and ascorbate-glutathione cycle enzymes in Arabidopsis thaliana

Biologia Plantarum, 2015
In this study, proteome and activities of glutathione (GSH)-related enzymes were investigated in detached leaves of Arabidopsis thaliana treated with ochratoxin A (OTA) alone or supplemented with buthionine sulfoximine (BSO, a specific inhibitor of the ...
J. R. Hao, Y. Wang, W. W. Zhao, W. T. Xu, Y. B. Luo, Z. J. Yang, W. H. Wu, Z. H. Liang, K. L. Huang   +8 more
doaj   +1 more source

Praseodymium enhanced the tolerance of maize seedlings subjected to cadmium stress by up-regulating the enzymes in the regeneration and biosynthetic pathways of ascorbate and glutathione

Plant, Soil and Environment, 2021
To test whether praseodymium (Pr) regulates cadmium (Cd) tolerance, we explored the effects of Pr on enzymatic activities in the regeneration and biosynthetic pathways of ascorbate and glutathione in maize seedlings under Cd stress.
Qidi Zhu, Yanyan Li, Shang Gao, Changjuan Shan   +3 more
doaj   +1 more source

Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase [PDF]

Oxidative Medicine and Cellular Longevity, 2017
Neuronal degeneration in multiple sclerosis has been linked to oxidative stress. Dimethyl fumarate (DMF) is an effective oral therapeutic option shown to reduce disease activity and progression in patients with relapsing‐remitting multiple sclerosis. DMF activates the transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) leading to ...
Christina Hoffmann, Michael Dietrich, Ann-Kathrin Herrmann, Teresa Schacht, Philipp Albrecht, Axel Methner   +5 more
openaire   +4 more sources

Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D [PDF]

, 2008
In the present study, we used a recombinant filamentous fungus strain, Aspergillus niger B1-D, as a model system, and investigated the antioxidant defences in this organism.
Harvey, L.M., Li, Qiang, Mcneil, Brian
core   +1 more source

Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity

Brazilian Journal of Medical and Biological Research, 2006
Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species.
P.R.T. Romão, J. Tovar, S.G. Fonseca, R.H. Moraes, A.K. Cruz, J.S. Hothersall, A.A. Noronha-Dutra, S.H. Ferreira, F.Q. Cunha   +8 more
doaj   +1 more source

Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER [PDF]

, 2017
Folding of proteins entering the secretory pathway in mammalian cells frequently requires the insertion of disulfide bonds. Disulfide insertion can result in covalent linkages found in the native structure as well as those that are not, so‐called non ...
Elias SJ Arnér, Fourie AM, Greg J Poet, Marcel Lith, Marie Anne Pringle, Neil J Bulleid, Ojore BV Oka, Philip J Robinson, Zhenbo Cao   +8 more
core   +2 more sources

The Effect of an Aqueous Extract of Teucrium polium on Glutathione Homeostasis In Vitro: A Possible Mechanism of Its Hepatoprotectant Action

Advances in Pharmacological Sciences, 2010
Background. Teucrium polium is used in Arab traditional medicine to treat liver diseases. Glutathione is an important intracellular antioxidant, and intrahepatic glutathione levels are depleted in liver diseases. Hypothesis and Aim.
Stella Shtukmaster, Predrag Ljubuncic, Arieh Bomzon   +2 more
doaj   +1 more source

The binding of the retro-analogue of glutathione disulfide to glutathione reductase. [PDF]

Journal of Biological Chemistry, 1990
The retro-analogue of glutathione disulfide was bound to the GSSG binding site of crystalline glutathione reductase. The binding mode revealed why the analogue is a very poor substrate in enzyme catalysis. The observed binding mode difference between natural substrate and retro-analogue is explained.
Georg E. Schulz, W Janes
openaire   +2 more sources