Results 41 to 50 of about 164,189 (356)

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]

, 2014
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results
Armand, Lucie, Aude-Garcia, Catherine, Carrière, Marie, Collin-Faure, Véronique, Diemer, Hélène, Gerdil, Adèle, Habert, Aurélie, Hanau, Daniel, Herlin, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +13 more
core   +4 more sources

Nitric oxide donor SNP regulates the ascorbate and glutathione metabolism in Agropyron cristatum leaves through MEK1/2

Biologia Plantarum, 2017
This study investigated the role of the protein kinase MEK1/2 in the regulation of ascorbate and glutathione metabolism by nitric oxide in Agropyron cristatum leaves.
C. Shan, N. Dong
doaj   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +4 more sources

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin [PDF]

, 2020
Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction ...
Bäumler, Hans, Georgieva, Radostina, Kao, Ijad, Pruß, Axel, Suwannasom, Nittiya   +4 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice

Molecules, 2015
Parasitic flatworms cause serious infectious diseases that affect humans and livestock in vast regions of the world, yet there are few effective drugs to treat them. Thioredoxin glutathione reductase (TGR) is an essential enzyme for redox homeostasis in
Vivian Pasquet, Hugo Bisio, Gloria V. López, Laura Romanelli-Cedrez, Mariana Bonilla, Jenny Saldaña, Gustavo Salinas   +6 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Glutathione metabolism system under condition of transplantation of muscle tissue in rats

Regulatory Mechanisms in Biosystems, 2015
The paper presents the results of determining the amount of reduced glutathione, glutathione reductase and glutathione peroxidase activity at transplantation of muscle tissue taken from rats from the same litter.
O. V. Kulibaba, S. M. Kozishkurt, O. O. Duzenko, I. L. Vovchuk, S. A. Petrov   +4 more
doaj   +1 more source

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Bioaccumulation and biochemical responses in mussels exposed to the water-accommodated fraction of the Prestige fuel oil

Scientia Marina, 2007
The activity of the antioxidant defences catalase (CAT, EC 1.11.1.6), glutathione peroxidase (t-GPX, EC 1.11.1.9), glutathione reductase (GR, EC 1.6.4.2), phase II glutathione S-transferase (GST, EC 2.5.1.18) along with the NADPH-dependent cytochrome c ...
Montserrat Solé, Astrid Buet, Laura Ortiz, Francesc Maynou, Josep Maria Bayona, Joan Albaigés   +5 more
doaj   +1 more source