Results 41 to 50 of about 147,440 (362)
Brazilian Journal of Medical and Biological Research, 2006 Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species.
P.R.T. Romão +8 more
doaj +1 more source
The NAD(P)H:flavin oxidoreductase from Escherichia coli. Evidence for a new mode of binding for reduced pyridine nucleotides [PDF]
The journal of biological chemistry, American Society for
Biochemistry and Molecular Biology, 1999, 274, pp.18252-60, 2015 The NAD(P)H:flavin oxidoreductase from Escherichia coli, named Fre, is a monomer of 26.2 kDa that catalyzes the reduction of free flavins using NADPH or NADH as electron donor. The enzyme does not contain any prosthetic group but accommodates both the reduced pyridine nucleotide and the flavin in a ternary complex prior to oxidoreduction.
arxiv +1 more source
Glutathione conjugates of the mercapturic acid pathway and guanine adduct as biomarkers of exposure to CEES, a sulfur mustard analog [PDF]
, 2021 Sulfur mustard (SM), a chemical warfare agent, is a strong alkylating compound that readily reacts with numerous biomolecules. The goal of the present work was to define and validate new biomarkers of exposure to SM that could be easily accessible in urine or plasma. Because investigations using SM are prohibited by the Organization for the Prohibition
arxiv +1 more source
Serum Glutathione Reductase and Cystic Fibrosis [PDF]
Pediatric Research, 1975 Serum glutathione reductase (NADPH-GSSG oxidoreductase, EC. 1.6.4.2 (GR)) has been examined in cystic fibrosis subjects (CF), obligate CF heterozygotes, and control subjects. Serum protein concentration was similar in the three groups. Regardless of the units used to express activity (milligrams of protein or milliters of serum) or whether or not ...
Q. T. Smith +2 more
openaire +2 more sources
Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]
, 2017 Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio +1 more
core +1 more source
Plant, Soil and Environment, 2021 To test whether praseodymium (Pr) regulates cadmium (Cd) tolerance, we explored the effects of Pr on enzymatic activities in the regeneration and biosynthetic pathways of ascorbate and glutathione in maize seedlings under Cd stress.
Qidi Zhu +3 more
doaj +1 more source
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]
Mol Cell Proteomics 12, 11 (2013) 3108-22, 2013 The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model. Both metallic copper and copper oxide nanoparticles have been tested, with copper ion and zirconium oxide nanoparticles used as controls.
arxiv +1 more source
Understanding cisplatin resistance using cellular models [PDF]
, 2007 Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core +2 more sources
Biologia Plantarum, 2017 This study investigated the role of the protein kinase MEK1/2 in the regulation of ascorbate and glutathione metabolism by nitric oxide in Agropyron cristatum leaves.
C. Shan, N. Dong
doaj +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source