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Glutathione Conjugates of Hydralazine Formed in Theperoxidase/Hydrogen Peroxide/Glutathione System
1991The antihypertensive drug hydralazine is associated withthe induction of symptoms similar to systemic lupuserythematosus (Perry, 1973); it is also associated withlung tumors in mice (Toth, 1978), is mutagenic inseveral short term bacterial and mammalian cell assays (Williams et.
L G, McGirr, P J, O'Brien
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Antioxidants & Redox Signaling, 2017
Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there is a strong correlation between elevated levels
Elie, Hatem +2 more
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Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there is a strong correlation between elevated levels
Elie, Hatem +2 more
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Glutathione system in erythrocytes and plasma in viral hepatites
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2007In all 5 acute (AVHs) and chronic viral hepatites (CVHs) there was the increase of erythrocyte activities of glutathione peroxidase (GPx) and glutathione reductase (GR), and the decrerase in GSH concentration. In blood plasma there was accumulation of GPx, glutathione S-transferase (GST) and y-glutamyl transferase (gammaGT).
V I, Kulinskiĭ +4 more
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Effects of exercise training on the glutathione antioxidant system
European Journal of Cardiovascular Prevention & Rehabilitation, 2007Purpose The glutathione (GSH) antioxidant system has been shown to play an important role in the maintenance of good health and disease prevention. Various approaches have been used to enhance GSH availability including diet, nutritional supplementation, and drug administration, with minor to moderate success.
Ahmed S, Elokda, David H, Nielsen
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A Combined System for the Study of Glutathione Metabolism in Erythrocytes
Hemoglobin, 1980A combined system for measuring glutathione stability, hexose monophosphate pathway activity, glutathione synthesis, glucose consumption and lactate formation in erythrocytes has been devised. By this method the results were obtained from the blood samples of six glucose 6-phosphate dehydrogenase deficiencies, one glucose phosphate isomerase deficiency
Y, Ishida, S, Miwa
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Tocopherols, Carotenoids and The Glutathione System
1992Reactive oxygen species occur in tissues and can damage DNA, proteins, carbohydrates, and lipids. These potentially deleterious reactions are controlled by a system of enzymatic and nonenzymatic antioxidants which eliminate pro-oxidants and scavenge free radicals.
Helmut Sies +3 more
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Oxidation of glutathione by the myeloperoxidase system.
Journal of the Reticuloendothelial Society, 1982Oxidation of glutathione (GSH) by the myeloperoxidase (MPO) system was studied. The combination of MPO, H2O2, and a halide ion oxidized GSH. This occurred at a H2O2 concentration too low to oxidize GSH by itself. The MPO-mediated oxidation of GSH required the simultaneous presence of MPO, H2O2, and a halide ion.
R M, Turkall, M F, Tsan
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The Glutathione–Glutathione Disulfide System
1976Nechama S. Kosower, Edward M. Kosower
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[Resistance associated with the glutathione system].
Bulletin du cancer, 1995Several mechanisms of resistance (of bacteria to antibiotics, of plants to herbicides, of insects to insecticides, of cancer cells to cytotoxic agents...) have now been described. The most studied one is the glycoprotein coded by the mdr1 gene, which is involved in the efflux of numerous compounds of natural origin (anthracyclines, podophyllotoxins...)
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Photoaffinity labels for glutathione- and glutathione disulphide-utilizing systems
Biochemical Society Transactions, 1982KENNETH T. DOUGLAS +3 more
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