Results 211 to 220 of about 18,229,039 (247)
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Selenoproteins of the glutathione system
2001The protein family of glutathione peroxidases (GPx) is found throughout the entire life kingdoms. Five distinct molecular clades characterized by an active site selenocysteine residue may coexist in vertebrates. All selenocysteine-containing GPx types reduce hydroperoxides with rate constants k’1 near 107 M−1 sec−1, while the cysteine homologs are poor
Leopold Flohé, Regina Brigelius-Flohé
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Systemic deficiency of glutathione in cystic fibrosis
Journal of Applied Physiology, 1993Cystic fibrosis (CF), a disorder characterized by mutations of the CF transmembrane regulator gene, is characterized in the lung by chronic inflammation, leading to progressive damage to the airway epithelium, bronchiectasis, and chronic obstructive lung disease.
J H, Roum +4 more
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Age‐related changes in the glutathione redox system
Cell Biochemistry and Function, 2001AbstractThe effect of aging on the glutathione redox system was evaluated in this study. For this purpose, we determined reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood, glutathione peroxidase (GPx) and glutathione reductase (GSSGR) in erythrocytes and selenium (Se) in plasma in 176 healthy individuals.
Kanbak, GÜNGÖR +2 more
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[Glutathione system. I. Synthesis, transport, glutathione transferases, glutathione peroxidases].
Biomeditsinskaia khimiia, 2009Studies of glutathione system in all basic trends have been extended considerably during recent 10-15 years. A series of new metabolic enzymes has been discovered. Many of them are polyfunctional and their new activities have been recognized. The enzymes interact with hormones and signal transduction systems. The studies of intracellular, intercellular
V I, Kulinskiĭ, L S, Kolesnichenko
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Glutathione Conjugates of Hydralazine Formed in Theperoxidase/Hydrogen Peroxide/Glutathione System
1991The antihypertensive drug hydralazine is associated withthe induction of symptoms similar to systemic lupuserythematosus (Perry, 1973); it is also associated withlung tumors in mice (Toth, 1978), is mutagenic inseveral short term bacterial and mammalian cell assays (Williams et.
L G, McGirr, P J, O'Brien
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Tocopherols, Carotenoids and The Glutathione System
1992Reactive oxygen species occur in tissues and can damage DNA, proteins, carbohydrates, and lipids. These potentially deleterious reactions are controlled by a system of enzymatic and nonenzymatic antioxidants which eliminate pro-oxidants and scavenge free radicals.
Helmut Sies +3 more
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A combined system for the study of glutathione metabolism in erythrocytes
Clinica Chimica Acta, 1979Abstract A combined system for measuring glutathione stability, hexose monophosphate shunt activity, glycine incorporation into glutathione, glucose consumption and lactate formation in erythrocytes has been devised. In severe glucose-6-phosphate dehydrogenase deficiency associated with chronic hemolytic anemia, extremely small amounts of glucose ...
Y, Ishida +3 more
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Effects of exercise training on the glutathione antioxidant system
European Journal of Cardiovascular Prevention & Rehabilitation, 2007Purpose The glutathione (GSH) antioxidant system has been shown to play an important role in the maintenance of good health and disease prevention. Various approaches have been used to enhance GSH availability including diet, nutritional supplementation, and drug administration, with minor to moderate success.
Ahmed S, Elokda, David H, Nielsen
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Glutathione system in erythrocytes and plasma in viral hepatites
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2007In all 5 acute (AVHs) and chronic viral hepatites (CVHs) there was the increase of erythrocyte activities of glutathione peroxidase (GPx) and glutathione reductase (GR), and the decrerase in GSH concentration. In blood plasma there was accumulation of GPx, glutathione S-transferase (GST) and y-glutamyl transferase (gammaGT).
V I, Kulinskiĭ +4 more
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The Glutathione–Glutathione Disulfide System
1976Nechama S. Kosower, Edward M. Kosower
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