Results 211 to 220 of about 320,403 (261)
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Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology, 2007
The physiological roles of the glutathione(GSH)/glutathione peroxidase(GPx) system in protecting microbial cells against oxidative stress were reviewed. In eukaryotic model microbe Saccharomyces cerevisiae,this system is obligatory in maintaining the redox balance and defending the oxidative stress. However, the GSH/GPx system only conditionally exists
Yin Li
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The physiological roles of the glutathione(GSH)/glutathione peroxidase(GPx) system in protecting microbial cells against oxidative stress were reviewed. In eukaryotic model microbe Saccharomyces cerevisiae,this system is obligatory in maintaining the redox balance and defending the oxidative stress. However, the GSH/GPx system only conditionally exists
Yin Li
exaly +3 more sources
The glutathione defense system in the pathogenesis of rheumatoid arthritis
Journal of Applied Toxicology, 2001AbstractIn order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (RA), serum reduced glutathione levels (GSH), glutathione reductase (GSR), glutathione S‐transferase (GST), glutathione peroxidase (GSH‐Px) and alkaline phosphatase (ALP) activities, lipid peroxidation (MDA content) and ...
S J Stohs
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Glutathione Redox System in Oxidative Lung Injury
Critical Reviews in Toxicology, 1999Glutathione (GSH) is a ubiquitous intracellular thiol present in all tissues, including lung. Besides maintaining cellular integrity by creating a reduced environment, GSH has multiple functions, including detoxification of xenobiotics, synthesis of proteins, nucleic acids, and leukotrienes.
Qamar Rahman +2 more
exaly +3 more sources
A semiautomated system for measurement of glutathione in the assay of glutathione peroxidase
Analytical Biochemistry, 1978Abstract The most commonly used assay procedures for measurement of glutathione (GSH) peroxidase are unsuitable for kinetic studies; therefore, a semiautomated system that is based upon the 5,5′-dithio-bis-2-nitrobenzoic acid (DTNB) reaction with sulfhydryls was developed for the assay of relatively purified samples of the enzyme.
J J, Zakowski, A L, Tappel
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A novel interaction of diethyldithiocarbamate with the glutathione/glutathione peroxidase system
International Journal of Radiation Oncology*Biology*Physics, 1986Diethyldithiocarbamate (DDC) exhibits a variety of pharmacologic activities, including both radioprotective and sensitizing properties. Since the glutathione/glutathione peroxidase system may be a significant factor in determining radiation sensitivity, the potential mechanisms of action of DDC in relation to this system were examined in vitro.
K S, Kumar, A M, Sancho, J F, Weiss
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The systemic availability of oral glutathione
European Journal of Clinical Pharmacology, 1992When the plasma glutathione concentration is low, such as in patients with HIV infection, alcoholics, and patients with cirrhosis, increasing the availability of circulating glutathione by oral administration might be of therapeutic benefit. To assess the feasibility of supplementing oral glutathione we have determined the systemic availability of ...
Witschi A +3 more
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The biochemistry of selenium and the glutathione system
Environmental Toxicology and Pharmacology, 2001In the context of defense against pro-oxidants, selenium and the glutathione (GSH) system play key functions. Major roles of GSH include direct interception of pro-oxidants, as well as a reduction of other antioxidants from their oxidized forms. Furthermore, GSH has ancillary functions, such as metabolism, cell signaling, and protein interactions, that
G E, Arteel, H, Sies
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The glutathione system in Parkinson’s disease and its progression
Neuroscience & Biobehavioral Reviews, 2021Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and progression of Parkinson's disease (PD). Glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio are lowered in oxidative stress conditions and may lead to increased oxidative toxicity.
Bjorklund, G +4 more
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Glutathione Transport System in NIH3T3 Fibroblasts
Molecular Cell Biology Research Communications, 2000The current study characterizes a mediated transport for GSH uptake in murine fibroblasts NIH3T3. The presence of GSH mediated transport is indicated by the behaviour of GSH uptake time-course, as well as by kinetic saturation and the specific inhibition of the initial rate of GSH transport. Moreover, a concentrative GSH uptake has been measured, whose
FAVILLI, FABIO +3 more
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The Glutathione System in Alkylator Resistance
2002One of the greatest obstacles in the effective chemotherapy of neoplastic disease is the presence of tumor chemoresistance. In some instances, a tumor can be intrinsically resistant to chemotherapy or, in other cases, develop resistance during the course of antineoplastic treatment.
David, Hamilton +2 more
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