Results 221 to 230 of about 320,403 (261)
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The glutathione system. I. Synthesis, transport, glutathione transferases, glutathione peroxidases
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2009Studies of glutathione system in all basic trends have been extended considerably during recent 10-15 years. A series of new metabolic enzymes has been discovered. Many of them are polyfunctional and their new activities have been recognized. The enzymes interact with hormones and signal transduction systems. The studies of intracellular, intercellular
V. I. Kulinsky, L. S. Kolesnichenko
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Linked thioredoxin-glutathione systems in platyhelminths
Trends in Parasitology, 2004The thioredoxin and glutathione systems play a central role in thiol-disulfide redox homeostasis in many organisms by providing electrons to essential enzymes, and defence against oxidative stress. These systems have recently been characterized in platyhelminth parasites, and the emerging biochemical scenario is the existence of linked processes with ...
Gustavo, Salinas +4 more
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Glutathione-mediated detoxification systems in plants
Current Opinion in Plant Biology, 1998Recent work has highlighted the presence of diverse glutathione-dependent enzymes in plants with potential roles in the detoxification of both xenobiotic and endogenous compounds. In particular, studies on glutathione transferases are further characterising their role in xenobiotic metabolism, and also raising intriguing possible roles in endogenous ...
D P, Dixon +3 more
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Clinical significance of the glutathione-conjugating system
Pharmacological Research Communications, 1983Glutathione displays important functions in living cells of many species, human included. Apart from its direct antioxidative activity, which supports the maintenance of the reduced state of proteinthiols, and its possible role in amino acid transport across membranes, it appears to exert several detoxification functions.
C P, Siegers, M, Younes
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Glutathione Metabolism and Some Possible Functions of Glutathione in the Nervous System
1976Publisher Summary Glutathione is the most ubiquitous peptide found in living cells. It plays an important role as a coenzyme in several enzymic reactions. The enzymic reactions of the synthesis and degradation of glutathione are linked in a cyclic process called “γ-glutamyl cycle.” The cycle functions in amino acid transport.
M, Orlowski, A, Karkowsky
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Systemic deficiency of glutathione in cystic fibrosis
Journal of Applied Physiology, 1993Cystic fibrosis (CF), a disorder characterized by mutations of the CF transmembrane regulator gene, is characterized in the lung by chronic inflammation, leading to progressive damage to the airway epithelium, bronchiectasis, and chronic obstructive lung disease.
J H, Roum +4 more
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Glutathione systems and anoxia tolerance in turtles
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1997Effects of anoxic submergence (20 h at 5 degrees C) and subsequent 24 h aerobic recovery on glutathione levels and the activities of glutathione-related enzymes were examined in six tissues of Trachemys scripta elegans. Anoxia exposure resulted in tissue-specific changes in enzyme maximal activities, the most dramatic being suppression of gamma ...
W G, Willmore, K B, Storey
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Selenoproteins of the glutathione system
2001The protein family of glutathione peroxidases (GPx) is found throughout the entire life kingdoms. Five distinct molecular clades characterized by an active site selenocysteine residue may coexist in vertebrates. All selenocysteine-containing GPx types reduce hydroperoxides with rate constants k’1 near 107 M−1 sec−1, while the cysteine homologs are poor
Leopold Flohé, Regina Brigelius-Flohé
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Age‐related changes in the glutathione redox system
Cell Biochemistry and Function, 2001AbstractThe effect of aging on the glutathione redox system was evaluated in this study. For this purpose, we determined reduced glutathione (GSH) and oxidized glutathione (GSSG) in whole blood, glutathione peroxidase (GPx) and glutathione reductase (GSSGR) in erythrocytes and selenium (Se) in plasma in 176 healthy individuals.
Mine, Erden-Inal +2 more
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[Glutathione system. I. Synthesis, transport, glutathione transferases, glutathione peroxidases].
Biomeditsinskaia khimiia, 2009Studies of glutathione system in all basic trends have been extended considerably during recent 10-15 years. A series of new metabolic enzymes has been discovered. Many of them are polyfunctional and their new activities have been recognized. The enzymes interact with hormones and signal transduction systems. The studies of intracellular, intercellular
V I, Kulinskiĭ, L S, Kolesnichenko
openaire +1 more source