Results 201 to 210 of about 18,229,039 (247)
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The glutathione system. I. Synthesis, transport, glutathione transferases, glutathione peroxidases
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, 2009Studies of glutathione system in all basic trends have been extended considerably during recent 10-15 years. A series of new metabolic enzymes has been discovered. Many of them are polyfunctional and their new activities have been recognized. The enzymes interact with hormones and signal transduction systems. The studies of intracellular, intercellular
V. I. Kulinsky, L. S. Kolesnichenko
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The glutathione system in Parkinson’s disease and its progression
Neuroscience & Biobehavioral Reviews, 2021Redox dysfunctions and neuro-oxidative stress play a major role in the pathophysiology and progression of Parkinson's disease (PD). Glutathione (GSH) and the reduced/oxidized glutathione (GSH/GSSG) ratio are lowered in oxidative stress conditions and may lead to increased oxidative toxicity.
Bjorklund, G +4 more
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Glutathione Transport System in NIH3T3 Fibroblasts
Molecular Cell Biology Research Communications, 2000The current study characterizes a mediated transport for GSH uptake in murine fibroblasts NIH3T3. The presence of GSH mediated transport is indicated by the behaviour of GSH uptake time-course, as well as by kinetic saturation and the specific inhibition of the initial rate of GSH transport. Moreover, a concentrative GSH uptake has been measured, whose
FAVILLI, FABIO +3 more
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The Glutathione System in Alkylator Resistance
2002One of the greatest obstacles in the effective chemotherapy of neoplastic disease is the presence of tumor chemoresistance. In some instances, a tumor can be intrinsically resistant to chemotherapy or, in other cases, develop resistance during the course of antineoplastic treatment.
David, Hamilton +2 more
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Antioxidants and Redox Signaling, 2017
Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there is a strong correlation between elevated levels
Nadine El Banna, Meng-Er Huang
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Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there is a strong correlation between elevated levels
Nadine El Banna, Meng-Er Huang
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Glutathione systems and anoxia tolerance in turtles
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1997Effects of anoxic submergence (20 h at 5 degrees C) and subsequent 24 h aerobic recovery on glutathione levels and the activities of glutathione-related enzymes were examined in six tissues of Trachemys scripta elegans. Anoxia exposure resulted in tissue-specific changes in enzyme maximal activities, the most dramatic being suppression of gamma ...
W G, Willmore, K B, Storey
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Clinical significance of the glutathione-conjugating system
Pharmacological Research Communications, 1983Glutathione displays important functions in living cells of many species, human included. Apart from its direct antioxidative activity, which supports the maintenance of the reduced state of proteinthiols, and its possible role in amino acid transport across membranes, it appears to exert several detoxification functions.
C P, Siegers, M, Younes
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Glutathione Metabolism and Some Possible Functions of Glutathione in the Nervous System
1976Publisher Summary Glutathione is the most ubiquitous peptide found in living cells. It plays an important role as a coenzyme in several enzymic reactions. The enzymic reactions of the synthesis and degradation of glutathione are linked in a cyclic process called “γ-glutamyl cycle.” The cycle functions in amino acid transport.
M, Orlowski, A, Karkowsky
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Linked thioredoxin-glutathione systems in platyhelminths
Trends in Parasitology, 2004The thioredoxin and glutathione systems play a central role in thiol-disulfide redox homeostasis in many organisms by providing electrons to essential enzymes, and defence against oxidative stress. These systems have recently been characterized in platyhelminth parasites, and the emerging biochemical scenario is the existence of linked processes with ...
Gustavo, Salinas +4 more
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The glutathione defense system in the pathogenesis of rheumatoid arthritis
Journal of Applied Toxicology, 2001AbstractIn order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (RA), serum reduced glutathione levels (GSH), glutathione reductase (GSR), glutathione S‐transferase (GST), glutathione peroxidase (GSH‐Px) and alkaline phosphatase (ALP) activities, lipid peroxidation (MDA content) and ...
M Q Hassan, S J Stohs
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