Results 41 to 50 of about 320,403 (261)

Thioredoxin and glutathione systems in Plasmodium falciparum

International Journal of Medical Microbiology, 2012
Despite a 50% decrease in malaria infections between 2000 and 2010, malaria is still one of the three leading infectious diseases with an estimated 216 million cases worldwide in 2010. More than 90% of all malaria infections were caused by Plasmodium falciparum, a unicellular eukaryotic parasite that faces oxidative stress challenges while developing ...
Esther, Jortzik, Katja, Becker
openaire   +2 more sources

The Glutathione System of Aspergillus nidulans Involves a Fungus-specific Glutathione S-Transferase [PDF]

Journal of Biological Chemistry, 2009
The tripeptide glutathione is involved in cellular defense mechanisms for xenobiotics and reactive oxygen species. This study investigated glutathione-dependent mechanisms in the model organism Aspergillus nidulans. A recombinant dimeric protein of A. nidulans glutathione reductase (GR) contained FAD and reduced oxidized glutathione (GSSG) using NADPH ...
Ikuo, Sato, Motoyuki, Shimizu, Takayuki, Hoshino, Naoki, Takaya   +3 more
openaire   +2 more sources

Systemic Glutathione as a Skin-Whitening Agent in Adult [PDF]

Dermatology Research and Practice, 2020
Objectives. To compare the efficacy and safety profiles of systemic glutathione as a skin-whitening agent in adults from several randomized controlled trials (RCTs). Methods. This study is an evidence-based case report with literature search conducted on Clinical Key, Cochrane, Journal of the American Academy of Dermatology, Taylor and Francis Online ...
I. B. S. Sitohang, S. Ninditya
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte [PDF]

FEBS Letters, 1998
Plasmodium falciparum parasites grew normally in glutathione (GSH)‐depleted normal and G6PD‐deficient (Mediterranean variant) erythrocytes (RBC). Growth inhibition was observed only at less than approximately 6–12% residual GSH. Parasites studied separately with the Sendai virus technique synthesized GSH de novo and regenerated reduced GSH 10–20 times
Ayi, Kodjo, Cappadoro, Marina, Branca, Mario, Turrini, Franco, Arese, Paolo   +4 more
openaire   +2 more sources

The modulatory action of taraxacum officinale on the glutathione system

Bulletin of the Academy of Sciences of Moldova. Medical Sciences, 2023
The evaluation of the antioxidant activity of plants has been an important issue taking into account its importance on human health. Natural antioxidants protec t cells against oxidative stress, which can damage the cellular components. Taraxacum officinale (TO) leaves (TOL) and roots (TOR) has been commonly used in traditional medicine due to ...
Ala Fulga, Svetlana Protopop, Lilia Andronache, Olga Tagadiuc   +3 more
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Long-Term Treatment with Low-Level Arsenite Induces Aberrant Proliferation and Migration via Redox Rebalance in Human Urothelial Cells

Cells
Chronic exposure to arsenic via drinking water can induce bladder cancer in humans. Nevertheless, there is little knowledge about the precise mechanisms of this.
Xiangli Yan, Qing Zhou, Shuhua Xi, Peiyu Jin   +3 more
doaj   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source