Results 21 to 30 of about 320,403 (261)

Thioredoxin and Glutathione Systems

, 2021
Most cancer cells contain high levels of reactive oxygen species (ROS), which result in higher expression levels of the glutathione and thioredoxin reductase systems. These antioxidant systems convert ROS to nonharmful compounds and they also reduce disulfide bonds in oxidized proteins.
Yu, Yezhou, Di Trapani, Giovanna, Tonissen, Kathryn   +2 more
openaire   +3 more sources

EFFECT OF N-ACETYLCYSTEINE ON APOPTOSIS OF P19 CANCER CELLS DURING HYPOXIA

Сибирский онкологический журнал, 2020
Introduction. Hypoxia in tumor growth contributes to mitochondrial dysfunction and exacerbates oxidative stress in the immortalized cell. The objective of the study was to investigate the molecular mechanisms of the effects of N-acetylcysteine on redox ...
O. L. Nosareva, D. S. Orlov, E. V. Shakhristova, E. A. Stepovaya, A. A. Sadykova   +4 more
doaj   +1 more source

Mitochondrial thiol-disulfide system under acute hypoxia and hypoxic-hyperoxic adaptation [PDF]

The Ukrainian Biochemical Journal, 2014
The authors investigated the state of mitochondrial glutathione pool (reduced and oxidized glutathione, protein-GSH mixed disulfides), content of carbonyl groups and free sulfhydryl groups of proteins, protein expression of key mitochondrial antioxidant ...
O. A. Gonchar, I. N. Mankovska
doaj   +1 more source

Glutathione System in Sleep Disorders (Literature Review)

Acta Biomedica Scientifica, 2021
This review examines the variability of the glutathione system in sleep pathologies. Modern sleep theory assumes a restorative sleep function, including active utilization of oxidants and protection from excessive oxidation.
A. S. Brichagina, N. V. Semenova, I. M. Madaeva   +2 more
doaj   +1 more source

Cell signalling and the glutathione redox system [PDF]

Biochemical Pharmacology, 2002
The reduction/oxidation (redox) state of the cell is a consequence of the balance between the levels of oxidising and reducing equivalents. A reducing intracellular environment is often associated with cell survival; however, redox unbalance is necessary since it represents a regulatory sensor for several nuclear transcription factors.
FILOMENI, GIUSEPPE, ROTILIO, GIUSEPPE, CIRIOLO, MARIA ROSA   +2 more
openaire   +3 more sources

Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases

Antioxidants, 2022
Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease.
Haseena P. A., Latha Diwakar, Vijayalakshmi Ravindranath   +2 more
doaj   +1 more source

Evaluation of Glutathione (GSH) System in Porcine Saliva: Validation and Application of Colorimetric Method

Antioxidants
(1) Reduced glutathione (GSH) is considered the first line of antioxidant defense. During oxidative stress, it is oxidized to glutathione disulphide (GSSG).
Gamze Gok, Salim Neselioglu, Heng-Lun Ko, Ozcan Erel, María José López-Martínez, Xavier Manteca, Camila Peres Rubio   +6 more
doaj   +1 more source

Diagnostic sensitivity and specificity of indicators of glutathione antioxidant system in spermatozoa of infertile men with different forms of pathospermia

Біологічні студії
Background. One of the most important antioxidant defence mechanism in spermatozoa is the gluthatione system which includes glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and reduced glutathione (GSH).
Zoryana Fedorovych, Mykola Vorobets, Olena Onufrovych, Оksana Melnyk, Natalia Gromnatska, Nataliya Lychkovska, Anna Besedina, Zinoviy Vorobets, Roman Fafula   +8 more
doaj   +1 more source

Balance of glutathione system activity in ascitic ovarian tumor under the experimental conditions

Journal of Education, Health and Sport
The article presents the experimental results of the investigation the glutathione system activity in rats simulated ovarian ascites tumor. It was found that the glutathione system in the form of glutathione reductase and glutathione peroxidase is ...
V. Sarakhan
doaj   +1 more source

THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO

Бюллетень сибирской медицины, 2015
The formation of oxidative stress lies at the heart of many frequent and socially-important diseases. Blood lymphocytes are the cells which provide immunological control of our organism.
O. L. Nosareva, Ye. A. Stepovaya, N. V. Ryazantseva, Ye. V. Shakhristova, O. N. Vesnina, V. V. Novitsky   +5 more
doaj   +1 more source