Results 21 to 30 of about 18,229,039 (247)

Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach [PDF]

, 2010
Oxidative stress is often associated to inactivity-mediated skeletal muscle atrophy. Glutathione is one of the major antioxidant systems stimulated, both at muscular and systemic level, by activation of oxidative processes.
DALLA LIBERA L, Francesco Agostini, Biolo, Gianni, JURDANA M, Mihaela Jurdana, Sara Mazzucco, BIOLO G., Agostini, Francesco, Jörn Rittweger, Mazzucco, Sara, Jurdana, Mihaela, Luciano Dalla Libera, Narici, Marco, Gianni Biolo, Dalla Libera, Luciano, NARICI M, MEKJAVIC IB, Rittweger, Jörn, AGOSTINI F, Igor B. Mekjavic, Pisot, Rado, PISOT R, Mekjavic, Igor, MAZZUCCO S, Gorza, Luisa, Rado Pišot, RITTWEGER J, Marco Narici, Luisa Gorza, Gorza L   +29 more
core   +1 more source

Effects of Panthenol and N-Acetylcysteine on Changes in the Redox State of Brain Mitochondria under Oxidative Stress In Vitro

Antioxidants, 2021
The glutathione system in the mitochondria of the brain plays an important role in maintaining the redox balance and thiol–disulfide homeostasis, whose violations are the important component of the biochemical shifts in neurodegenerative diseases ...
Dmitry S. Semenovich, Egor Yu. Plotnikov, Oksana V. Titko, Elena P. Lukiyenko, Nina P. Kanunnikova   +4 more
doaj   +1 more source

Thioredoxin and Glutathione Systems

, 2021
Most cancer cells contain high levels of reactive oxygen species (ROS), which result in higher expression levels of the glutathione and thioredoxin reductase systems. These antioxidant systems convert ROS to nonharmful compounds and they also reduce disulfide bonds in oxidized proteins.
Yu, Yezhou, Di Trapani, Giovanna, Tonissen, Kathryn   +2 more
openaire   +3 more sources

EFFECT OF N-ACETYLCYSTEINE ON APOPTOSIS OF P19 CANCER CELLS DURING HYPOXIA

Сибирский онкологический журнал, 2020
Introduction. Hypoxia in tumor growth contributes to mitochondrial dysfunction and exacerbates oxidative stress in the immortalized cell. The objective of the study was to investigate the molecular mechanisms of the effects of N-acetylcysteine on redox ...
O. L. Nosareva, D. S. Orlov, E. V. Shakhristova, E. A. Stepovaya, A. A. Sadykova   +4 more
doaj   +1 more source

Mitochondrial thiol-disulfide system under acute hypoxia and hypoxic-hyperoxic adaptation [PDF]

The Ukrainian Biochemical Journal, 2014
The authors investigated the state of mitochondrial glutathione pool (reduced and oxidized glutathione, protein-GSH mixed disulfides), content of carbonyl groups and free sulfhydryl groups of proteins, protein expression of key mitochondrial antioxidant ...
O. A. Gonchar, I. N. Mankovska
doaj   +1 more source

The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission [PDF]

, 2009
1Infection of red blood cells (RBC) subjects the malaria parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive oxygen species. Plasmodium spp.
Vega-Rodríguez Joel, Franke-Fayard Blandine, Coppens Isabelle, Waters Andrew P., Dinglasan, R.R., Andrew P. Waters, Joel Vega-Rodríguez, Rhoel R. Dinglasan, Jacobs-Lorena Marcelo, José F Rodríguez-Orengo, Jacobs-Lorena, M., Rodríguez-Orengo José F., Blandine Franke-Fayard, Chris J. Janse, Vega-Rodriguez, J., Isabelle Coppens, José F. Rodríguez-Orengo, Serrano Adelfa E., Adelfa E. Serrano, Janse, C.J., Serrano, A.E., Rhoel R Dinglasan, Prakash Srinivasan, Waters, A., Adelfa E Serrano, Marcelo Jacobs-Lorena, Pastrana-Mena Rebecca, Janse Chris J., Chris J Janse, Dinglasan Rhoel R., Rodriguez-Orengo, J.F., Srinivasan, P., Pastrana-Mena, R., Rebecca Pastrana-Mena, Franke-Fayard, B., Andrew P Waters   +35 more
core   +2 more sources

Cellular glutathione content in the organ of Corti and its role during ototoxicity. [PDF]

, 2015
Glutathione (GSH) is the major scavenger of reactive oxygen species (ROS) inside cells. We used live confocal imaging in order to clarify the role of GSH in the biology of the organ of Corti, the sensory epithelium of the cochlea, before, during and ...
Paromita Majumder, Majumder, P, Duchen, MR, Jonathan E. Gale, Michael R. Duchen, Gale, JE   +5 more
core   +1 more source

Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D [PDF]

, 2008
In the present study, we used a recombinant filamentous fungus strain, Aspergillus niger B1-D, as a model system, and investigated the antioxidant defences in this organism.
Li, Qiang, Harvey, L.M., Mcneil, Brian
core   +3 more sources

Cell signalling and the glutathione redox system [PDF]

Biochemical Pharmacology, 2002
The reduction/oxidation (redox) state of the cell is a consequence of the balance between the levels of oxidising and reducing equivalents. A reducing intracellular environment is often associated with cell survival; however, redox unbalance is necessary since it represents a regulatory sensor for several nuclear transcription factors.
FILOMENI, GIUSEPPE, ROTILIO, GIUSEPPE, CIRIOLO, MARIA ROSA   +2 more
openaire   +3 more sources

Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases

Antioxidants, 2022
Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease.
Haseena P. A., Latha Diwakar, Vijayalakshmi Ravindranath   +2 more
doaj   +1 more source