Versatility of Glutathione Transferase Proteins [PDF]
Biomolecules, 2023 For more than 60 years, glutathione transferases (GSTs) have attracted attention, but the research field of the GSTome [...]
Bengt Mannervik
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Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis [PDF]
Frontiers in Molecular Biosciences, 2021 Considering the pleiotropic roles of glutathione transferase (GST) omega class members in redox homeostasis, we hypothesized that polymorphisms in GSTO1 and GSTO2 might contribute to prostate cancer (PC) development and progression.
Veljko Santric +26 more
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Glutathione transferase P1 is modified by palmitate. [PDF]
PLoS ONEGlutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling.
Vanessa Marensi +5 more
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Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors. [PDF]
PLoS ONEMultidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR.
Ahmed Sabt +12 more
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Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase [PDF]
Antioxidants, 2022 Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic mutagens, and carcinogens.
Juan Segura-Aguilar +5 more
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Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer [PDF]
Medicina, 2022 Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug accumulation ...
Petar Simic +10 more
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The Activity of Antioxidant and Anaerobic Glycolysis Enzymes Under Thermal Gradient Exposure in Palearctic Species Lymnaea stagnalis [PDF]
Journal of Stress Physiology & Biochemistry, 2013 The aim of present study was the evaluation of antioxidant (peroxidase, catalase, glutathione S transferase) and anaerobic glycolysis (lactate dehydrogenase) enzymes activity under thermal gradient in Palearctic species Lymnaea stagnalis ...
Vereshchagina К.P. +8 more
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Glutathione Transferases [PDF]
The Arabidopsis Book, 2010 The 55 Arabidopsis glutathione transferases (GSTs) are, with one microsomal exception, a monophyletic group of soluble enzymes that can be divided into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR) and TCHQD classes. The populous phi and tau classes are often highly stress inducible and regularly crop up in proteomic and ...
David P, Dixon, Robert, Edwards
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Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942. [PDF]
, 2020 An excess of reactive oxygen species (ROS) can cause severe oxidative damage to cellular components in photosynthetic cells. Antioxidant systems, such as the glutathione (GSH) pools, regulate redox status in cells to guard against such damage ...
Beld, Joris +9 more
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Glutathione-binding site of a bombyx mori theta-class glutathione transferase. [PDF]
PLoS ONE, 2014 The glutathione transferase (GST) superfamily plays key roles in the detoxification of various xenobiotics. Here, we report the isolation and characterization of a silkworm protein belonging to a previously reported theta-class GST family.
M D Tofazzal Hossain +2 more
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