Versatility of Glutathione Transferase Proteins [PDF]
Biomolecules, 2023 For more than 60 years, glutathione transferases (GSTs) have attracted attention, but the research field of the GSTome [...]
Bengt Mannervik
doaj +2 more sources
Glutathione Transferases [PDF]
The Arabidopsis Book, 2010 The 55 Arabidopsis glutathione transferases (GSTs) are, with one microsomal exception, a monophyletic group of soluble enzymes that can be divided into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR) and TCHQD classes. The populous phi and tau classes are often highly stress inducible and regularly crop up in proteomic and ...
David P, Dixon, Robert, Edwards
semanticscholar +4 more sources
Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis [PDF]
Frontiers in Molecular Biosciences, 2021 Considering the pleiotropic roles of glutathione transferase (GST) omega class members in redox homeostasis, we hypothesized that polymorphisms in GSTO1 and GSTO2 might contribute to prostate cancer (PC) development and progression.
Veljko Santric +26 more
doaj +2 more sources
Does occupational exposure to solvents and pesticides in association with glutathione S-transferase A1, M1, P1, and T1 polymorphisms increase the risk of bladder cancer? The Belgrade case-control study. [PDF]
PLoS ONE, 2014 OBJECTIVE: We investigated the role of the glutathione S-transferase A1, M1, P1 and T1 gene polymorphisms and potential effect modification by occupational exposure to different chemicals in Serbian bladder cancer male patients.
Marija G Matic +8 more
doaj +2 more sources
Tumor Biology, 2017 One of the mechanisms for epigenetic silencing of tumor suppressor genes is hypermethylation of cytosine residue at CpG islands at their promoter region that contributes to malignant progression of tumor.
Umesh Kumar +2 more
doaj +2 more sources
Glutathione Transferase (GST)-Activated Prodrugs
Pharmaceutics, 2013 Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione.
Andrea Calderan, Paolo Ruzza
doaj +2 more sources
Glutathione transferase P1 is modified by palmitate. [PDF]
PLoS ONEGlutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling.
Vanessa Marensi +5 more
doaj +2 more sources
Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors. [PDF]
PLoS ONEMultidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR.
Ahmed Sabt +12 more
doaj +2 more sources
Glutathione S-Transferase Enzymes in Plant-Pathogen Interactions
Frontiers in Plant Science, 2018 Plant glutathione S-transferases (GSTs) are ubiquitous and multifunctional enzymes encoded by large gene families. A characteristic feature of GST genes is their high inducibility by a wide range of stress conditions including biotic stress.
Gábor Gullner +3 more
doaj +2 more sources
Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase [PDF]
Antioxidants, 2022 Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic mutagens, and carcinogens.
Juan Segura-Aguilar +5 more
doaj +2 more sources