Results 21 to 30 of about 428,300 (333)

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.

Cell Reports, 2019
The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis.
M. Hughes, Alexander Hooftman, Stefano Angiari, P. Tummala, Z. Zaslona, M. Runtsch, A. F. Mcgettrick, Caroline E. Sutton, C. Diskin, M. Rooke, Shuhei Takahashi, S. Sundararaj, M. Casarotto, J. Dahlstrom, E. Palsson-McDermott, S. Corr, K. Mills, R. Preston, N. Neamati, Yiyue Xie, J. Baell, P. Board, L. O’Neill   +22 more
semanticscholar   +1 more source

Low serum glutathione-S-transferase activity and vitamin e levels do not correlate with disease severity in steady state adults with sickle cell anemia

Journal of Applied Hematology, 2017
Introduction: Adequate levels of antioxidants are essential in subjects with sickle cell anaemia (SCA) to counter the effects reactive oxygen species generated during normal red cell metabolism.
Patrick O Manafa, Chide E Okocha, John C Aneke, Ujunwa Obiano, Nancy C Ibeh, George O Chukwuma, Vera I Manafa   +6 more
doaj   +1 more source

GPI-anchored glutathione S-transferase as marker allows affinity sorting of transfection-positive cells

Frontiers in Molecular Biosciences, 2022
Cell transfection efficiency is still a limiting factor in gene function research. A method that allows isolation and enrichment of the transfection-positive cells is an effective solution. Here, we report a transfection-positive cell sorting system that
Shumin Ma, Lele Yang, Qingqing Zuo, Qilai Huang   +3 more
doaj   +1 more source

Glutathione transferases in bacteria [PDF]

The FEBS Journal, 2008
Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are grouped into several classes. Bacterial GSTs are implicated in a variety of distinct processes such as the biodegradation of xenobiotics, protection against chemical and ...
ALLOCATI, Nerino, FEDERICI, Luca, MASULLI, Michele, DI ILIO, Carmine   +3 more
openaire   +2 more sources

Metabolism of hydroperoxy-phospholipids in human hepatoma HepG2 cells

Journal of Lipid Research, 1996
Two enzymatic mechanisms have been proposed for the metabolism of hydroperoxy-phospholipids: i) the combined action of phospholipase A2 and glutathione peroxidase, and/or ii) direct enzymatic reduction.
Y Bao, G Williamson
doaj   +1 more source

Nitric oxide-mediated effects of L-ornithine-L-aspartate in acute toxic liver injury [PDF]

Pharmacia, 2022
This study was aimed to investigate nitric oxide-dependent mechanisms of L-ornithine-L-aspartate (LOLA) action in acute toxic liver injury in rats.
Vitalij Datsko, Halyna Loi, Tamara Datsko, Alla Mudra, Anna Mykolenko, Tetyana Golovata, Mykhailo Furdela, Yurii Orel, Iryna Smachylo, Andrii Burak, Mykola Klantsa, Oleksandra Oleshchuk   +11 more
doaj   +3 more sources

THE STATE OF GLUTATHIONE SYSTEM IN RAT TISSUES WITH TRAUMA MUSCULOSKELETAL SYSTEM IN THE METHIONINE INDUCED HYPERHOMOCYSTEINEMIA

Медицинский вестник Юга России, 2015
Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of ...
I. A. Alliluev, E. M. Vechkanov, I. A. Sorokina, Ju. N. Kaljuzhnaja, A. V. Temjakov, I. I. Kuznecov, V. V. Vnukov   +6 more
doaj   +1 more source

Effect of atrazine on glutathione levels, glutathione s-transferase and glutathione reductase activities in pea and wheat plants

Plant Protection Science, 2004
Changes were studied in the endogenous level of glutathione (total and oxidised), and in the amount of free thiol groups as caused by the herbicide atrazine on two species of plants with different sensitivity to it.
Lyuba P.-E. Miteva, Sergei V. Ivanov, Vera S. Alexieva, Emanuil N. Karanov   +3 more
doaj   +1 more source

Identification of a diazinon-metabolizing glutathione S-transferase in the silkworm, Bombyx mori

Scientific Reports, 2016
The glutathione S-transferase superfamily play key roles in the metabolism of numerous xenobiotics. We report herein the identification and characterization of a novel glutathione S-transferase in the silkworm, Bombyx mori.
Kohji Yamamoto, N. Yamada
semanticscholar   +1 more source

Mapping of amino acid substitutions conferring herbicide resistance in wheat glutathione transferase.

ACS Synthetic Biology, 2015
We have used design of experiments (DOE) and systematic variance to efficiently explore glutathione transferase substrate specificities caused by amino acid substitutions.
S. Govindarajan, B. Mannervik, J. Silverman, Kath Wright, Drew D. Regitsky, Usama M Hegazy, T. J. Purcell, M. Welch, J. Minshull, C. Gustafsson   +9 more
semanticscholar   +1 more source