Results 71 to 80 of about 89,718 (303)

D-ribose in glycation and protein aggregation [PDF]

, 2012
Background: D-ribose is a naturally occurring pentose monosaccharide present in all living cells and their microenvironments and is a key component of numerous biomolecules involved in many important metabolic pathways.
Liu, Ying, Wei, Yan, Zhou, Jun, He, Rong Qiao, He, RQ (reprint author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, 15 Datun Rd, Beijing 100101, Peoples R China., Han, Chan Shuai, Chen, Lan   +6 more
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Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Estimation of oxidative stress markers: human advanced glycation end products and human advanced oxidation protein products in patients with atopic dermatitis

Journal of the Egyptian Women’s Dermatologic Society
Introduction Pathogenesis of atopic dermatitis (AD) is complex and includes several aspects, such as genetics and environmental exposure. Recently, several research studies have highlighted the effect of oxidative stress (OS) in different dermatological ...
Iman M. Abdelmeniem, Aliaa I. Ismail, Naglaa F. Agamia, Nesrine A. Helaly, Hassan Mamdouh, Mohamed H. AbouHadeed, Dalia I. Halwag   +6 more
doaj   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid

Molecules, 2020
The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties.
Agnieszka Szkudlarek, Michał Wilk, Małgorzata Maciążek-Jurczyk   +2 more
doaj   +1 more source

Glycation inhibition assay.

, 2018
Glycation inhibition assay.
Edson Lucas dos Santos (135386), Emerson Silva Lima (709674), Kely de Picoli Souza (662430), Valter Vieira Alves Junior (5340938), Jéssica Maurino dos Santos (5340941), Luiza Antas Rabelo (662429), Ana Paula de Araújo Boleti (5095457), Carlos Alexandre Carollo (552174), Janielle da Silva Melo da Cunha (5340944), Tamaeh Monteiro Alfredo (5340935)   +9 more
core   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition

Gut Microbes, 2020
This study aimed to investigate the effects of glycated milk casein (Gc) fermented with Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and behavioral properties in mice under chronic stress. Mice were administered Gc or
Nam Su Oh, Jae Yeon Joung, Ji Young Lee, Jae Gwang Song, Sangnam Oh, Younghoon Kim, Hyung Wook Kim, Sae Hun Kim   +7 more
doaj   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

Effect of protein glycation by methylglyoxal on pancreatic beta cell function [PDF]

Methylglyoxal is a physiological dicarbonyl metabolite and potent argininedirected glycating agent. It often modifies proteins at functional sites producing loss of positive charge, structural distortion and inactivation.
Tym, Amy
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