Results 51 to 60 of about 89,718 (303)
Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu +20 morewiley +1 more sourcePathological Significance of Mitochondrial Glycation
, 2012 Glycation, the nonenzymatic glycosylation of biomolecules, is commonly observed in diabetes and ageing. Reactive dicarbonyl species such as methylglyoxal and glyoxal are thought to be major physiological precursors of glycation. Because these dicarbonyls Michael P. Murphy, Pamela Boon Li Puncore +1 more sourceInsights into the molecular mechanism of protein native-like aggregation upon glycation [PDF]
, 2013 Several human neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Familial Amyloidotic Polyneuropathy, have long been associated with, structural and functional changes in disease related proteins leading to aggregation into ...Oliveira, Luís M. A., Phoenix, David Andrew, Quintas, Alexandre, Lages, Ana, Coelho, Ana V., Gomes, Ricardo A., Família, Carlos, Murphy, Regina M., Oliveira, Luis M.A., Yang, Dennis, Dennison, Sarah Rachel +10 morecore +1 more sourceGut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression
Advanced Science, EarlyView.Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv +12 morewiley +1 more sourceAnti-glycation agent comprising a Garcinia kola extract or fraction [PDF]
, 2014 This invention relates to an anti-glycation agent comprising a Garcinia kola extract or fraction. The compositions comprising the extract or the fraction are used to inhibit the glycation of proteins, in particular the glycation of skin proteins involved P. Richomme, K. Touré, S. Derbré, Derbré, Séverine, Touré, Kaatio, Richomme, Pascal, S. Morel, Morel, Sylvie +7 morecore +2 more sourcesIntegrated assessment of phytochemicals, Antilipase, hemoglobin antiglycation, antihyperglycemic, antifungal and antibacterial properties of vetiveria zizanioides (L.) Nash
International Journal of Food PropertiesVetiveria zizanioides, known as vetiver grass, is renowned for its ecological significance in soil erosion control and the restoration of lands polluted by heavy metals.Fahd Kandsi, Rhizlan Abdnim, Nesrine Benkhaira, Fatima Zahra Lafdil, Mohamed Bnouham, Boutaina Yamani, Hanae Naceiri Mrabti, Gezahign Fentahun Wondmie, Yousef A. Bin Jardan, Samir Ibenmoussa, Naoufal El Hachlafi +10 moredoaj +1 more sourceInsights on glycated albumin
Annales de Biologie Clinique, 2019 Like all proteins, plasma albumin can undergo glycation to produce glycated albumin. This glycation will change the structure and therefore functionalities of albumin. Because of its accessibility, its high concentration and its half-life the glycation of albumin is greater than that of haemoglobin.Anne, Hay-Lombardie, Saïd, Kamel, Edith, Bigot-Corbel +2 moreopenaire +3 more sourcesGlycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies
, 2017 α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of ...Oliveira, Luís M. A., Luisa V. Lopes (4181968), Francesca Munar (7744001), Oliveira, M., Gomes, Marcos A, Hugo Vicente Miranda, Irina Zamolo, Vicente Miranda, Hugo, Santos, N., Thomas M. Jovin, Zamolo, I., Luı´s M. A. Oliveira (7743983), Tania Simoes (7744004), Zweckstetter, Markus, Hilal A. Lashuel (261037), de Oliveira, Rita M, Markus Zweckstetter, Martins, Ivo C, Nuno C. Santos (354057), Martins, I., Engelender, S., Ana Ponces-Freire, Ponces-Freire, Ana, Francisco J. Enguita (261452), Ruth Rott (7743995), Simone Engelender (7744016), Breda, C., Hugo Vicente Miranda (3812248), Oliveira, L., Simões, Tânia, Rita M. de Oliveira, Olaf Riess (110686), Hilal A. Lashuel, Enguita, F., Carlos Cordeiro (279493), Alexandre Quintas (232621), Gomes, M., Francesca Munari, Wei Xiang, Marcos A. Gomes (7743992), Klucken, J., Luís M. A. Oliveira, Szego, Éva M., Klucken, Jochen, Simoes, T., Santos, Nuno C, Ivo C. Martins (1651531), Xiang, W., Miranda, H., Jochen Klucken (335764), Carlo Breda (5076125), Carlos Cordeiro, Simone Engelender, Riess, Olaf, de Oliveira, Rita M., Ekrem Darendelioglu, Oliveira, Luís M.A., Michael Heinrich, Enguita, Francisco Javier, Outeiro, Tiago F., Carlo Breda, Francisco J. Enguita, Breda, Carlo, Outeiro, Tiago F, de Oliveira, Rita Machado, Ferreira, Diana G, Szego, E., Ekrem Darendelioglu (7743986), Xiang, Wei, Zweckstetter, M., Luisa V. Lopes, Lashuel, Hilal A, Lopes, Luisa V., Outeiro, T., Lashuel, Hilal Ahmed, Flaviano Giorgini, Rita M. de Oliveira (7743989), Oliveira, Márcia, Ma´rcia Oliveira (7743998), Enguita, Francisco J, Munari, Francesca, Eva F. Rodrigues, Deborah Penque (2365399), Diana G. Ferreira, Eva F. Rodrigues (7744007), Ruth Rott, Zamolo, Irina, Jovin, Thomas M, Diana G. Ferreira (4006694), Rodrigues, E., Penque, D., Quintas, A., Lopes, L., Alexandre Quintas, Irina Zamolo (7744010), Nuno C. Santos, Giorgini, Flaviano, Outeiro, Tiago Fleming, Ferreira, D., Flaviano Giorgini (58325), Szego, Éva M, Thomas M. Jovin (9674), Ivo C. Martins, Martins, Ivo C., Ana Ponces-Freire (7744013), Wei Xiang (46368), Miranda, Hugo Vicente, Oliveira, Luís M A, Darendelioglu, Ekrem, Marcos A. Gomes, Rodrigues, Eva F., Ponces-Freire, A., Tânia Simões, Jovin, T., Quintas, Alexandre, E´ va M. Szego (7743980), Riess, O., Oliveira, Rita M. de, Penque, Deborah, Lashuel, H., Enguita, Francisco J., Freire, Ana Ponces, Rodrigues, Eva F, Lopes, Luisa V, de Oliveira, R., Cordeiro, C., Markus Zweckstetter (133481), Cordeiro, Carlos, Deborah Penque, Munari, F., Engelender, Simone, Éva M. Szegő, Jochen Klucken, Jovin, Thomas M., Lopes, Luisa Vaqueiro, Gomes, Marcos Antonio, Darendelioglu, E., Ferreira, Diana G., Heinrich, Michael, Santos, Nuno C., Márcia Oliveira, Giorgini, F., Tiago F. Outeiro (191379), Rott, Ruth, Tiago F. Outeiro, Lashuel, Hilal A., Gomes, Marcos A., Michael Heinrich (1375335), Rott, R., Olaf Riess, Vincente Miranda, H., Heinrich, M., Oliveira, R., Jovin TM, Enguita FJ, Ferreira DG, Gomes MA, Martins IC, Zweckstetter M, Penque D, Zamolo I, Szego ÉM, Lashuel HA, de Oliveira RM, Quintas A, Klucken J, Outeiro TF, Vicente Miranda H, Cordeiro C, Breda C, Darendelioglu E, Santos NC, Engelender S, Simões T, Lopes LV, Ponces-Freire A, Munari F, Riess O, Rott R, Oliveira LMA, Heinrich M, Rodrigues EF, Oliveira M, Xiang W, Giorgini F +184 morecore +1 more source
