Results 81 to 90 of about 134,228 (341)
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
core +3 more sources
Journal of the Egyptian Women’s Dermatologic SocietyIntroduction Pathogenesis of atopic dermatitis (AD) is complex and includes several aspects, such as genetics and environmental exposure. Recently, several research studies have highlighted the effect of oxidative stress (OS) in different dermatological ...
Iman M. Abdelmeniem +6 more
doaj +1 more source
Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Molecules, 2020 The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties.
Agnieszka Szkudlarek +2 more
doaj +1 more source
Could AGEs be markers of pre-eclampsia? Study of concentration of advanced protein glycation products in pregnant women with physiological pregnancy and pregnancy complicated with pre-eclampsia [PDF]
, 2022 Piotr Bodzek +4 more
openalex +1 more source
Advanced Science, EarlyView.Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma +15 more
wiley +1 more source
PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. [PDF]
, 2014 Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often ...
Abbott, Nicholas +11 more
core +2 more sources
Gut Microbes, 2020 This study aimed to investigate the effects of glycated milk casein (Gc) fermented with Lactobacillus rhamnosus 4B15 (FGc) on the intestinal microbiota and physiological and behavioral properties in mice under chronic stress. Mice were administered Gc or
Nam Su Oh +7 more
doaj +1 more source
Nanoceria Prevents Glucose-Induced Protein Glycation in Eye Lens Cells [PDF]
, 2021 Belal I. Hanafy +3 more
openalex +1 more source