Results 91 to 100 of about 44,199 (236)

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming

Molecular Nutrition &Food Research, EarlyView.
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri   +13 more
wiley   +1 more source

Dietary Consumption of Type 2 Resistant Starch and d‐Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High‐Fat Diet

Molecular Nutrition &Food Research, EarlyView.
This study compared the preventive effects of dietary resistant starch (RS2) from maize and d‐fagomine (FG) from buckwheat on cardiometabolic risk factors in high‐fat (HF) diet‐fed rats. Wistar‐Kyoto rats (n = 11–12/group) received STD, HF, HF + RS, or HF + FG diets for 10 weeks.
Bernat Miralles‐Pérez, Sara Ramos‐Romero, María José Charpentier, Vanessa Sánchez‐Martos, Àngels Fortuño‐Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol‐Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu   +10 more
wiley   +1 more source

Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes

Molecular Nutrition &Food Research, EarlyView.
Sulfated polysaccharides from red seaweed improved testicular FSH and insulin signaling, which upregulated GLUT4 level and improved glycolysis and energy metabolism in testes of diabetic rats. ABSTRACT Testicular glucose homeostasis plays important roles in testicular energy metabolism and male fertility, but it is altered in type 2 diabetes (T2D ...
Ochuko L. Erukainure, Tosin A. Olasehinde, Olanrewaju S. Olayeriju, Bukola Omotoso, Md. Shahidul Islam, Ademola O. Olaniran   +5 more
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Effects of advanced glycation end products on stem cell

Frontiers in Cell and Developmental Biology
In recent years, stem cell therapy has become a pivotal component of regenerative medicine. Stem cells, characterized by their self-renewal capacity and multidirectional differentiation potential, can be isolated from a variety of biological tissues ...
Zetai Zheng, Hui Zhou, Wenwen Zhang, Tingyu Wang, Sathiskumar Swamiappan, Xinsheng Peng, Yanfang Zhou   +6 more
doaj   +1 more source

Association between dietary preferences and asthma among first‐grade primary school children

Pediatric Investigation, EarlyView.
The relationship between dietary habits and childhood asthma is an important area of research. Our results highlight the significance of a healthy diet in the management of children's health, particularly in the prevention of asthma. Schools and families should prioritize providing a balanced and nutritious diet to promote the overall health of ...
Xinyue Zhang, Xiaosa Wen, Tao Liu, Yongquan Yu, Liujie Zhu, Yingzi Chen, Dan Yu, Su Xu, Zengliang Ruan   +8 more
wiley   +1 more source

A Comparison of Emotionally Stimulated and Conventionally Collected Tears Using Bottom‐Up, Label‐Free Quantitative Proteomic Analysis—A Pilot Study

PROTEOMICS – Clinical Applications, EarlyView.
ABSTRACT Proteomic analysis of biofluids is central for identifying disease biomarkers. Tears have become popular targets for biomarker discovery and biosensor development, largely because they can be collected noninvasively and are rich sources of biomarkers for ocular and systemic diseases. Although basal and reflex tears have been well characterized,
Campbell Bruce Mousseau, Alena R. Veigl‐Lunsford, Rhonda L. Pitsch, Sean W. Harshman   +3 more
wiley   +1 more source

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao, Yunhua Liu, Kun Li, Lin Liu, Yanmo Cai, Xinxue Zhang, Zongjiang Zhao   +6 more
wiley   +1 more source

Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases

Small Science, EarlyView.
This review analyzes immunomodulatory biomaterial strategies for treating chronic inflammatory disorders in bone and soft tissues. It explores emerging mechanisms for resolving inflammation while promoting tissue regeneration, offering insights for developing targeted immunotherapeutic approaches that bridge material science with immunology for ...
Yiming Li, Xudong Xie, Chong Ding, Shengming Zhang, Liangcong Hu, Bobin Mi, Mengfei Liu, Guohui Liu   +7 more
wiley   +1 more source

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS

Aging Cell, EarlyView.
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann, Christina Haß, Muriel Knobloch, Israel Barrantes, Laura Fumagalli, Jessie Premereur, Franz Markert, Maite Peters, Georgia Koromila, Alexander Hartmann, Kathrin Jäger, Jette Abel, Renzo Mancuso, Alexander Storch, Michael Walter, Georg Fuellen, Andreas Hermann   +16 more
wiley   +1 more source