Results 41 to 50 of about 8,152,704 (249)

Advanced glycation end products

, 2022
Advanced glycation end products (AGEs) are a heterogeneous group of compounds formed by non-enzymatic interactions between the carbonyl groups of reducing sugars and free amino groups of proteins, lipids, or nucleic acids.
Dat, Pham Thai
core  

Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review

International Archives of Otorhinolaryngology, 2016
Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced ...
Austin Nguyen, Sheila Bhavsar, Erinn Riley, Gabriel Caponetti, Devendra Agrawal   +4 more
doaj   +1 more source

Magnolol ameliorates the accumulation of reactive oxidative stress and inflammation in diabetic periodontitis

Journal of the Formosan Medical Association, 2021
Background/Purpose: Periodontal disease and diabetes mellitus (DM) are both chronic inflammatory and highly prevalent diseases. A large amount of evidence suggested that the accumulation of oxidative stress plays a significant role in the deterioration ...
Chia-Ming Liu, Szu-Han Chen, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Pei-Ling Hsieh   +5 more
doaj   +1 more source

Advanced glycation end products and diabetic retinopathy [PDF]

Journal of Ocular Biology, Diseases, and Informatics, 2012
Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy.
Yashodhara, Sharma, Sandeep, Saxena, Arvind, Mishra, Anita, Saxena, Shankar Madhav, Natu   +4 more
openaire   +2 more sources

Advanced Glycation End-products and Atherosclerosis

Annals of Medicine, 1996
The late rearrangements of the covalent nonenzymatic modification of proteins by glucose, called advanced glycation end-products (AGEs), have been shown to accumulate in diabetic and ageing tissues. AGEs elicit a wide range of cell-mediated responses leading to vascular dysfunction, matrix expansion and athero- and glomerulosclerosis.
openaire   +2 more sources

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]

, 2014
The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila, Brownlee, M., Geoffrion, M., Courville, K., Du, X., Irshad, Zehra, Vanderhyden, B. C., Ott-Braschi, S., Sui, G., Thornalley, Paul J., Milne, R. W., D'Agati, V. D.   +11 more
core   +1 more source

Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development

, 2022
Type 1 diabetes (T1D) is an autoimmune disease in which the β-cells of the pancreas are attacked by the host’s immune system, ultimately resulting in hyperglycemia. It is a complex multifactorial disease postulated to result from a combination
Rani O. Whiddett, Whiddett, Rani O., Fotheringham, Amelia K, Chenping Du, Whiddett, Rani O, Chen Chen, Josephine M. Forbes, Du, Chenping, Chen, Chen, Buckle, Irina, Forbes, Josephine M, Fotheringham, Amelia K., Forbes, Josephine M., Irina Buckle, Amelia K. Fotheringham   +14 more
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +2 more sources

Polymorphisms of the receptor for advanced glycation end products and glyoxalase I and long-term outcome in patients with breast cancer

Tumor Biology, 2017
Receptor for advanced glycation end products and glyoxalase I metabolizing advanced glycation end product precursors may play important role in the pathogenesis and progression of cancer.
Petra Tesarova, Tomas Zima, Ales A Kubena, Marta Kalousova   +3 more
doaj   +1 more source