Results 51 to 60 of about 8,152,704 (249)

Evaluation of the AGE/sRAGE Axis in Patients with Multiple Myeloma

Antioxidants, 2019
Glycative stress influences tumor progression. The aim of the present study was to evaluate the advanced glycation end products/soluble receptor of advanced glycation end products (AGE/sRAGE) axis in patients with multiple myeloma (MM).
Alessandro Allegra, Caterina Musolino, Elisabetta Pace, Vanessa Innao, Eleonora Di Salvo, Maria Ferraro, Marco Casciaro, Giovanna Spatari, Gennaro Tartarisco, Andrea Gaetano Allegra, Sebastiano Gangemi   +10 more
doaj   +1 more source

Pyridoxamine ameliorates the effects of advanced glycation end products on subtotal nephrectomy induced chronic renal failure rats

, 2014
Advanced glycation end products (AGEs) contribute to the pathogenesis of renal diseases and have become a new therapeutic target for treatment. Chronic renal failure (CRF) is the end-stage of chronic renal diseases and highly associated with increased ...
Chuang, Yao-Chen;Wu, Ming-Shiou;Wu, Tai-Hsien;Su, Yi-Kai;Lee, Yi-Min, 吳明修   +1 more
core   +1 more source

Both Ca2+ and Zn2+ are essential for S100A12 protein oligomerization and function [PDF]

, 2009
Background Human S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins that are associated with many diseases including cancer, chronic inflammation and neurological disorders.
Lednev, Igor K., Helmut Wittkowski, Anatoli Ianoul, Igor B Bronstein, Shekhtman, Alexander, Bjoerk, Per, Alexander Shekhtman, Per Bjoerk, Foell, Dirk, Wei He, Igor K Lednev, Olga V Moroz, He, Wei, Burkitt, William I., Xie, Jingjing, Derrick, Peter J., Bronstein, Igor B., Vera Novitskaya, Polyakova, Oxana, Ianoul, Anatoli, Dirk Foell, Will Burkitt, Oxana Polyakova, Moroz, Olga V., Peter J Derrick, Wittkowski, Helmut, Novitskaya, Vera, Jingjing Xie   +27 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Increased concentration of two different advanced glycation end-products detected by enzyme immunoassays with new monoclonal antibodies in sera of patients with rheumatoid arthritis

BMC Musculoskeletal Disorders, 2010
Background Levels of pentosidine (representative of advanced glycation end-products) in sera of patients with rheumatoid arthritis are increased when compared with sera of other diagnoses or healthy controls.
Vilím Vladimír, Šedová Liliana, Vytášek Richard   +2 more
doaj   +1 more source

Impact of intracellular toxic advanced glycation end-products (TAGE) on murine myoblast cell death

Diabetology & Metabolic Syndrome, 2020
Background Sarcopenia is a progressive condition that is characterized by decreases in skeletal muscle mass and function. Although sarcopenia is associated with lifestyle-related diseases (LSRD), the mechanisms underlying cell death in myoblasts, which ...
Takanobu Takata, Akiko Sakasai-Sakai, Masayoshi Takeuchi   +2 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Advanced Glycation End Products in Clinical Nephrology

Kidney and Blood Pressure Research, 2004
As a result of oxidative and carbonyl stress, advanced glycation end products (AGEs) are involved in the pathogenesis of severe and frequent diseases and their fatal vascular/cardiovascular complications, i.e. diabetes mellitus and its complications (nephropathy, angiopathy, neuropathy and retinopathy, renal failure and uremic and dialysis-associated ...
M, Kalousová, T, Zima, V, Tesar, S, Stípek, S, Sulková   +4 more
openaire   +2 more sources

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes [PDF]

, 2015
Background The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of diabetic complications, and soluble forms of the receptor (sRAGE) can counteract the detrimental action of the full-length receptor by acting as ...
Wong, Y, Lee, ACH, Betteridge, DJ, Tan, KCB, Lam, JKY, Shiu, SWM   +5 more
core   +1 more source