Results 41 to 50 of about 10,069 (220)

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism

Frontiers in Immunology
ObjectiveTo identify serum lipid biomarkers for acute pulmonary embolism (APE) and evaluate their diagnostic value, and to investigate the impact of glycerol monolaurate (GML) and glycerol monooleate (GMO) on cytotoxic T cell function.MethodsA total of ...
Tongyao Guo, Tongyao Guo, Weibo Gao, Aimin Zhang, Dong Wang, Yushang Zhao, Yining Li, Zhihong Yue, Lin Pei, Mei Jia, Chen Liu, Lin-Lin Cao   +11 more
doaj   +1 more source

Biosynthesis of food constituents: Lipids. 2. Triacylglycerols, glycerophospholipids, and glyceroglycolipids - a review

Czech Journal of Food Sciences, 2006
This review article gives a survey of the principal biosynthetic pathways that lead to the most important food glycerolipids, i.e. triacylglycerols, glycerophospholipids, and glyceroglycolipids as reported in recently published papers ...
Jan Velíšek, Karel Cejpek
doaj   +1 more source

Lipid Players of Cellular Senescence

Metabolites, 2020
Lipids are emerging as key players of senescence. Here, we review the exciting new findings on the diverse roles of lipids in cellular senescence, most of which are enabled by the advancements in omics approaches.
Alec Millner, G. Ekin Atilla-Gokcumen
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Targeted and Untargeted Lipidomics of Emiliania huxleyi Viral Infection and Life Cycle Phases Highlights Molecular Biomarkers of Infection, Susceptibility, and Ploidy

Frontiers in Marine Science, 2015
Marine viruses that infect phytoplankton strongly influence the ecology and evolution of their hosts. Emiliania huxleyi is characterized by a biphasic life cycle composed of a diploid (2N) and haploid (1N) phase; diploid cells are susceptible to ...
Jonathan Eliott Hunter, Jonathan Eliott Hunter, Miguel J Frada, Helen F Fredricks, Assaf eVardi, Benjamin eVan Mooy   +5 more
doaj   +1 more source

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Antiviral Activity of the Marine Haptophyta Diacronema lutheri

Marine Drugs
There are still several viral infections affecting a considerable number of the world’s population, causing thousands of deaths each year. There are no drugs available for most viral infections and for many not even a vaccine.
Eleonora Montuori, Annalisa Ambrosino, Gerardo Della Sala, Costanza Ragozzino, Gianluigi Franci, Carla Zannella, Anna De Filippis, Donatella de Pascale, Massimiliano Galdiero, Chiara Lauritano   +9 more
doaj   +1 more source

Lipid composition of chloroplasts isolated by aqueous and nonaqueous techniques

Journal of Lipid Research, 1968
Chloroplasts isolated from tobacco leaves in 0.5 m sucrose solution (the 1000 g pellet) contained 83% of the total cellular monogalactosyl diglyceride, 88% of the digalactosyl diglyceride, 76% of the sulfolipid, and 74% of the phosphatidyl glycerol ...
Alpaslan Ongun, W.W. Thomson, J.B. Mudd
doaj   +1 more source