Results 51 to 60 of about 10,069 (220)

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

Neutral lipid storage disease: a genetic disorder with abnormalities in the regulation of phospholipid metabolism

Journal of Lipid Research, 1998
Neutral lipid storage disease (NLSD) is an autosomal recessive disorder characterized by the presence of numerous lipid droplets in virtually all tissues examined.
R. Ariel Igal, Rosalind A. Coleman
doaj   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Determination of Fatty Acid Methyl Esters Derived from Algae Scenedesmus dimorphus Biomass by GC-MS with One-step Esterification of Free Fatty Acids and Transesterification of Glycerolipids [PDF]

, 2017
Algae can synthesize, accumulate and store large amounts of lipids in its cells, which holds immense potential as a renewable source of biodiesel.
Xu, Yan, Avula, Satya Girish Chandra, Satya Girish Chandra Avula, Joanne M. Belovich, Belovich, Joanne M., Yan Xu   +5 more
core   +1 more source

Remarkable functions of sn-3 hydroxy and phosphocholine groups in 1,2-diacyl-sn-glycerolipids to induce clockwise (+)-helicity around the 1,2-diacyl moiety: Evidence from conformation analysis by 1H NMR spectroscopy

Beilstein Journal of Organic Chemistry, 2017
Cell-membrane glycerolipids exhibit a common structural backbone of asymmetric 1,2-diacyl-sn-glycerol bearing polar head groups in the sn-3 position. In this study, the possible effects of sn-3 head groups on the helical conformational property around ...
Yoshihiro Nishida, Mengfei Yuan, Kazuo Fukuda, Kaito Fujisawa, Hirofumi Dohi, Hirotaka Uzawa   +5 more
doaj   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Keeping It Native: Non‐Denaturing Approaches to Top‐Down Protein Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics and top‐down mass spectrometry approaches provide direct characterization of proteoforms; the specific molecular forms of proteins, including post‐translational modifications, truncations, alternative splicing, and sequence variants.
Michael Xiao, Edvaldo Vasconcelos Soares Maciel, Frederik Lermyte, Owen S. Skinner   +3 more
wiley   +1 more source

Chiral separation of glycerolipids by high-performance liquid chromatography [PDF]

, 2012
Since the enantiomer resolution of synthetic mono- and diacylglycerols as 3,5-dinitrophenylurethanes was achieved by chiral-phase high-performance liquid chromatography (HPLC) in the 1980s, the methodology has been extended to the resolution of various ...
Itabashi, Yutaka
core   +1 more source

Linoleic acid (18:2, N6) containing lipids were increased (blue highlight) in plasma phospholipids (PC, PI, LPE) of SAMS patients while only 2 glycerolipids (TGs) containing 18:2 were decreased (orange highlight) (TG 16:1_18:2_20:4 and TG 18:2_18:2_20:2).

, 2023
Linoleic acid (18:2, N6) containing lipids were increased (blue highlight) in plasma phospholipids (PC, PI, LPE) of SAMS patients while only 2 glycerolipids (TGs) containing 18:2 were decreased (orange highlight) (TG 16:1_18:2_20:4 and TG 18:2_18:2_20:2).
Claire L. Simpson (14951490), Joy Guingab (542835), Timothy J. Garrett (7418819), Gregory Farage (11013878), Rajendra Raghow (4330738), Saunak Sen (156466), Michelle A. Puchowicz (1991425), Logan M. Buchanan (17655859), Marshall B. Elam (4330747), Richard Childress (17655853), Elizabeth C. Brogdon (17655856), Edwards A. Park (17655850), Qingming Dong (5734967)   +12 more
core   +1 more source

Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy

Phytotherapy Research, EarlyView.
This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li, Mengyu Li, Shujing Liu, Yuan Wei, Chen Wang   +4 more
wiley   +1 more source