Results 91 to 100 of about 26,416 (261)

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Type I IFN induces long-chain acyl-CoA synthetase 1 to generate a phosphatidic acid reservoir for lipotoxic saturated fatty acids

Journal of Lipid Research
Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no consensus exists on why ACSL1 is induced by inflammatory ...
Shelley Barnhart, Masami Shimizu-Albergine, Eyal Kedar, Vishal Kothari, Baohai Shao, Melissa Krueger, Cheng-Chieh Hsu, Jingjing Tang, Jenny E. Kanter, Farah Kramer, Danijel Djukovic, Vadim Pascua, Yueh-Ming Loo, Lucrezia Colonna, Sadie J. Van den Bogaerde, Jie An, Michael Gale, Jr., Karen Reue, Edward A. Fisher, Sina A. Gharib, Keith B. Elkon, Karin E. Bornfeldt   +21 more
doaj   +1 more source

Diet-sourced carbon-based nanoparticles induce lipid alterations in tissues of zebrafish (Danio rerio) with genomic hypermethylation changes in brain [PDF]

, 2016
With rising environmental levels of carbon-based nanoparticles (CBNs), there is an urgent need to develop an understanding of their biological effects in order to generate appropriate risk assessment strategies.
Bedia, Eva Gorrochategui, Francis L. Martin, Guang-Guo Ying, Heqing Shen, Junyi Li, Li Cui, Meiping Tian, Mirbahai, Nigel J. Fullwood, Romà Tauler, Sílvia Lacorte, Vandegehuchte   +12 more
core   +1 more source

Genetic differentiation and adaptive evolution of buff‐tailed bumblebees in Asia

Insect Science, EarlyView.
This study investigates the genetic differentiation and local adaptation of the buff‐tailed bumblebee (Bombus terrestris) across its European and Asian populations. Using whole‐genome resequencing, we identified distinct genetic differences between populations, with Asian B. terrestris representing a unique genetic resource.
Long Su, Lele Ding, Paul H. Williams, Yan Liu, Ruijuan Wang, Xiaoyan Dai, Shan Zhao, Haolin Fu, Xiaomeng Zhao, Quangui Wang, Yancan Li, Huiling Sang, Robert M. Waterhouse, Yifan Zhai, Cheng Sun   +14 more
wiley   +1 more source

Functional characterization of TMEM86A and TMEM86B mutants by a novel lysoplasmalogenase assay

Journal of Lipid Research
: Plasmalogens are an abundant class of glycero-phospholipids with a characteristic 1-O-alk-1′-enyl double bond. While their synthesis has been extensively investigated, their degradation remains understudied. Plasmalogen deficiencies are associated with
Denise Kummer, Ilaria Dorigatti, Theresia Dunzendorfer-Matt, Georg Golderer, Ernst R. Werner, Katrin Watschinger   +5 more
doaj   +1 more source

Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption-ionization-mass spectrometry imaging (MALDI-MSI). [PDF]

, 2018
Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) to identify lipids directly involved as potential biomarkers ...
Amen, Beldon, Cajka, Choi, Evans, Fernandis, Gosain, Guest, Guo, Jiang, Koh, Korting, Larjava, McDaniel, Morgan, Nagai, Sasso, Schwamborn, Sen, Stephenson, Thomsen, Tsuji, Yang, Yin   +23 more
core   +2 more sources

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures

Biomolecules
Hepatocellular carcinoma (HCC), the most common primary liver malignancy, usually develops in patients with cirrhosis, yet the metabolic mechanisms that distinguish the two conditions remain poorly understood.
Cristina-Paula Ursu, Luminița Elena Furcea, Bogdan Procopeț, Răzvan Alexandru Ciocan, Ștefan Ursu, Claudia Diana Gherman, Dan Vălean, Rodica Sorina Pop, Emil Ioan Moiș, Horia Ștefănescu, Carmen Socaciu, Nadim Al Hajjar, Florin Graur   +12 more
doaj   +1 more source

Cues from the Membrane: Bacterial Glycerophospholipids [PDF]

Journal of Bacteriology, 2017
ABSTRACT In this issue of the Journal of Bacteriology , V. W. Rowlett et al. unveil new Escherichia coli circuitry linking membrane glycerophospholipid (GPL) homeostasis to bacterial stress response and adaptation mechanisms (J Bacteriol 199:e00849-16, 2017, https://doi ...
openaire   +2 more sources

Utilizing Thiocholesterol As A Hydrophobic Probe To Characterize Lipid Phase Behaviour [PDF]

, 2017
Lipid seperti sfingomielin, gliserofosfolipik dan kolesterol merupakan komponen utama yang membentuk serta mengekalkan kestabilan dan dinamik membran plasma eukariotik Lipids, such as sphingomyelins, glycero-phospholipids and cholesterol, represent ...
Lee, Yan Fen
core