Results 91 to 100 of about 20,599 (278)

Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures

Biomolecules
Hepatocellular carcinoma (HCC), the most common primary liver malignancy, usually develops in patients with cirrhosis, yet the metabolic mechanisms that distinguish the two conditions remain poorly understood.
Cristina-Paula Ursu, Luminița Elena Furcea, Bogdan Procopeț, Răzvan Alexandru Ciocan, Ștefan Ursu, Claudia Diana Gherman, Dan Vălean, Rodica Sorina Pop, Emil Ioan Moiș, Horia Ștefănescu, Carmen Socaciu, Nadim Al Hajjar, Florin Graur   +12 more
doaj   +1 more source

Mechanisms governing the fragmentation of glycerophospholipids containing choline and ethanolamine polar head groups

, 2017
Glycerophospholipids are the major amphiphilic molecules found in the plasma membrane bilayer of all vertebrate cells. Involved in many biological processes, their huge structural diversity and large concentration scale make their thorough ...
Jean-Claude Tabet, François Fenaille, Fenaille, François, Junot, Christophe, Benoit Colsch, Anna Warnet, Tabet, Jean-Claude, Warnet, Anna, Colsch, Benoît, Christophe Junot   +9 more
core   +1 more source

α-Lactalbumin binding and membrane integrity—effect of charge and degree of unsaturation of glycerophospholipids [PDF]

, 2005
Several studies have shown that the physical state of the phospholipid membrane has an important role in protein–membrane interactions, involving both electrostatic and hydrophobic forces.
Rødland, Ingunn, Martínez, Aurora, Øyvind Halskau, Ingunn Rødland, Aurora Martínez, Holm Holmsen, Halskau, Øyvind, Holmsen, Holm   +7 more
core   +1 more source

Image3_Plasmalogens, the Vinyl Ether-Linked Glycerophospholipids, Enhance Learning and Memory by Regulating Brain-Derived Neurotrophic Factor.TIF

, 2022
Plasmalogens (Pls), a kind of glycerophospholipids, have shown potent biological effects but their role in hippocampus-dependent memory remained mostly elusive.
Shiro Mawatari (12062999), Takehiko Fujino (12063002), Md. Shamim Hossain (12062996)   +2 more
core   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source

The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells

FEBS Open Bio
Glycerophospholipids, a primary component of cellular membranes, play important structural and functional roles in cells. In the remodelling pathway (Lands' cycle), the concerted actions of phospholipase As and lysophospholipid acyltransferases (LPLATs ...
Shirou Tabe, Hisako Hikiji, Tomomi Hashidate‐Yoshida, Hideo Shindou, Takao Shimizu, Kazuhiro Tominaga   +5 more
doaj   +1 more source

Stereochemical Analysis of Glycerophospholipids by Vibrational Circular Dichroism

, 2015
The stereochemistry of glycerophospholipids (GPLs) has been of interest for its roles in the evolution of life and in their biological activity. However, because of their structural complexity, no convenient method to determine their configuration has ...
Masataka Shibata (1522000), Daisuke Manai (1522003), Kenji Monde (1403233), Tohru Taniguchi (1403230), Yutaka Itabashi (1522006)   +4 more
core   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

The Role of Lipids in Parkinson’s Disease

Cells, 2019
Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and microgliosis.
Helena Xicoy, Bé Wieringa, Gerard J. M. Martens   +2 more
doaj   +1 more source